Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice

Hesselbarth, Nico; Pettinelli, Chiara; Gericke, Martin; Berger, C; Kunath, Anne; Stümvoll, Michael; Blüher, Matthias; Klöting, Nora

doi:10.1016/j.bbrc.2015.07.015

Cited by 60 publications

(57 citation statements)

References 15 publications

(21 reference statements)

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“…In view of the results of the current study there is a significant increase in the level of serum Lipids when treated with TAM and elevation increased as the dose multiplied increased by the level of (30, 40, 50)mg/kg compared to the control group and this is consistent with [10][11][12][13].…”

Section: Discussionsupporting

confidence: 77%

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Study theeffect ofTamoxifenon Lipid profilein Male Albino Rats

H. Qasim,

H. Baraj

2021

Iraqi Journal of Science

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Tamoxifen(TAM) is an effective anticancer drug. This study was conducted to evaluate the side effects of Tamoxifenon the lipid profile. 40 rats divided into 4 equal groups,3 groups were given different doses (30, 40, 50)mg/kg body weight of TAM three times a week for 8 weeks as well as control group that was given with physiological solution.At the end ofexperiment, The results showed significant differences in the treated groups were the results showed a significant degrees (p<0.05) in the HDL level in the treatment group (50mg/kg) while the three groups showed a significant increase in the levels of (Ch, TG, LDL, VLDL). The results of the study showed that Tamoxifen caused an accumulation in fats.

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Section: Discussionsupporting

confidence: 77%

“…As for the HDL level, there was a significant decrease in the given dose of TAM and this reduction increased with increasing of dose compared with control group which has a significant increase in blood serum and this corresponds to the results [14,6,11].…”

Section: Discussionsupporting

confidence: 53%

Study theeffect ofTamoxifenon Lipid profilein Male Albino Rats

H. Qasim,

H. Baraj

2021

Iraqi Journal of Science

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“…While higher doses of tamoxifen have detrimental effects on WAT (Ye et al, 2015), reports are conflicting about how the lower tamoxifen dose used here affects WAT (Hesselbarth et al, 2015; Liu et al, 2015). To control for the potential effects of tamoxifen treatment in the Adiponectin-creER experiments, both SD and HFD groups were treated with tamoxifen.…”

Section: Discussionmentioning

confidence: 90%

The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity

et al. 2016

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Summary The sexually dimorphic distribution of adipose tissue influences the development of obesity-associated pathologies. The accumulation of visceral white adipose tissue (VWAT) that occurs in males is detrimental to metabolic health, while accumulation of subcutaneous adipose tissue (SWAT) seen in females may be protective. Here, we show that adipocyte hyperplasia contributes directly to the differential fat distribution between the sexes. In male mice, high-fat diet (HFD) induces adipogenesis specifically in VWAT, while in females HFD induces adipogenesis in both VWAT and SWAT in a sex hormone-dependent manner. We also show that the activation of adipocyte precursors (APs), which drives adipocyte hyperplasia in obesity, is regulated by the adipose depot microenvironment and not by cell-intrinsic mechanisms. These findings indicate that APs are plastic cells, which respond to both local and systemic signals that influence their differentiation potential independent of depot origin. Therefore, depot-specific AP microenvironment niches coordinate adipose tissue growth and distribution.

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“…Gli1 + cells represent a small population of the aortic arch (0.02% of all cells) (Fig 1C) and possess in vitro differentiation capacity towards osteoblasts, adipocytes and chondrocytes (Fig 1C). Since it has been recently reported that tamoxifen might induce browning of adipose tissue (Hesselbarth et al, 2015) and Gli1 + cells show adipogenic potential we tested whether tamoxifen might effect adipogenic differentiation of Gli1 + cells. Tamoxifen treatment of Gli1 + cells, however, did not show any effect on expression of the adipocyte marker FABP4 and brown fat marker UCP1 in Gli1 + cells (Figure S1).…”

Section: Resultsmentioning

confidence: 99%

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

et al. 2016

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Mesenchymal stem cell-like (MSC-like) cells reside in the vascular wall but their role in vascular regeneration and disease is poorly understood. Here, we show that Gli1+ cells located in the arterial adventitia are progenitors of vascular smooth muscle cells, and contribute to neointima formation and repair after acute injury to the femoral artery. Genetic fate tracing indicates that adventitial Gli1+ MSC-like cells migrate into the media and neointima during athero- and arteriosclerosis in ApoE−/− mice with chronic kidney disease. Our data indicate that Gli1+ cells are a major source of osteoblast-like cells during calcification in the media and intima. Genetic ablation of Gli1+ cells before induction of kidney injury dramatically reduced the severity of vascular calcification. These findings implicate Gli1+ cells as critical adventitial progenitors in vascular remodeling after acute and during chronic injury and suggest that they may be relevant therapeutic targets for mitigation of vascular calcification.

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Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice

Cited by 60 publications

References 15 publications

Study theeffect ofTamoxifenon Lipid profilein Male Albino Rats

Study theeffect ofTamoxifenon Lipid profilein Male Albino Rats

The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

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