Tachykinins and kinins in antigen-evoked plasma extravasation in guinea-pig nasal mucosa

Ricciardolo, Fabio Luigi Massimo; Nadel, Jay A.; Bertrand, Claude; Yamawaki, Isao; Chan, Brendan; Geppetti, Pierangelo

doi:10.1016/0014-2999(94)90310-7

Cited by 27 publications

(21 citation statements)

References 26 publications

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“…The respiratory nasal mucosa was taken according to the methods described previously (Petersson et al, 1993;Ricciardolo et al, 1994). The conjunctiva adherent to either the palpebra or the sclera was removed.…”

Section: Protocolsmentioning

confidence: 99%

“…15 min before the administration of the stimulus. The doses of bradykinin and substance P were selected in order to give submaximal effects (Ricciardolo et al, 1994;Figini et al, 1995 …”

Section: Protocolsmentioning

confidence: 99%

“…The plasma extravasation induced by local application of bradykinin to the guinea-pig conjunctiva (Figini et al, 1995) and nasal mucosa (Ricciardolo et al, 1994) is due largely to the stimulation of sensory nerves and the release of tachykinins. Since the bradykinin B2 receptor antagonist, HOE140, blocked the plasma leakage produced by bradykinin in the conjunctiva (Figini et al, 1995) and nasal mucosa (Ricciardolo et al, 1994) it has been proposed that bradykinin stimulates trigeminal sensory nerves of these tissues by acting on B2 receptors (Ricciardolo et al, 1994;Figini et al, 1995). The present findings, showing that the non-peptide bradykinin B2 receptor antagonist, WIN 64338, blocked the bradykinin-induced increases in plasma extravasation, support this hypothesis.…”

Section: Guinea-pig Conjunctiva and Nasal Mucosamentioning

confidence: 99%

“…(100 nmol kg-1) previously used to block the bradykinin-induced plasma extravasation in the conjunctiva and nasal mucosa (Ricciardolo et al, 1994;Figini et al, 1995) …”

Section: Guinea-pig Conjunctiva and Nasal Mucosamentioning

confidence: 99%

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Inhibition of bradykinin‐evoked trigeminal nerve stimulation by the non‐peptide bradykinin B₂ receptor antagonist WIN 64338 in vivo and in vitro

Hall

Figini

Butt

et al. 1995

British J Pharmacology

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1 This study investigated the effect of the recently described non-peptide bradykinin B2 receptor antagonist, WIN 64338 ([[4-[[2-[[bis(cyclohexylamino) Barabe, 1980;Hall, 1992) and, in general, the acute proinflammatory effects Author for correspondence. of kinins are mediated via stimulation of the B2 receptor type (Hall, 1992;Geppetti, 1993). Recently, Salvino and colleagues (Salvino et al., 1993;Sawutz et al., 1994) announced the development of the first relatively high affinity non-peptide bradykinin B2 receptor antagonist, WIN 64338, MethodsRabbit iris sphincter Male New Zealand albino rabbits (2.5-3.0 kg) were killed by an i.v. overdose of pentobarbitone sodium. The eyes were enucleated immediately after death and opened by a midline incision 2 -3 mm dorsal to the limbus, followed by excision of Bdft Joumal of Phanucology (IM) 116, 3164 -3-168

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Section: Protocolsmentioning

confidence: 99%

“…15 min before the administration of the stimulus. The doses of bradykinin and substance P were selected in order to give submaximal effects (Ricciardolo et al, 1994;Figini et al, 1995 …”

Section: Protocolsmentioning

confidence: 99%

Section: Guinea-pig Conjunctiva and Nasal Mucosamentioning

confidence: 99%

“…(100 nmol kg-1) previously used to block the bradykinin-induced plasma extravasation in the conjunctiva and nasal mucosa (Ricciardolo et al, 1994;Figini et al, 1995) …”

Section: Guinea-pig Conjunctiva and Nasal Mucosamentioning

confidence: 99%

See 2 more Smart Citations

Inhibition of bradykinin‐evoked trigeminal nerve stimulation by the non‐peptide bradykinin B₂ receptor antagonist WIN 64338 in vivo and in vitro

Hall

Figini

Butt

et al. 1995

British J Pharmacology

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“…However, in the majority of these papers, the results were either from the experiments by single challenge by the topical application of intranasal instillation with antigen solution (1,2) or from the method of antigen perfusion of the nasal cavity from the pharynx to the nostrils (3,4). To resolve such drawbacks in experimental allergic rhinitis, we attempted to establish a good experimental model for research on allergic rhinitis using the guinea pig.…”

mentioning

confidence: 99%

A New Model of Experimental Allergic Rhinitis Using Japanese Cedar Pollen in Guinea Pigs

