Takayasu’s arteritis progression on anti-TNF biologics: a case series

Osman, Mohammed; Aaron, Stephen; Noga, Michelle; Yacyshyn, Elaine

doi:10.1007/s10067-010-1658-1

Cited by 41 publications

(19 citation statements)

References 16 publications

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“…6 Preliminary studies have reported the efficacy of biological-targeting treatments such as TNF-α antagonists (infliximab, adalimumab, etanercept) and anti-IL-6 receptor (tocilizumab) in TA refractory to other immunosuppressive therapies. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Here, we report the long-term outcome of 49 TA patients treated with TNF-α antagonists and tocilizumab in this French nationwide study, and we compare their safety, their efficacy, and the factors predictive of treatment response.…”

Section: Editorial See P 1685 Clinical Perspective On P 1700mentioning

confidence: 99%

Efficacy of Biological-Targeted Treatments in Takayasu Arteritis

et al. 2015

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Section: Editorial See P 1685 Clinical Perspective On P 1700mentioning

confidence: 99%

Efficacy of Biological-Targeted Treatments in Takayasu Arteritis

et al. 2015

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“…Los corticoides han demostrado disminuir hasta en 50% la progresión de las lesiones y la terapia inmunosupresora evita la re-estenosis (14) . Al ser irreversible la estenosis, la angioplastia precoz es necesaria para el manejo de la hipertensión renovascular y prevención de complicaciones (15) .…”

Section: Discussionunclassified

Presentación de un caso de arteritis de Takayasu en un adolescente

Aranda-Paniora¹,

Montoya²,

Vilca³

2016

An Fac med

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ResumenLa arteritis de Takayasu es una entidad rara en pediatría y su presentación clínica plantea diversos diagnósticos diferenciales. Se publica el caso de un adolescente de 14 años que ingresó a un Hospital de Lima con convulsiones tónico clónicas generalizadas e hipertensión arterial de grado 2. Posteriormente fue derivado para estudio al Instituto de Salud del Niño de Lima, Perú. Se revisa los criterios diagnósticos, su evolución y tratamiento. Palabras clave. Arteritis de Takayasu; Hipertensión Arterial; Pediatría. Abstract Takayasu arteritis is a rare entity in pediatrics and clinical presentation raises several differential diagnoses. We report the case of a 14-year-old boy with generalized tonic clonic seizures and stage 2 hypertension referred for study to the Instituto Nacional de Salud del Niño in Lima, Peru. Diagnostic criteria, evolution and treatment are reviewed. Keywords. Takayasu's Arteritis; Hypertension; Pediatrics. An Fac med. 2016;77(2):167-70 / http://dx

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“…The clinical prognosis of the disease is variable; use of corticosteroid decreases progression of the lesion by 50%. Immunosupressive treatment provides better disease control and prevents recurrence of stenosis (13). Angioplasty is efficient in treatment of TA and increases 5-year survivial up to 80-95%.…”

Section: Takayasu Arteritismentioning

confidence: 99%

Diagnostic approach and current treatment options in childhood vasculitis

et al. 2015

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All inflammatory changes in the vessel wall are defined as vasculitis. Pediatric vasculitis may present with different clinical findings. Although Henoch-Schön-lein purpura which is the most common pediatric vasculitis generally recovers spontaneously, it should be monitorized closely because of the risk of renal failure. Although Kawasaki disease is easy to diagnose with its classical findings, the diagnosis may be delayed in case of incomplete Kawasaki disease. Kawasaki disease should be considered especially in infants in case of prolonged fever even if the criteria are not fully met and intravenous immunoglobulin treatment should be administered without delay in order to prevent development of coronary artery aneurism. Reaction at the site of administration of Bacillus Calmette-Guerin (BCG) vaccine may be observed as commonly as cervical lymphadenopathy in Kawasaki disease and may be used as a valuable finding in suspicious cases. Although anti-neutrophil cytoplasmic antibody-associated vasculitides are rare in children, renal involvement is more common and progression is more severe compared to adults. Hence, efficient and aggressive treatment is required. Takayasu's arteritis is observed commonly in young adult women and rarely in adolescent girls. Therefore, a careful physical examination and blood pressure measurement should be performed in addition to a detailed history in daily practice. In children with unexplained neurological findings, cerebral vasculitis should be considered in the absence of other systemic vasculitides and necessary radiological investigations should be performed in this regard. This review will provide an insight into the understanding of pediatric vasculitis, current diagnostic approaches and prognosis by the aid of new studies. (Turk Pediatri Ars 2015; 50: 194-205)

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Takayasu’s arteritis progression on anti-TNF biologics: a case series

Cited by 41 publications

References 16 publications

Efficacy of Biological-Targeted Treatments in Takayasu Arteritis

Efficacy of Biological-Targeted Treatments in Takayasu Arteritis

Presentación de un caso de arteritis de Takayasu en un adolescente

Diagnostic approach and current treatment options in childhood vasculitis

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