Tailoring zein nanoparticle functionality using biopolymer coatings: Impact on curcumin bioaccessibility and antioxidant capacity under simulated gastrointestinal conditions

Yao, Kangfei; Chen, Weijun; Song, Fenglin; McClements, David Julian; Hu, Kun

doi:10.1016/j.foodhyd.2017.12.029

Cited by 119 publications

(54 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Figure 1, the ζ-potential reversal of zein particles after mixing with caseinate-pectin complexes from positive to negative, indicated the successful adsorption of caseinate-pectin complexes onto zein particle surfaces. Compared to that of caseinate-pectin complexes at the same pectin to caseinate mass ratio, a less absolute negative ζ-potential value was observed for zein-caseinate-pectin particles, which might be attributed to possible charge neutralization by the cationic groups in zein molecules [13]. Moreover, it was observed that a limiting ζ-potential value (−20.5 mV) of zein-caseinate-pectin particles was also reached at pectin to caseinate mass ratio of 1 and further increasing its mass ratio to 2 did not significantly change the ζ-potential value (−20.4 mV).…”

Section: Resultsmentioning

confidence: 99%

“…Recently, the protein and polysaccharide complexes have been used as the coating layer for zein particles and the formed particles have shown an improved physical stability in acidic aqueous environment by having a thicker coating layer and stronger steric repulsion [13]. Some previous studies have shown that the coating of caseinate-pectin complex particles could enhance the stability of zein particles under simulated gastrointestinal conditions and meanwhile improve their encapsulation capacity [14,15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fabrication and Characterization of Zein Composite Particles Coated by Caseinate-Pectin Electrostatic Complexes with Improved Structural Stability in Acidic Aqueous Environments

Zhang

Wang

et al. 2019

Molecules

View full text Add to dashboard Cite

Zein composite particles coated with caseinate-pectin electrostatic complexes (zein-caseinate-pectin particles) were fabricated using an electrostatic deposition and liquid-liquid dispersion method without heating treatment. Compared to zein particles coated only with caseinate, the acidic stability of zein-caseinate-pectin particles was greatly improved, and the particle aggregation was suppressed at pH 3–6, especially at pH values near the isoelectric point of caseinate (pH 4–5). Besides, desirable long-term storage stability and re-dispersibility were observed. Under different zein to curcumin (Cur) feeding ratios (10:1, 20:1, 30:1 and 40:1, w/w), the Cur-loaded zein-caseinate-pectin particles had a spherical shape with an average diameter ranging from 358.37 to 369.20 nm, a narrow size distribution (polydispersity index < 0.2) and a negative surface charge ranging from −18.87 to −19.53 mV. The relatively high encapsulation efficiencies of Cur (81.27% to 94.00%) and desirable re-dispersibility were also achieved. Fluorescence spectroscopy indicated that the encapsulated Cur interacted with carrier materials mainly through hydrophobic interactions. The in-vitro release profile showed a sustained release of Cur from zein-caseinate-pectin particles in acidic aqueous environment (pH 4) up to 24 h, without any burst effect. In addition, the encapsulation retained more ABTS•+ radical scavenging capacity of Cur during 4 weeks of storage. These results suggest that zein-caseinate-pectin particles may be used as a potential delivery system for lipophilic nutrients in acidic beverages.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Zein Composite Particles Coated by Caseinate-Pectin Electrostatic Complexes with Improved Structural Stability in Acidic Aqueous Environments

Zhang

Wang

et al. 2019

Molecules

View full text Add to dashboard Cite

show abstract

“…To preserve the biological activity of quercetin, the use of hydrophobic matrices in the form of nanoparticles has been suggested (Mirpoor, Hosseini, & Nekoei, 2017;Ni, Hu, Sun, Zhao, & Xia, 2017). At this regard, protein matrices, such as kafirin and zein, play an important role in the construction of nanoparticles to entrap hydrophobic compounds (Tapia-Hernández et al, 2019a;Xiao, Nian, & Huang, 2015;Yao, Chen, Song, McClements, & Hu, 2017). The difference between zein and kafirin is that the native zein structure has fewer disulfide bonds and a higher proportion of α-helix in its secondary structure (Taylor, Anyango, Muhiwa, Oguntoyinbo, & Taylor, 2018).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Rodríguez-Félix

