Tailored-CuO-nanowire decorated with folic acid mediated coupling of the mitochondrial-ROS generation and miR425-PTEN axis in furnishing potent anti-cancer activity in human triple negative breast carcinoma cells

Ahir, Manisha; Bhattacharya, Saurav; Karmakar, Soumendu; Mukhopadhyay, Ayan; Mukherjee, Sudeshna; Ghosh, Swatilekha; Chattopadhyay, Sreya; Patra, Prasun; Adhikary, Arghya

doi:10.1016/j.biomaterials.2015.10.044

Cited by 82 publications

(47 citation statements)

References 51 publications

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“…Peaks at 1102 cm −1 may be attributed to FeOOH and 1400 cm −1 due to C−H symmetric stretching vibration . FA shows a specific peak nearly at 1696 cm −1 , which slightly shifted to 1604 cm −1 in Figure (b) confirming the conjugation of FA with the CFMNPs …”

Section: Resultssupporting

confidence: 58%

“…FA was attached to the CFMNPs by following an article . Briefly, 12.5 mg FA was dispersed in 12.5 mL dimethyl sulfoxide (DMSO).…”

Section: Methodsmentioning

confidence: 99%

“…This characteristic can be utilized for delivering drugs under low magnetic field also. [37] 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 3.3 TG-DTA Measurement Figure 3 represents the thermal behavior of the samples using TG-DTA. The measurement has been done by the temperature ranges from 27 and 525 8C, so that we can understand the thermal stability of the sample.…”

Section: Magnetic Measurements and Relaxation Studymentioning

confidence: 99%

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Improvement of Anticancer Drug Release by Cobalt Ferrite Magnetic Nanoparticles through Combined pH and Temperature Responsive Technique

et al. 2018

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This work reports the application possibilities of cobalt ferrite (CoFe O ) magnetic nanoparticles (CFMNPs) for stimuli responsive drug delivery by magnetic field induced hyperthermia technique. The CFMNPs were characterized by X-ray diffraction (XRD) with Rietveld analysis, field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), selected area electron diffraction (SAED), fourier transform infrared spectroscopy (FTIR), thermogravimetry and differential thermal analysis (TG-DTA), vibrating sample magnetometer (VSM) and superconducting quantum interference device (SQUID) magnetometry. Particles were functionalized with folic acid (FA) by EDC-NHS coupling method and loaded with anticancer drug (DOX) by activated folate ions. The drug release was studied as a function of time at two different temperatures (37 and 44 °C) under pH∼5.5 and 7. It was observed that the drug release rate is higher at elevated temperature (44 °C) and acidic pH∼5.5 as compared to our normal body temperature and pH∼7 using the CFMNPs. This way, we have developed a pH and temperature sensitive drug delivery system, which can release the anticancer drug selectively by applying ac magnetic field as under ac field particles are heated up. We have calculated the amount of heat generation by the particles around 1.67 °C per second at ∼600 Hz frequency. By MTT assay on cancer cell and normal cell, it was confirmed that CFMNPs are nontoxic and biocompatible in nature, which assures that our synthesized particles can be successfully used in localized cancer treatment by stimuli responsive drug delivery technique.

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Section: Resultssupporting

confidence: 58%

“…FA was attached to the CFMNPs by following an article . Briefly, 12.5 mg FA was dispersed in 12.5 mL dimethyl sulfoxide (DMSO).…”

Section: Methodsmentioning

confidence: 99%

Section: Magnetic Measurements and Relaxation Studymentioning

confidence: 99%

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Improvement of Anticancer Drug Release by Cobalt Ferrite Magnetic Nanoparticles through Combined pH and Temperature Responsive Technique

et al. 2018

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“…In another study, Ahir et al investigated the cytotoxicity of CuO NPs in HEP G2 cells and their results showed that these particles inhibit the growth of melanoma cells. CuO NPs fabricated with folic acid proved to be an efficient therapeutic option against triple negative breast cancer cells [70]. …”

Section: Medical Applicationsmentioning

confidence: 99%

Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles

et al. 2016

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This study aims to provide an updated survey of the main synthesis methods of copper oxide (CuO) nanoparticles in order to obtain tailored nanosystems for various biomedical applications. The synthesis approach significantly impacts the properties of such nanoparticles and these properties in turn have a significant impact on their biomedical applications. Although not widely investigated as an efficient drug delivery system, CuO nanoparticles have great biological properties including effective antimicrobial action against a wide range of pathogens and also drug resistant bacteria. These properties have led to the development of various approaches with direct applications to the biomedical field, such as tailored surfaces with antimicrobial effect, wound dressings and modified textiles. It is also believed that these nanosystems could represent efficient alternatives in the development of smart systems utilized both for the detection of pathogens and for the treatment of infections.

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“…The Optical imaging (OI) technology (sometimes referred to as biophotonics), the inclusive term often used for different types of infrared, ultraviolet, and visible light, as well as sometimes also photoacoustic (see above) applications in biomedical imaging, have a number of interesting publications regarding NP applications for both PCa and BC [319,392,393,394,395,396,397,398,399,400]. Generally, a NP-based OI approach could enable or optimize an optical excitation energy in, for example, tumor tissue, enable multispectral imaging by combining spectroscopy and OI, or make possible multiplex imaging by using different color emitters for different targets simultaneously [300].…”

Section: Multimodal Imaging Options For Prostate and Breast Cancermentioning

confidence: 99%

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Elgqvist

2017

IJMS

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Prostate and breast cancer are the second most and most commonly diagnosed cancer in men and women worldwide, respectively. The American Cancer Society estimates that during 2016 in the USA around 430,000 individuals were diagnosed with one of these two types of cancers, and approximately 15% of them will die from the disease. In Europe, the rate of incidences and deaths are similar to those in the USA. Several different more or less successful diagnostic and therapeutic approaches have been developed and evaluated in order to tackle this issue and thereby decrease the death rates. By using nanoparticles as vehicles carrying both diagnostic and therapeutic molecular entities, individualized targeted theranostic nanomedicine has emerged as a promising option to increase the sensitivity and the specificity during diagnosis, as well as the likelihood of survival or prolonged survival after therapy. This article presents and discusses important and promising different kinds of nanoparticles, as well as imaging and therapy options, suitable for theranostic applications. The presentation of different nanoparticles and theranostic applications is quite general, but there is a special focus on prostate cancer. Some references and aspects regarding breast cancer are however also presented and discussed. Finally, the prostate cancer case is presented in more detail regarding diagnosis, staging, recurrence, metastases, and treatment options available today, followed by possible ways to move forward applying theranostics for both prostate and breast cancer based on promising experiments performed until today.

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Tailored-CuO-nanowire decorated with folic acid mediated coupling of the mitochondrial-ROS generation and miR425-PTEN axis in furnishing potent anti-cancer activity in human triple negative breast carcinoma cells

Cited by 82 publications

References 51 publications

Improvement of Anticancer Drug Release by Cobalt Ferrite Magnetic Nanoparticles through Combined pH and Temperature Responsive Technique

Improvement of Anticancer Drug Release by Cobalt Ferrite Magnetic Nanoparticles through Combined pH and Temperature Responsive Technique

Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

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