Tannic acid-modified magnetic hydrotalcite-based MgAl nanoparticles for the in vitro targeted delivery of doxorubicin to the estrogen receptor-overexpressing colorectal cancer cells

Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

“…Regarding their indication, DOX-containing DDSs were developed for a wide variety of cancers, including breast cancer [ 123 , 147 , 150 ], liver cancer [ 131 , 133 , 145 ], lung cancer [ 151 ], and colorectal carcinoma [ 129 , 132 , 152 ].…”

“…The in vitro release showed a pH-dependent biphasic and sustained release of DOX, while the safety and biocompatibility of the DDS were confirmed using hemolysis and MTT assays. Furthermore, higher cellular uptake in ER-positive HCT116 and LoVo cells was observed [ 152 ]. The development of a magnetic dual-responsive nanocarrier for targeted drug delivery to cancer cells overexpressing the DNA repair enzyme APE1 was described ( Figure 3 B).…”

Estrogen receptor-mediated health benefits of phytochemicals: a review

“…As polyphenols in plants, many tannins have been proven to be agonists or SERMs and are prescribed for the treatment of breast cancer, like tannin acid, a deca-galloyl glucose, which activates caspases 9 and 7 to induce apoptosis in breast epithelial cells and has a significant therapeutic effect on breast cancer. 63 In addition to tannin acid, ellagic acid is also a hot topic of research lately. Ellagic acid induces osteoblast mineralization and inhibits estrogen-mediated activity by increasing insulin-like growth factor binding protein-3 (IGFBP-3) production in breast cancer cells, acting as an agonist in osteoblasts, but is antagonistic in breast cancer cells.…”

Tannic Acid-Modified MXene as a Nanocarrier for the Delivery of β-Cyfluthrin as a Sustained Release Insecticide

“…Tannic acid (TA) is a natural plant polyphenol, which has good interfacial affinity . It can form a thin film on the surface of materials by self-polymerization to improve the interfacial affinity of materials. , In addition, the TA-based drug delivery system also has pH-responsive controlled release performance, which can control the release behavior of drugs by adjusting the pH value so as to achieve accurate drug delivery and improve the utilization of drugs. , Therefore, in the current research, we designed a TA-modified MXene nanocarrier for pyrethroid (e.g., β-CYF) delivery and investigated its physical and chemical properties and insecticidal activity (Scheme ). TA was decorated on the surface of MXene by self-polymerization, and then β-CYF was loaded on the carrier, forming a uniform nanopesticide formulation (MXene-TA-β-CYF) with good water dispersion stability.…”