Tailor-made polysaccharides containing uniformly distributed repeating units based on the xanthan gum skeleton

Wu, Mengmeng; Qu, Jianmei; Tian, Xuefeng; Zhao, Xin; Shen, Yaqi; Su, Zhong; Chen, Peishan; Li, Guoqiang; Ma, Ting

doi:10.1016/j.ijbiomac.2019.03.130

Cited by 35 publications

(24 citation statements)

References 32 publications

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“…The time/ temperature superposition principle is applied over all the temperature range for shear and elongation measurements to compare the structural changes induced by the transition (33). The T m can be determined through in situ heating (25-80 °C) and cooling (80-25 °C) at a rate of 3 °C/min, as previously reported by Wu Ma et al The increase in temperature promotes a structural change in xanthan gum from a double helix to a single helix conformation, followed by a disordered coil structure (27,29). These conformational transitions depend on the ionic strength and pH, as well as the structural features, such as the pyruvic and acetic acid content.…”

Section: Xanthan Gum Chemistrymentioning

confidence: 95%

“…The Xanthan gum has a primary structure constituted by a cellulose-like backbone (3 → 1) linked to a side chain of α-D-mannose-(2 → 1)-β-D-glucuronic acid-(4 → 1)-β-D-mannose (Figure 1). In this regard, the constituent elements generally exist in a molar ratio of 2.8:2.0:2.0 for D-glucose, D-mannose, and D-glucuronic acid, respectively (26,27). Moreover, the xanthan gum can exist as a single, double, or triple helix (26).…”

Section: Xanthan Gum Chemistrymentioning

confidence: 99%

“…Xanthan gum is identified based on the formation of a firm rubbery gel when a hot aqueous solution of a mixture of xanthan gum and carob bean gum (0.5% w/v each) is cooled below 40°C. The molecular stiffness of xanthan gum induces an extended conformation of the molecules in solution, obtaining high viscosity solutions compared with other polysaccharide solutions (26,27,(29)(30)(31).…”

Section: Xanthan Gum Chemistrymentioning

confidence: 99%

“…In this regard, there are six units of the pyruvate and acetyl ones in natural xanthan. The pyruvate molecules could destabilize the helical conformation, whereas a high pyruvate presence increases the viscosity (27,29,32).…”

Section: Xanthan Gum Chemistrymentioning

confidence: 99%

“…On the other hand, in recent years, the attention in xanthan gum increased because some research groups reported an antioxidant activity against the effect of hydroxyl radical (·OH) on tissues (27). Similarly, Kang et al investigated the ·OH scavenging effects of xanthan gum products obtained from Xanthomonas campestris supplemented with furfural, the systems with the lowest level of furfural (1 g/L) exposed the maximum scavenging activity.…”

Section: Xanthan Gum Chemistrymentioning

confidence: 99%

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Xanthan gum in drug release

Cortés

Caballero-Florán

Mendoza‐Muñoz

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Controlled release is of vital relevance for many drugs; thus, there is a keen interest in materials that can improve the release profiles of formulations administered via buccal, transdermal, ophthalmic, vaginal, and nasal. The desirable effects of those materials include the improvement of stability, adhesiveness, solubility, and retention time. Hence, different synthetic and natural polymers are utilized to achieve these objectives. In this respect, xanthan gum is an anionic polysaccharide that can be obtained from Xanthomonas bacteria. It is a natural polymer broadly employed in numerous food products, lotions, shampoos, and dermatological articles. Furthermore, due to its physicochemical features, xanthan gum is growingly utilized for the development and improvement of drug delivery systems. In this regard, encouraging findings have been revealed by recent formulations for pharmaceutical applications, including antiviral carriers, antibacterial transporters, transdermal patches, vaginal formulations, and anticancer medications. In this article, we perform a concise description of the chemical properties of xanthan gum and its role as a modifier of drug release. Furthermore, we present an outlook of the state of the art of research focused on the utilization of xanthan gum in varied pharmaceutical formulations, which include tablets, films, hydrogels, and nanoformulations. Finally, we discuss some perspectives about the use of xanthan gum in these formulations.

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Section: Xanthan Gum Chemistrymentioning

confidence: 95%

Section: Xanthan Gum Chemistrymentioning

confidence: 99%

Section: Xanthan Gum Chemistrymentioning

confidence: 99%

Section: Xanthan Gum Chemistrymentioning

confidence: 99%

Section: Xanthan Gum Chemistrymentioning

confidence: 99%

See 3 more Smart Citations

Xanthan gum in drug release

Cortés

Caballero-Florán

Mendoza‐Muñoz

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Drug Delivery Systems Based on Xanthan

Atanase,

Popa

2024

Biopolymers in Pharmaceutical and Food Applications

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Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications

Hajebi

Yousefiasl

Rahimmanesh

et al. 2022

Adv Healthcare Materials

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Conventional drug delivery systems are challenged by concerns related to systemic toxicity, repetitive doses, drug concentrations fluctuation, and adverse effects. Various drug delivery systems are developed to overcome these limitations. Nanomaterials are employed in a variety of biomedical applications such as therapeutics delivery, cancer therapy, and tissue engineering. Physiochemical nanoparticle assembly techniques involve the application of solvents and potentially harmful chemicals, commonly at high temperatures. Genetically engineered organisms have the potential to be used as promising candidates for greener, efficient, and more adaptable platforms for the synthesis and assembly of nanomaterials. Genetically engineered carriers are precisely designed and constructed in shape and size, enabling precise control over drug attachment sites. The high accuracy of these novel advanced materials, biocompatibility, and stimuli‐responsiveness, elucidate their emerging application in controlled drug delivery. The current article represents the research progress in developing various genetically engineered carriers. Organic‐based nanoparticles including cellulose, collagen, silk‐like polymers, elastin‐like protein, silk‐elastin‐like protein, and inorganic‐based nanoparticles are discussed in detail. Afterward, viral‐based carriers are classified, and their potential for targeted therapeutics delivery is highlighted. Finally, the challenges and prospects of these delivery systems are concluded.

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Tailor-made polysaccharides containing uniformly distributed repeating units based on the xanthan gum skeleton

Cited by 35 publications

References 32 publications

Xanthan gum in drug release

Xanthan gum in drug release

Drug Delivery Systems Based on Xanthan

Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications

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