Abstract-Agile methods have become popular in recent years because the success rate of project development using Agile methods is better than structured design methods. Nevertheless, less than 50 percent of projects implemented using Agile methods are considered successful, and selecting the wrong Agile method is one of the reasons for project failure. Selecting the most appropriate Agile method is a challenging task because there are so many to choose from. In addition, potential adopters believe that migrating to an Agile method involves taking a drastic risk. Therefore, to assist project managers and other decision makers, this study aims to identify the key factors that should be considered when selecting an appropriate Agile method. A systematic literature review was performed to elicit these factors in an unbiased manner, and then content analysis was used to analyze the resultant data. It was found that the nature of the project, development team skills, project constraints, customer involvement and organizational culture are the key factors that should guide decision makers in the selection of an appropriate Agile method based on the value these factors have for different organizations and/or different projects.