Tailored wastewater surveillance framework uncovered the epidemics of key pathogens in a Northwestern city of China

Li, Haifeng; He, Fenglan; Lv, Ziquan; Yi, Liu; Zhang, Ziqiang; Li, Hui; Fu, Songzhe

doi:10.1016/j.scitotenv.2024.171833

Science of The Total Environment

2024

DOI: 10.1016/j.scitotenv.2024.171833

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Tailored wastewater surveillance framework uncovered the epidemics of key pathogens in a Northwestern city of China

Haifeng Li,

Fenglan He,

Ziquan Lv

et al.

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2024

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Cited by 2 publications

References 54 publications

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Wastewater Surveillance Uncovered the Impacts of the Timing of COVID-19 on the Epidemic Trajectories of Other Respiratory Diseases in Two Northeastern Cities in China

Li,

Zhang,

Liu

et al. 2024

ACS EST Water

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In this study, we conducted quantitative polymerase chain reaction (qPCR)-based wastewater surveillance for 12 prominent respiratory pathogens in two northeastern cities of China, Dalian, and Benxi, to understand the cocirculation patterns between COVID-19 and other respiratory diseases from October 2022 to July 2023. Wastewater surveillance revealed that Influenza A virus (IAV) and respiratory syncytial virus (RSV) sewage concentrations exhibited an upward trend from October 2022 in both cities but with distinct epidemic trajectories. In Dalian, IAV and RSV sewage concentrations both peaked in early December, followed by a rapid decline since the emergence of COVID-19 on November 23, 2022. In Benxi, two bell-shaped curves were observed for IAV and RSV sewage concentrations, both peaking in mid-December of 2022, even though severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in wastewater on December 8, 2022. After a rapid decline in SARS-CoV-2 sewage concentrations in January 2023, a new wave of IAV in wastewater occurred between February and early April in both cities, followed by a surge of SARS-CoV-2 RNA in early May. Meanwhile, an out-of-season epidemic of RSV from March to May was observed in Benxi based on the cities’ sewage concentrations. This study highlights the impact of the timing of COVID-19 on the epidemic trajectories of other respiratory diseases.

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Wastewater Surveillance Uncovered the Impacts of the Timing of COVID-19 on the Epidemic Trajectories of Other Respiratory Diseases in Two Northeastern Cities in China

Li,

Zhang,

Liu

et al. 2024

ACS EST Water

View full text Add to dashboard Cite

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Surveillance of Emerging Rodent-Borne Pathogens in Wastewater in Taiwan: A One Health Approach

Tsai,

Yen,

Tung

et al. 2024

TropicalMed

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Leptospirosis and hantavirus syndrome are two major rodent-borne diseases in Taiwan. Rocahepevirus ratii (RHEV), a virus closely related to hepatitis E virus (HEV, Paslahepevirus balayani), is emerging and has been reported to cause hepatitis in humans. We employed wastewater-based epidemiology to actively monitor rodent-borne pathogens, and the correlations with human cases were evaluated. Wastewater was collected using grab sampling at 11 sites along a sewer system including influents and effluents at a wastewater treatment plant in Tamsui, New Taipei City, Taiwan, monthly during June 2023 to May 2024. The presence of pathogens was examined by reverse transcription-polymerase chain reaction (RT-PCR). The result showed an overall positivity rate of 38.2% (50/131). Leptospira was detected most often (48/131, 36.6%), and RHEV and hantaviruses were found once each during the study period. Sequencing identified Leptospira interrogans close to isolates from rodents and human cases, while sequences of hantavirus and RHEV were most similar to isolates from rodents. No significant correlation was found with human cases or positive samples for rodent DNA. Here, we present an example of a One Health approach applying wastewater to environmental surveillance for the early detection and prevention of emerging diseases.

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Tailored wastewater surveillance framework uncovered the epidemics of key pathogens in a Northwestern city of China

Cited by 2 publications

References 54 publications

Wastewater Surveillance Uncovered the Impacts of the Timing of COVID-19 on the Epidemic Trajectories of Other Respiratory Diseases in Two Northeastern Cities in China

Wastewater Surveillance Uncovered the Impacts of the Timing of COVID-19 on the Epidemic Trajectories of Other Respiratory Diseases in Two Northeastern Cities in China

Surveillance of Emerging Rodent-Borne Pathogens in Wastewater in Taiwan: A One Health Approach

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