Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17 cell response in mice

Li, Mengqin; Zhao, Yan; Qi, Di; He, Jing; Wang, Daoxin

doi:10.1016/j.micpath.2019.103826

Cited by 19 publications

(13 citation statements)

References 30 publications

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“…Pathological observation also indicated a reduced pathological reaction and inflammatory injury in lung tissue, which is consistent with previous results of PBLs in ALI. [23][24][25][26][27] Studies have shown that TNF-α mainly comes from monocytes and macrophages stimulated by LPS. 20,21,23,24 In the process of ALI resulting from various factors, TNF-α functions mainly through the following approaches.…”

Section: Discussionmentioning

confidence: 99%

“…[23][24][25][26][27] Studies have shown that TNF-α mainly comes from monocytes and macrophages stimulated by LPS. 20,21,23,24 In the process of ALI resulting from various factors, TNF-α functions mainly through the following approaches. First, it induces the production and release of proinflammatory cytokines, such as IL-6 and IL-8 that cause body damage.…”

Section: Discussionmentioning

confidence: 99%

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Effects of membrane-type PBLs on the expression of TNF-α and IL-2 in pulmonary tissue of SD rats after LPS-induced acute lung injury

Liu¹,

Jiang²,

Chen³

et al. 2022

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of membrane-type PBLs on the expression of TNF-α and IL-2 in pulmonary tissue of SD rats after LPS-induced acute lung injury

Liu¹,

Jiang²,

Chen³

et al. 2022

Adv Clin Exp Med

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“…Pharmacological studies have found that when applied to the digestive system, the efficacy of CRP is to ameliorate gastrointestinal smooth muscle activity, accelerate gastric emptying and intestinal push, alter gut microbiota, protect the esophagus and gastrointestinal mucosa and resist peptic ulcer [ 2 , 3 , 4 , 5 , 6 , 7 ]. To date, CRP has proven effects in the respiratory system, including but not limited to inhibiting airway inflammation, fighting acute lung injury and pulmonary fibrosis [ 8 , 9 , 10 , 11 , 12 , 13 ]. In terms of the cardiovascular system, CRP can improve cardiac insufficiency, alleviate cardiac hypertrophy and myocardial fibrosis, prevent hyperlipidemia and keep cardiomyocytes away from the damage of hypercholesterolemia [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Pharmacological Effects and Chemical Composition Of Crpmentioning

confidence: 99%

Mechanism of Citri Reticulatae Pericarpium as an Anticancer Agent from the Perspective of Flavonoids: A Review

et al. 2022

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Citri Reticulatae Pericarpium (CRP), also known as “chenpi”, is the most common qi-regulating drug in traditional Chinese medicine. It is often used to treat cough and indigestion, but in recent years, it has been found to have multi-faceted anti-cancer effects. This article reviews the pharmacology of CRP and the mechanism of the action of flavonoids, the key components of CRP, against cancers including breast cancer, lung cancer, prostate cancer, hepatic carcinoma, gastric cancer, colorectal cancer, esophageal cancer, cervical cancer, bladder cancer and other cancers with a high diagnosis rate. Finally, the specific roles of CRP in important phenotypes such as cell proliferation, apoptosis, autophagy and migration–invasion in cancer were analyzed, and the possible prospects and deficiencies of CRP as an anticancer agent were evaluated.

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“…A number of studies have previously shown that tangeretin exerts cytotoxic effects on various cancer cell types [ 12 ] and inhibits angiogenesis and metastasis. Furthermore, tangeretin has been reported to scavenge reactive radicals [ 13 ] and alleviate inflammation [ 14 ]. Cotreatment with tangeretin was also found to not only enhance the sensitivity of hepatoma carcinoma cells, colon carcinoma cells, and ovarian cancer cells to cisplatin [ 15 ] but also alleviate kidney damage caused by cisplatin [ 16 ] and the carcinogen dimethylbutyric acid [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Citrus Flavone Tangeretin Inhibits CRPC Cell Proliferation by Regulating Cx26, AKT, and AR Signaling

Zhang

Huang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Prostate cancer (PCa) progression depends on the action of androgen receptors (AR). Therefore, preventing ligand-mediated activation of AR is the first-line treatment strategy for metastatic PCa. Androgen deprivation therapy (ADT) can inhibit ligand binding to AR and alleviate PCa progression initially. However, due to the adaptation of PCa and recovery of AR signaling, castration-resistant prostate cancer (CRPC) eventually develops. Exploring novel dietary compounds that can target AR signaling appears to be a viable alternative therapeutic option for CRPC. In the present study, compounds from the citrus fruits were focused upon, which contain various flavonoid ingredients. Key components contained within orange peel, which is frequently used in traditional Chinese medicine, and downstream targets were first analyzed using network pharmacology approach. Notably, it was found that tangeretin, an active ingredient from orange peel, can significantly inhibit CRPC cell (C4-2 and Du145 cells) proliferation and migration whilst also synergistically increasing the sensitivity of CRPC cells to anti-tumor drugs sorafenib or cisplatin. Tangeretin also significantly reduced AR and AKT expressions in C4-2 cells and signal transducer and activator of transcription 3 expression in the androgen-insensitive cell line Du145. In addition, tangeretin increased the expression of both connexin26 (Cx26) and gap junction function, which may mediate the bystander effects of cisplatin or sorafenib. Taken together, the present study revealed a novel molecular mechanism by which tangeretin may inhibit the proliferation of CRPC cells, by affecting the Cx26/AKT/AR pathway, to synergistically increase the sensitivity of CRPC cells to sorafenib and cisplatin.

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Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17 cell response in mice

Cited by 19 publications

References 30 publications

Effects of membrane-type PBLs on the expression of TNF-α and IL-2 in pulmonary tissue of SD rats after LPS-induced acute lung injury

Effects of membrane-type PBLs on the expression of TNF-α and IL-2 in pulmonary tissue of SD rats after LPS-induced acute lung injury

Mechanism of Citri Reticulatae Pericarpium as an Anticancer Agent from the Perspective of Flavonoids: A Review

Citrus Flavone Tangeretin Inhibits CRPC Cell Proliferation by Regulating Cx26, AKT, and AR Signaling

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Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17 cell response in mice

Cited by 19 publications

References 30 publications

Effects of membrane-type PBLs on the expression of TNF-α and IL-2 in pulmonary tissue of SD rats after LPS-induced acute lung injury

Effects of membrane-type PBLs on the expression of TNF-α and IL-2 in pulmonary tissue of SD rats after LPS-induced acute lung injury

Mechanism of Citri Reticulatae Pericarpium as an Anticancer Agent from the Perspective of Flavonoids: A Review

Citrus Flavone Tangeretin Inhibits CRPC Cell Proliferation by Regulating Cx26, AKT, and AR Signaling

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Product

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Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17 cell response in mice