Tannic acid enhances cisplatin effect on cell proliferation and apoptosis of human osteosarcoma cell line (U2OS)

Kasiram, Mohamad Zahid; Hapidin, Hermizi; Abdullah, Huda; Hashim, Nor Munira; Ahmad, Azlina; Sulong, Sarina

doi:10.1007/s43440-021-00330-3

Cited by 2 publications

(1 citation statement)

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“…It is reported that the combined use of HT and cisplatin in HepG2 cells resulted in mitochondria‐mediated apoptosis and effective inhibition of cell growth compared with treatment with cisplatin alone (Geng et al, 2019). HT enhances the cisplatin effect in human osteosarcoma cell lines by elevating the percentage of apoptosis cells, aggravating chromosomal condensation and nuclear fragmentation, and narrowing the nuclear volume (Kasiram et al, 2021). Furthermore, HT has been proven to be a safe drug, as they have no negative influence on normal human cells.…”

Section: Hydrolysable Tanninsmentioning

confidence: 99%

Hydrolysable tannins as a potential therapeutic drug for the human fibrosis‐associated disease

Wang

Cao

2023

Drug Development Research

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Fibrosis is a pathological change with abnormal tissue regeneration due to a response to persistent injury, which is extensively related to organ damage and failure, leading to high morbidity and mortality worldwide. Although the pathogenesis of fibrosis has been comprehensively elucidated, there are few effective therapies for treating fibrotic diseases. Natural products are increasingly regarded as an effective strategy for fibrosis with numerous favorable functions. Hydrolysable tannins (HT) are a type of natural products that have the potential to treat the fibrotic disease. In this review, we describe some biological activities and the therapeutic prospects of HT in organ fibrosis. Furthermore, the underlying mechanisms of inhibition of HT on fibrotic organs in relation to inflammation, oxidative stress, epithelial–mesenchymal transition, fibroblast activation and proliferation, and extracellular matrix accumulation are discussed. Understanding the mechanism of HT against fibrotic diseases will provide a new strategy for the prevention and attenuation of fibrosis progression.

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Section: Hydrolysable Tanninsmentioning

confidence: 99%