Tachykinin-mediated increase in motility acts independently of vasoactive intestinal polypeptide release in the canine ileum

Watson, Eleanor; Fox-Threlkeld, J. E. T.; Daniel, E. E.

doi:10.1139/y94-017

Cited by 7 publications

(1 citation statement)

References 21 publications

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“…(1994), although they could not determine the type of receptor present in the equine colon, they did establish that it was not the NK2 receptor which predominates in the equine small intestine. Because activation of NKl receptors results in contraction of the guinea pig colon (Zagorodnyuk et al 1993), and of the dog and rat ileum (Willis et al 1993;Watson et al 1994), it is likely that NKl receptors on equine colonic muscle also mediate the contraction caused by tachykinins in this tissue (Sellers et al 1985).…”

Section: Tachykinin Receptors In Smooth Musclementioning

confidence: 99%

Tachykinin receptors in the equine pelvic flexure

Sonea

Wilson

Bowker

et al. 1997

Equine Veterinary Journal

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Summary Tachykinins, of which substance P (SP) is the prototype, are neuropeptides which are widely distributed in the nervous systems. In the equine gut, SP is present in enteric nerves and is a powerful constrictor of enteric muscle; in other species, SP is also known to have potent vasodilatory and proinflammatory effects. The specific effects of SP are determined by the subtype of receptor present in the target tissue. There are 3 known subtypes of tachykinin receptors, distinguished by their relative affinities for SP and other tachykinins. The distribution of SP binding sites in the equine pelvic flexure was determined using 125I‐Bolton Hunter SP (I‐BHSP) autoradiography. Most I‐BHSP binding sites were determined to be saturable and specific, therefore presumably representing tachykinin receptors. The greatest degree of I‐BHSP binding occurred over very small vessels, and over the muscularis mucosae; I‐BHSP binding was also intense over the circular muscle of the muscularis externa and mucosa, and present, although less intense, over the longitudinal muscle of the muscularis externa. Competition of I‐BHSP with specific receptor agonists for binding sites in the equine pelvic flexure were used to determine the subtypes of tachykinin receptors present. The neurokinin‐1 receptor subtype predominated in the equine pelvic flexure, followed by the neurokinin‐3 receptor subtype.

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Section: Tachykinin Receptors In Smooth Musclementioning

confidence: 99%