Tacrolimus for the Treatment of Subepithelial Infiltrates Resistant to Topical Steroids After Adenoviral Keratoconjunctivitis

Abstract

Topical 0.03% tacrolimus seemed to be an effective corticosteroid-sparing agent for the treatment of SEIs after AK.

Sterile Corneal Infiltrates Secondary to Psoriasis Exacerbations: Topical Tacrolimus as an Alternative Treatment Option

“…Thus, there are other available treatments such as immunosuppressors, which could represent an alternative to the conventional treatment applied. 12,13 Taking into account that psoriasis is a T-cell-mediated autoimmune inflammatory disorder, the elected immunosuppressive treatment should inhibit T-lymphocyte proliferation, such as tacrolimus. 7 This was the rationale in this report to apply 0.02% topical tacrolimus ointment to both patients achieving successful results.…”

Topical tacrolimus in anterior segment inflammatory disorders

“…Therefore, topical tacrolimus may be considered an effective treatment regimen. Topical tacrolimus 0.03% was found to be an effective corticosteroid-sparing agent for the treatment of patients with symptomatic corneal subepithelial infiltrates secondary to adenoviral keratoconjunctivitis [47, 48]. …”

Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis

“…Tacrolimus has a more potent immunosuppressant action, 15 and initial evidence indicates that it may be more effective for treating some ocular surface diseases with fewer side effects than cyclosporine A (burning sensation and pain on application). 16 Tacrolimus generally is an effective alternative for specific ocular inflammatory conditions refractory to traditional treatments such as dry eye, 17 ocular surface inflammation in patients with graft versus host disease, 18,19 allergic 10,16,[20][21][22][23][24][25][26][27][28][29] lens-induced papillary conjunctivitis, 30 corneal subepithelial infiltrates secondary to adenoviral keratoconjunctivitis, 31 superior limbic keratoconjunctivitis, 32 refractory phlyctenular keratoconjunctivitis, 33 ocular cicatricial pemphigoid, 34,35 and anterior segment inflammatory disorders. [5][6][7]9 In addition, patients who are intolerant of cyclosporine can be treated effectively with topical tacrolimus.…”