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

View full text Add to dashboard Cite

Quercetin is a hydrophobic flavonoid with high antioxidant activity. However, for biological applications, the bioavailability of quercetin is low due to physiological barriers. For this reason, an alternative is the protection of quercetin in matrices of biopolymers as zein. The objective of this work was to prepare and characterize quercetin‐loaded zein nanoparticles by electrospraying and its study of in vitro bioavailability. The physicochemical parameters such as viscosity, density, and electrical conductivity of zein solutions showed a dependence of the ethanol concentration. In addition, rheological parameters demonstrated that solutions of zein in aqueous ethanol present Newtonian behavior, rebounding in the formation of nanoparticles by electrospraying, providing spherical, homogeneous, and compact morphologies, mainly at a concentration of 80% (v/v) of ethanol and of 5% (w/v) of zein. The size and shape of quercetin‐loaded zein nanoparticles were studied by transmission electron microscopy (TEM), observing that it was entrapped, distributed throughout the nanoparticle of zein. Analysis by Fourier transform‐infrared (FT‐IR) of zein nanoparticles loaded with quercetin revealed interactions via hydrogen bonds. The efficacy of zein nanoparticles to entrap quercetin was particularly high for all quercetin concentration evaluated in this work (87.9 ± 1.5% to 93.0 ± 2.6%). The in vitro gastrointestinal release of trapped quercetin after 240 min was 79.1%, while that for free quercetin was 99.2%. The in vitro bioavailability was higher for trapped quercetin (5.9%) compared to free quercetin (1.9%), than of gastrointestinal digestion. It is concluded, that the electrospraying technique made possible the obtention of quercitin‐loaded zein nanoparticles increasing their bioavailability. Practical Application This type of nanosystems can be used in the food and pharmaceutical industry. Quercetin‐loaded zein nanoparticles for its improvement compared to free quercetin can be used to decrease the prevalence of chronic degenerative diseases by increasing of the bioavailability of quercetin in the bloodstream. Other application can be as an antioxidant system in functional foods or oils to increase shelf life.

show abstract

“…Nanoparticles with poly-ε-caprolactone (PCL) polymer would be a way to potentiate the action of curcumin, because it would be able to prolong the therapeutic efficacy and time of circulation (Dash & Konkimalla, 2012;Manjili et al, 2017). On the contrary, Eudragit ® polymer could release the active ingredient slowly and at specific pH (Beloqui et al, 2014), increasing local availability in the face of oxidative stress and intestinal absorption (Catalan-Latorre et al, 2016;Yao, Chen, Song, McClements, & Hu, 2017).…”

Section: Introductionmentioning

confidence: 99%

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

et al. 2019

View full text Add to dashboard Cite

The main objective of this study was to evaluate whether the addition of curcumin‐loaded nanocapsules (prepared and characterized) in the diets of dairy sheep improved milk quality. The nanocapsules were prepared using two polymers: poly‐ε‐caprolactone (PCL) and Eudragit L‐100. The nanocapsules contained 0.25 mg/ml (Nano‐Eudragit L‐100) and 2 mg/ml (Nano‐PCL) of curcumin. Dairy sheep were divided into four groups: A (control), B (30 mg free curcumin/kg concentrate), C (3 mg Nano‐PCL/kg concentrate), and D (3 mg Nano‐Eudragit/kg concentrate). We observed that the number of total leukocytes and serum globulin levels were lower in Group D than in the control (Group A) (p < 0.05). Antioxidant capacity against peroxyl radicals (ACAP) and catalase enzymes was elevated in Group D, with consequently reduced lipid peroxidation (LPO; p < 0.05). In milk, there were no differences in production and composition between groups during the experimental period (p > 0.05); however, ACAP increased and LPO decreased in milk. Practical applications Curcumin is a functional molecule with potent antioxidant, anti‐inflammatory, and antimicrobial actions, used frequently and with medical indications in human food. Free curcumin in sheep diets improves milk quality and increases its shelf life. This study showed that curcumin nanocapsules produced from the Eudragit L‐100 polymer potentiated the anti‐inflammatory and antioxidant actions of dairy sheep when used in the diet daily, at doses 10 times lower than that of free curcumin. These positive effects were reflected in higher total antioxidant capacity and lower lipid peroxidation in milk in sheep‐fed curcumin‐loaded Eudragit L‐100 nanocapsules, generating desirable milk properties. In practice, the use of nanotechnology enhances the beneficial effects of curcumin in milk, possibly creating a nutraceutical food desirable to consumers.

show abstract

Tailoring zein nanoparticle functionality using biopolymer coatings: Impact on curcumin bioaccessibility and antioxidant capacity under simulated gastrointestinal conditions

Cited by 119 publications

References 44 publications

Fabrication and Characterization of Zein Composite Particles Coated by Caseinate-Pectin Electrostatic Complexes with Improved Structural Stability in Acidic Aqueous Environments

Fabrication and Characterization of Zein Composite Particles Coated by Caseinate-Pectin Electrostatic Complexes with Improved Structural Stability in Acidic Aqueous Environments

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

Contact Info

Product

Resources

About