Tannic acid assisted anti-TNF-α nanobody assembly modulating the epithelial barrier dysregulation of allergic rhinitis

Fu, Shuilian; Cao, Zhi-Ting; Huang, Baolian; Yin, Te; Huang, Chujun; Bi, Zhiqian; Yao, Yingying; Chang, Xiaoyao; Zhuang, Hongqin; Hua, Zichun

doi:10.1007/s12274-023-5646-6

Cited by 4 publications

(1 citation statement)

References 47 publications

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“…This cascade triggers Th2 cell-mediated allergic responses and leads to the release of chemoattractant eotaxin-1 (CCL11) (29). Another study combined an anti-TNF-a nanobody (V) with tannic acid (V/ TA) as a functional antibody drug candidate and found that it could inhibit cytokine release in an ovalbumin (OVA)-induced AR murine model (30). In our study, the observed association between elevated levels of TNF-a and increased AR risk aligns with previous research findings.…”

Section: Discussionmentioning

confidence: 99%

Exploring causal relationships between inflammatory cytokines and allergic rhinitis, chronic rhinosinusitis, and nasal polyps: a Mendelian randomization study

Li,

Zhang,

Liu

et al. 2023

Front. Immunol.

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ObjectivesPrevious research has suggested connections between specific inflammatory cytokines and nasal conditions, including Allergic Rhinitis (AR), Chronic Rhinosinusitis (CRS), and Nasal Polyps (NP). However, a lack of robust research establishing the causal underpinnings of them. This Mendelian Randomization (MR) study aims to evaluate the causal relationships between 41 inflammatory cytokines and the incidence of AR, CRS and NP.MethodsThis study employed a two-sample MR design, harnessing genetic variations derived from publicly accessible genome-wide association studies (GWAS) datasets. AR data was sourced from a GWAS with 25,486 cases and 87,097 controls (identifier: ukb-b-7178). CRS data originated from a GWAS encompassing 1,179 cases and 360,015 controls (identifier: ukb-d-J32). NP data was extracted from a GWAS involving 1,637 cases and 335,562 controls (identifier: ukb-a-541). The data for 41 inflammatory cytokines were obtained from an independent GWAS encompassing 8,293 participants. Inverse variance weighted (IVW), MR Egger regression and Weighted median were used to evaluate the causalities of exposures and outcomes. A range of sensitivity analyses were implemented to assess the robustness of the results.ResultsThe results revealed significant associations between elevated circulating levels of MIP-1α (odds ratio, OR: 1.01798, 95% confidence interval, CI: 1.00217–1.03404, p = 0.02570) and TNF-α (OR: 1.01478, 95% CI: 1.00225–1.02746, p = 0.02067) with an augmented risk of AR in the IVW approach. Heightened levels of circulating IL-2 exhibited a positive correlation with an increased susceptibility to NP in the IVW approach (OR: 1.00129, 95% CI: 1.00017–1.00242, p = 0.02434), whereas elevated levels of circulating PDGF-BB demonstrated a decreased risk of NP (OR: 0.99920, 95% CI: 0.99841–0.99999, p = 0.047610). The MR analysis between levels of 41 inflammatory cytokines and the incidence of CRS yielded no positive outcomes.ConclusionThis investigation proposes a potential causal association between elevated levels of MIP-1α and TNF-α with an elevated risk of AR, as well as an increased risk of NP linked to elevated IL-2 levels. Furthermore, there appears to be a potential association between increased levels of circulating PDGF-BB and a reduced risk of NP.

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Section: Discussionmentioning

confidence: 99%

Exploring causal relationships between inflammatory cytokines and allergic rhinitis, chronic rhinosinusitis, and nasal polyps: a Mendelian randomization study

Li,

Zhang,

Liu

et al. 2023

Front. Immunol.

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Nanocomposite Hydrogel for Real‐Time Wound Status Monitoring and Comprehensive Treatment

Lei,

Yu,

Fan

2024

Advanced Science

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Current skin sensors or wound dressings fall short in addressing the complexities and challenges encountered in real‐world scenarios, lacking adequate capability to facilitate wound repair. The advancement of methodologies enabling early diagnosis, real‐time monitoring, and active regulation of drug delivery for timely comprehensive treatment holds paramount significance for complex chronic wounds. In this study, a nanocomposite hydrogel is devised for real‐time monitoring of wound condition and comprehensive treatment. Tannins and siRNA containing matrix metalloproteinase‐9 gene siRNA interference are self‐assembled to construct a degradable nanogel and modified with bovine serum albumin. The nanogel and pH indicator are encapsulated within a dual‐crosslinking hydrogel synthesized with norbornene dianhydride‐modified paramylon. The hydrogel exhibited excellent shape adaptability due to borate bonding, and the click polymerization reaction led to rapid in situ curing of the hydrogel. The system not only monitors pH, temperature, wound exudate alterations, and peristalsis during wound healing but also exhibits hemostatic, antimicrobial, anti‐inflammatory, and antioxidant properties, modulates macrophage polarization, and facilitates vascular tissue regeneration. This therapeutic approach, which integrates the monitoring of pathological parameters with comprehensive treatment, is anticipated to address the clinical issues and challenges associated with chronic diabetic wounds and infected wounds, offering broad prospects for application.

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Nanobody-as versatile tool emerging in autoimmune diseases

Wang,

Luo,

Zhang

et al. 2024

Smart Materials in Medicine

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Tannic acid assisted anti-TNF-α nanobody assembly modulating the epithelial barrier dysregulation of allergic rhinitis

Cited by 4 publications

References 47 publications

Exploring causal relationships between inflammatory cytokines and allergic rhinitis, chronic rhinosinusitis, and nasal polyps: a Mendelian randomization study

Exploring causal relationships between inflammatory cytokines and allergic rhinitis, chronic rhinosinusitis, and nasal polyps: a Mendelian randomization study

Nanocomposite Hydrogel for Real‐Time Wound Status Monitoring and Comprehensive Treatment

Nanobody-as versatile tool emerging in autoimmune diseases

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