Tandem high-dose chemotherapy and autologous stem cell rescue in children with bilateral advanced retinoblastoma

Sh, Lee; Kh, Yoo; Kw, Sung; Jy, Kim; Cho, EJ; Hh, Koo; Se, Chung; Sw, Kang; Sy, Oh; Ham, Di; Yd, Kim

doi:10.1038/bmt.2008.181

Cited by 29 publications

(24 citation statements)

References 26 publications

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“…External beam radiotherapy is replaced with chemotherapy combined with focal therapy 14 15. Furthermore, high dose chemotherapy with stem cell support is performed as an investigational treatment for patients with metastatic disease 24. At present, the limits of chemotherapy for patients with a genetic predisposition to cancer have not been determined, and the best option is to follow patients meticulously to detect second or third malignant neoplasms as early as possible.…”

Section: Discussionmentioning

confidence: 99%

Treatment outcome of osteosarcoma after bilateral retinoblastoma: a retrospective study of eight cases

Lee¹,

Choi²,

Kang

et al. 2014

Br J Ophthalmol

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Section: Discussionmentioning

confidence: 99%

Treatment outcome of osteosarcoma after bilateral retinoblastoma: a retrospective study of eight cases

Lee¹,

Choi²,

Kang

et al. 2014

Br J Ophthalmol

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“…Even in recent years, various new attempts have been made in a different manner from the conventional treatment modalities. In recurred cases or advanced ones, hematopoietic stem cell transplantation following a high-dose chemotherapy has been reported to produce a good treatment outcome (5). Also at our institution, two patients were given hematopoietic stem cell transplantations.…”

Section: Discussionmentioning

confidence: 96%

“…Also the concomitant treatment regimens have been developed, the autologous hematopoietic stem cell transplantation following a high-dose chemotherapy (5,6) has been reported to produce a long-term survival of ＞90% in cases of progressive disease (7,8). As a result of these changes, the number of cases in which the eyeballs are preserved is also increasing (9).…”

Section: Methodsmentioning

confidence: 99%

Clinical Results of Chemotherapy based Treatment in Retinoblastoma Patients: A Single Center Experience

et al. 2008

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Purpose: Retinoblastoma is the most common intraocular malignancy in children. Since the 1990s, chemotherapy was indicated for intraocluar disease to reduce the frequency of enucleation and spare the complications associated with external beam radiation. In this study, we analyzed treatment results of retinoblastoma in our institute. Materials and Methods:Datas from children diagnosed with retinoblastoma and treated at Seoul National University Children's Hospital between 1986 and 2008 were analyzed retrospectively. We utilized cyclophosphamide, vincristine, adriamycin, and methotrexate (CVAM) for OPD-based adjuvant chemotherapy. From 1990, primary chemotherapy was administered to patients with intraocular disease for eyeball-saving and patients received a combination of etoposide, vincristine, cisplatin (or ifosfamide) as a moderately intensive regimen, or a combination of cisplatin, doxorubicin, etoposide, and cycophosphamide (CDEC) as a highly intensive regimen.Results: One hundred eighteen children were analyzed. There were 68 unilateral and 50 bilateral diseases. The median age at diagnosis was 1 year and ReeseEllsworth stage V was the most common stage at the time of diagnosis. All patients were treated by chemotherapy-based multimodality methods, and primary chemotherapy was administered to 80 patients. The 10-year overall and event-free survival rate of all patients were 93.9% and 91.6%, respectively. Two patients who died were in the CDEC regimen group, but there was no significant statistical difference in survival rates by chemotherapy regimens. Fifty-six of 114 eyeballs were saved after primary chemotherapy-based treatment, and the eyeball-saving rate was 49.1%. Six patients relapsed after enucleation and 2 patients were treated successfully after autologous PBSCT. Osteosarcoma occurred in 2 patients as a secondary malignancy, and facial asymmetry after radiotherapy was the most common long-term sequelae.Conclusions: In this study, the overall and event-free survival rates of retinoblastoma were satisfactory and eye-saving was possible with primary chemotherapy.

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“…[34] The introduction of stem cell rescue along with high dose chemotherapy has added another dimension to the treatment of orbital retinoblastoma. [38,39] The Children's Oncology Group trials (COG trials), currently taking place, has made a great effort to standardize the treatment protocols worldwide. Their welldesigned COG ARET 0321 trial of intensive multimodal therapy for extraocular retinoblastoma will probably lay to rest most of the confusion revolving around management protocols.…”

Section: New Frontiers Of the Futurementioning

confidence: 99%

Orbital retinoblastoma: Where do we go from here?

et al. 2011

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Diagnosis of orbital retinoblastoma traditionally carries a dismal prognosis. Although its incidence is less in the developed countries, it continues to contribute to an epidemic of extraocular disease at diagnosis in the developing world. Orbital retinoblastoma encompasses a wide range of distinct clinical entities with varying tumor load. There are no standard treatment protocols as of now but the current preferred management is multimodal with a combination of initial high-dose chemotherapy, surgery, external beam radiotherapy and prolonged chemotherapy for 12 cycles. Though orbital retinoblastoma is a catastrophic event, rapid advances on many fronts, especially the genetic, makes the future appear brighter than what it is now. This review looks at all the new frontiers that are in store in the near as well as the distant future. Looking at the ever expanding horizons makes one believe of a definite hope that one day we will conquer this disease as we have conquered many others in the past.

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Tandem high-dose chemotherapy and autologous stem cell rescue in children with bilateral advanced retinoblastoma

Cited by 29 publications

References 26 publications

Treatment outcome of osteosarcoma after bilateral retinoblastoma: a retrospective study of eight cases

Treatment outcome of osteosarcoma after bilateral retinoblastoma: a retrospective study of eight cases

Clinical Results of Chemotherapy based Treatment in Retinoblastoma Patients: A Single Center Experience

Orbital retinoblastoma: Where do we go from here?

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