Takotsubo (Ampulla-shaped) Cardiomyopathy Associated with Microscopic Polyangiitis

Abstract

Recently, a cardiac disorder characterized by ballooning and hypokinesis at the apex has been described as takotsubo (ampulla-shaped) cardiomyopathy. We encountered a patient with a rare case of takotsubo cardiomyopathy associated with microscopic polyangiitis.

Reversible Ventricular Dysfunction Takotsubo (ampulla-shaped) Cardiomyopathy

“…Treatment with an anti-inflammatory agent was remarkably effective for the systemic inflammation and focal cardiac damage in the case of Sato et al (12). We speculate that the treatment may have suppressed the excessive secretion of various cytokines.…”

“…Sato et al (12) published what we believe to be the first report of a case of takotsubo cardiomyopathy associated with microscopic polyangiitis. Based on their experience with this very rare case, they concluded that microscopic polyangiitis might be a causative factor of this disease.…”

“…Sato et al (12) performed the methylprednisolone pulse therapy in their patient with takotsubo cardiomyopathy. The high-dosage steroid infusion might reduce the secretion of norepinephrine, as well as suppress the production of cytokines.…”

“…This condition has come to be known as "takotsubo" cardiomyopathy (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Literature to date has included fairly frequent reports from Japan (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) and three reports from other parts of the world (13)(14)(15).…”

Two Cases of Ampulla (Takotsubo-Shaped) Cardiomyopathy Associated with Hemophagocytic Lymphohistiocytosis

“…In these reports, inflammatory infiltrates and myocyte necrosis were revealed in microscopic examination. There is a report of a case of ampulla cardiomyopathy associated with microscopic polyangiitis [22]. In that case, a large amount of steroid was effective.…”