Tannin–Mn coordination polymer coated carbon quantum dots nanocomposite for fluorescence and magnetic resonance bimodal imaging

Abstract

The MR/FI bimodal imaging has attracted widely studied due to combining the advantages of MRI and FI can bridge gaps in sensitivity and depth between these two modalities. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by coating the Mn-phenolic coordination polymer on the surface of the carbon quantum dots. The structure of the as-prepared nanocomposite probe is carefully validated via SEM, TEM, and XPS. The content of Mn2+ is calculated through the EDS and TGA. The quantum yield (QY) and emission wavelength of the probe are about 7.24% and 490 nm, respectively. The longitudinal r1 value (2.43 mM−1 s−1) with low r2/r1 (4.45) of the probe is obtained. Subsequently, fluorescence and MR imaging are performed. The metabolic pathways in vivo are inferred by studying the bio-distribution of the probe in major organs. Thus, these results indicate that probe would be an excellent dual-modal imaging probe for enhanced MR imaging and fluorescence imaging.

Carbon dot/inorganic nanomaterial composites

“…In conclusion, as a therapeutic platform with good biocompatibility and photothermal properties, CDs and metal nanoparticle hybrid materials can be widely used in drug delivery, photothermal/photodynamic therapy, and biological antibacterial treatment elds. [94][95][96] Metal oxide/CDs Metal oxide nanoparticles have attracted much attention due to their stability, relatively low production cost, and functional properties in various elds. 22 Based on the excellent application performance of metal oxide nanoparticles, many researchers compound them with CDs, which have rich surface defects, a wide wavelength range of light absorption, visible solid light absorption, up-conversion luminescence, and other characteristics, to construct a series of CDs and oxide hybrid materials.…”

“…In conclusion, as a therapeutic platform with good biocompatibility and photothermal properties, CDs and metal nanoparticle hybrid materials can be widely used in drug delivery, photothermal/photodynamic therapy, and biological antibacterial treatment fields. 94–96…”

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

“…96 A nanocomposite was constructed from a tannin− manganese (Mn) coordination polymer and carbon quantum dots for fluorescence and MRI bimodal imaging. 97 The longitudinal r 1 value was ∼2.43 mM −1 s −1 , and there were excellent bright-orange fluorescence features with a quantum yield of ∼7.24%. These probes could simply enter the body of mice and slowly attenuated with time, offering promising dualmodal imaging probes for MRI and fluorescence imaging with high efficiency.…”

“…A nanocomposite was constructed from a tannin–manganese (Mn) coordination polymer and carbon quantum dots for fluorescence and MRI bimodal imaging . The longitudinal r 1 value was ∼2.43 mM –1 s –1 , and there were excellent bright-orange fluorescence features with a quantum yield of ∼7.24%.…”

“…The longitudinal r 1 value was ∼2.43 mM –1 s –1 , and there were excellent bright-orange fluorescence features with a quantum yield of ∼7.24%. These probes could simply enter the body of mice and slowly attenuated with time, offering promising dual-modal imaging probes for MRI and fluorescence imaging with high efficiency . Fe-coordinated carbon nanozyme dots were synthesized as T 2 -weighted MRI NCAs.…”