Tailoring the mechanoresponsive release from silica nanocapsules

Uebel, Fabian; Thérien-Aubin, Héloı̈se; Landfester, Katharina

doi:10.1039/d1nr04697g

Cited by 6 publications

(6 citation statements)

References 43 publications

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“…Nanocapsules − are hollow nanoparticles, 10–200 nm in diameter, that encapsulate liquids or gases inside a thin shell. Inorganic, biological, and polymeric nanocapsules have been engineered to release their contents with high spatiotemporal control. , The ability to isolate and subsequently release chemicals and materials with nanoscale precision has broad application ,, in drug delivery, , food sciences, cosmetics, self-healing materials, , pressure sensors, mechanical actuators, battery electrodes, − and carbon capture. , In these applications, cargo release can be stimulated via shifts in pH or osmotic pressure, or by exposure to chemicals, heat, − light, − magnetic fields, shear flow, ultrasound, or mechanical force. , Such triggering relies on the fact that the thin walls of the nanocapsules make them susceptible to buckling and collapse under compressive strain. This buckling is driven by the conversion of the in-plane energy required to stretch or compress the shell membrane into energy used to bend the membrane out-of-plane. , As a result, a small amount of in-plane shell compression can lead to large and abrupt distortions of the nanocapsule morphology.…”

Section: Introductionmentioning

confidence: 99%

“…Buckling was initiated by irradiating the nanocapsules with an electron dose rate much higher than necessary for imaging. Unlike mechanically driven deformations, ,,, the electron beam is a contactless trigger that can degrade the polymer walls of the nanocapsule and is analogous to other remote triggers like heat , or light . Using this in situ TEM approach, we recorded different buckling morphologies of nanocapsules and compared them to ex situ experiments, microscale capsules, and Monte Carlo (MC) simulations.…”

Section: Introductionmentioning

confidence: 99%

“…17,18 In these applications, cargo release can be stimulated via shifts in pH 19 or osmotic pressure, 12 or by exposure to chemicals, 20 heat, [21][22][23] light, [22][23][24] magnetic fields, 25 shear flow, 26 ultrasound 27 or mechanical force. 11,28 Such triggering relies on the fact that the thin walls of the nanocapsules make them susceptible to buckling and collapse under compressive strain. This buckling is driven by the conversion of the in-plane energy required to stretch or compress the shell membrane into energy used to bend the membrane out-of-plane.…”

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confidence: 99%

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Dynamics of Polymer Nanocapsule Buckling and Collapse Revealed by In Situ Liquid-Phase TEM

et al. 2022

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Nanocapsules are hollow nanoscale shells that have applications in drug delivery, batteries, selfhealing materials, and as model systems for naturally occurring shell geometries. While many nanocapsule applications require release of their cargo accompanied by their buckling and collapse, the details of this transient buckling process have not been directly observed. Here we use in situ liquid phase transmission electron microscopy to record the electron-irradiationinduced buckling in spherical 60-187 nm polymer capsules with 3.5 nm walls. We observe in real-time the release of aqueous cargo from these nanocapsules and their buckling into morphologies with single or multiple indentations. The in situ buckling of nanoscale capsules is compared to ex situ measurements of collapsed and micrometer-sized capsules and to Monte Carlo (MC) simulations. The shape and dynamics of the collapsing nanocapsules are consistent with MC simulations which reveal that the excessive wrinkling of nanocapsule with ultrathin walls results from their large Föppl-von Kármán numbers around 10 5 . Our experiments suggest design rules for nanocapsules with desired buckling response based on parameters such as capsule radius, wall thickness and collapse rate.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Dynamics of Polymer Nanocapsule Buckling and Collapse Revealed by In Situ Liquid-Phase TEM

et al. 2022

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“…The result is a high-resolution 3D profile of the surface under study. The principal advantage of AFM over electron microscopy is that it permits the imaging of almost any type of surface and biomolecules under different physicochemical conditions, during biological processes, or even the study of the mechanical properties of delivery systems at the nanoscale [45,48].…”

Section: Morphologymentioning

confidence: 99%

Lipid and Polymeric Nanocapsules

Rochín-Wong¹,

Rivas²

2022

Drug Carriers

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In recent years, innovative drug nanocarriers have been developed to enhance stability, bioavailability, and provide sustained release. In this chapter, systems based on natural macromolecules, lipids, or polymeric/polyelectrolyte nanocapsules and their principal chemical and functional characteristics are described. Nano-vesicular systems are especially relevant in different fields. Particularly, a promising potential is offered by systems based on colloidal nanocapsules, that exhibit a typical core-shell structure in which the drug can be confined into the cavity or in the polymeric coating that surrounds it. Both the cavity and the active substance can be lipophilic or hydrophilic and in solid or liquid form depending on the materials and methods used, making these nanocapsules attractive carriers for drug delivery. In addition, a compilation of different methods and materials employed in the preparation of these nanosystems and a recent review of applications of lipid and polymeric nanocapsules have been made, focussing on the encapsulation of drugs.

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“…However, a study of the mechanical properties of individual submicron silica particles and capsules is still challenging due to a combination of their small size and the high stiffness of silica. There are only very few studies available focused on experimental measurements of the mechanical properties of silica hollow [ 45 , 46 , 47 ] and solid [ 48 , 49 , 50 ] particles.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Elasticity Mapping of Submicron Silica Hollow Particles by PeakForce QNM AFM Mode

et al. 2023

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Silica hollow spheres with a diameter of 100–300 nm and a shell thickness of 8±2 nm were synthesized using a self-templating amphiphilic polymeric precursor, i.e., poly(ethylene glycol)-substituted hyperbranched polyethoxysiloxane. Their elastic properties were addressed with a high-frequency AFM indentation method based on the PeakForce QNM (quantitative nanomechanical mapping) mode enabling simultaneous visualization of the surface morphology and high-resolution mapping of the mechanical properties. The factors affecting the accuracy of the mechanical measurements such as a local slope of the particle surface, deformation of the silica hollow particles by a solid substrate, shell thickness variation, and applied force range were analysed. The Young’s modulus of the shell material was evaluated as E=26±7 GPa independent of the applied force in the elastic regime of deformations. Beyond the elastic regime, the buckling instability was observed revealing a non-linear force–deformation response with a hysteresis between the loading and unloading force–distance curves and irreversible deformation of the shell at high applied forces. Thus, it was demonstrated that PeakForce QNM mode can be used for quantitative measurements of the elastic properties of submicon-sized silica hollow particles with nano-size shell thickness, as well as for estimation of the buckling behaviour beyond the elastic regime of shell deformations.

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Tailoring the mechanoresponsive release from silica nanocapsules

Abstract: Triggering the release of encapsulated cargos using mechanical stress acting on a nanocarrier is a strategy with potential application from drug delivery to self-healing coatings. The mechanically triggered release of...

Cited by 6 publications

References 43 publications

Dynamics of Polymer Nanocapsule Buckling and Collapse Revealed by In Situ Liquid-Phase TEM

Dynamics of Polymer Nanocapsule Buckling and Collapse Revealed by In Situ Liquid-Phase TEM

Lipid and Polymeric Nanocapsules

Quantitative Elasticity Mapping of Submicron Silica Hollow Particles by PeakForce QNM AFM Mode

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