Nabe

Shimizu

Mizutani

et al. 1997

Japanese Journal of Pharmacology

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ABSTRACT-In the majority of the models of experimental allergic rhinitis, antigen challenge has been performed by single topical instillation or perfusion with the solution. The present study was performed to establish a good model using Japanese cedar pollen, which is able to repeatedly induce allergy restricted to the upper airway. Guinea pigs sensitized with the pollen extracts were subjected to quantitative and repeated inhaling of the pollen with a devised apparatus. Following the respective challenges, the nasal cavity was washed with a new technique: Washing with physiologic saline was performed from one nostril to the other one, the latter of which was kept under slightly reduced pressure. When the animal was subjected to cedar pollen inhalation, almost all the pollens inhaled were located in the upper airway. At the 5th inhalation, nasal cavity lavage revealed that both albumin leakage and histamine release into the nasal cavity were in creased at maximum levels in 1 hr (respectively 2 mg and 3 ng/animal); and at the same time, a considerable number of leukocytes, especially eosinophils, were found migrating into the nasal cavity for at least 10 hr. The present methods can permit various analyses of allergic rhinitis and the assessment of drugs without sacrificing the animal over the long term.

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Neuropeptides

Schäffer¹,

Beiter²,

Becker³

et al. 1998

Arch Surg

160

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uccessful repair of injured tissues requires diverse interactions between cells, biochemical mediators, and the cellular microenvironment. [1][2][3] Much has been learned about the individual events that are involved in this process, but their integration is clearly far more complex than has been imagined, and the important role of neurogenic stimuli is only recently being recognized.Neurogenic stimuli profoundly affect cellular events that are involved in inflammation, proliferation, and matrix, as well as cytokine and growth factor synthesis. Immune cells regulated by neuropeptides include lymphocyte subsets, macrophages, and mast cells. In addition, neuropeptides may affect the proliferative and synthetic activity of epithelial, vascular, and connective tissue cells. Furthermore, a close interaction between the nervous and the immune systems has become obvious. 4 The peripheral nervous system (PNS), acting through neuropeptides, not only relays sensory information to the central nervous system (CNS) but also plays an effector role in the inflammatory, proliferative, and reparative processes after injury. These effects range from growth factor and cytokine responses to control of local blood flow. Neuropeptides mediate many of the actions important in tissue-nervous system communication.We review the accumulated knowledge about the role of neuropeptides in inflammation as it pertains to tissue repair. NEUROPEPTIDES OF THE PNSNeuropeptides constitute one of the largest families of extracellular messengers, having a long phylogenetic history. They can act as neurotransmitters, hormones, and paracrine factors.

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Tachykinins and kinins in antigen-evoked plasma extravasation in guinea-pig nasal mucosa

Cited by 27 publications

References 26 publications

Inhibition of bradykinin‐evoked trigeminal nerve stimulation by the non‐peptide bradykinin B₂ receptor antagonist WIN 64338 in vivo and in vitro

Inhibition of bradykinin‐evoked trigeminal nerve stimulation by the non‐peptide bradykinin B₂ receptor antagonist WIN 64338 in vivo and in vitro

A New Model of Experimental Allergic Rhinitis Using Japanese Cedar Pollen in Guinea Pigs

Neuropeptides

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Tachykinins and kinins in antigen-evoked plasma extravasation in guinea-pig nasal mucosa

Cited by 27 publications

References 26 publications

Inhibition of bradykinin‐evoked trigeminal nerve stimulation by the non‐peptide bradykinin B2 receptor antagonist WIN 64338 in vivo and in vitro

Inhibition of bradykinin‐evoked trigeminal nerve stimulation by the non‐peptide bradykinin B2 receptor antagonist WIN 64338 in vivo and in vitro

A New Model of Experimental Allergic Rhinitis Using Japanese Cedar Pollen in Guinea Pigs

Neuropeptides

Contact Info

Product

Resources

About

Inhibition of bradykinin‐evoked trigeminal nerve stimulation by the non‐peptide bradykinin B₂ receptor antagonist WIN 64338 in vivo and in vitro

Inhibition of bradykinin‐evoked trigeminal nerve stimulation by the non‐peptide bradykinin B₂ receptor antagonist WIN 64338 in vivo and in vitro