Tandem Diels−Alder Cycloadditions in Organic Synthesis

Abstract

Contents I. Reactions of Bicyclic Bis-Dienes 168 II. Acetylenic Bis-Dienophiles 169 III. Exocyclic Bis-Dienes 169 IV. Equivalents of 3-Methylene-1,4-pentadiene and Related Species as Bis-Dienes 170 V. Masked Bis-Dienes 171 VI. Masked Bis-o-Quinodimethanes as Bis-Dienes 172 VII. Nonacetylenic Bis-Dienophiles 173 VIII. Tandem Cycloaddition Using Acyclic Bis-Dienes 173 IX. Conclusion 176

Photo-induced tandem cyclization of 3-iodoflavones with electron rich five-membered heteroarenes

“…Tandem cyclizations, as a powerful method for the synthesis of polycyclic compounds, have been successfully applied to the Diels-Alder reactions, [4][5][6][7] Michael addition, 8 rearrangements…”

An unexpected tandem cycloaddition reaction of α,β-unsaturated acid chloride with amines: Synthesis of dihydropyrancarboxamide derivatives and biological activity

“…IR spectra were recorded in KBr with an IR spectrophotometer Shimadzu 408. 1 H and 13 C NMR spectra were recorded on Varian EM-390 MHz spectrometer using TMS as internal reference and chemical shifts are expressed as δ ppm. Mass spectra were measured on a Shimadzu GCMS-QP 1000 Ex mass spectrometer.…”

“…There are several kinds of known organic reactions available to use in tandem cycloaddition reactions those are particularly attractive in organic synthesis [1][2][3][4][5]. Tandem reactions are referred to multistep one-pot reactions [6], these have many advantages over a series of individual reaction where it allow construction of complex structure in as few steps as possible, no need for a purification step, save on cost and amounts of reagents and reduce the amount of waste that is generated.…”

A green and convenient approach for the synthesis of 1,10-phenanthrolines via a catalyst- and solvent-free condition

“…Recent challenges in modern organic chemistry encompass the development of methodologies that afford assembly of molecular complexity and diversity in a fewer steps from readily available starting materials, under green conditions and with high yields (1)(2)(3)(4)(5). For this purpose, multicomponent domino reactions (MDRs) play an increasingly important role for the synthesis of chemically and biologically important compounds because of their high degree of atom economy, convergence, productivity, ease of execution, excellent yields, and green chemistry characteristic (6)(7)(8)(9)(10)(11)(12).…”