Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway

Yuan, Fengyi; Zhang, Min; Xu, Ping; Xu, Dan; Chen, Ping; Ren, Min; Sun, Qi; Chen, Jingyan; Du, Juan; Tang, Xin

doi:10.3892/etm.2018.6674

“…100 Jiang et al study revealed that the underlined compound significantly blocks the up-regulation of iNOS, matrix metalloproteinase-2 (MMP-2) as well as NF-κB/ p65 in the RNA and protein expression levels of AD rats through the NF-κB pathway to reduces AD risk. 86 In summary, the underlined data indicate a more theoretical basis for the effective treatment of tan-IIA on behalf of neurodegenerative diseases and introduce a new perspective for the AD clinical treatment.…”

Section: Anti-inflammationmentioning

confidence: 92%

“…Yuan et al studies have shown that in experimental rats, the underlined compound prevents inflammatory processes and overcome symptoms of Type 2 diabetes through 5ʹ AMPK signaling cascade stimulated via NF-κB. 86 Feng et al proved that the neuropathic pain in diabetic rats' model has been lowered by tan-IIA through stimulating the Nrf2/ARE signaling cascade and attenuating the NF-kB signaling cascade. 78 Sun et al study showed that tan-IIA has remarkable cardioprotective effects given the diabetic cardiomyopathy.…”

Section: Anti-inflammationmentioning

confidence: 99%

<p>Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases</p>

Guo

¹

,

Li

²

,

Su

³

et al. 2020

DDDT

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Salvia miltiorrhiza : (Danshen) is a significant (traditional Chinese medication) natural remedy, enhancing blood circulation and clear blood stasis. In this view, it is widely used against several heart diseases, eg, cardiomyopathy, arrhythmia, and congenital heart defects. Tanshinone IIA (tan-IIA) is the main fat-soluble component of Salvia miltiorrhiza . Modern pharmacological study shows that tan-IIA has anti-inflammatory and anti-oxidant activities. Tan-IIA induces remarkable cardioprotective effects via enhancing angiogenesis which may serve as an effective treatment against cardiovascular diseases (CVD). There is also evidence that tan-IIA has extensive immunomodulatory effects and plays a significant role in the development and function of immune cells. Tan-IIA reduces the production of inflammatory mediators and restores abnormal signaling pathways via regulating the function and activation of immune cells. It can also regulate signal transduction pathways, ie, TLR/NF-κB pathway and MAPKs/NF-κB pathway, thereby tan-IIA has an anti-inflammatory, anticoagulant, antithrombotic and neuroprotective role. It plays a protective role in the pathogenesis of cardiovascular disorders (ie, atherosclerosis, hypertension) and Alzheimer’s disease. It has also been revealed that tan-IIA has an anti-tumor role by killing various tumor cells, inducing differentiation and apoptosis, and has potential activity against carcinoma progression. In the review of this fact, the tan-IIA role in different diseases and its mechanism have been summarized while its clinical applications are also explored to provide a new perspective of Salvia miltiorrhiza . An extensive study on the mechanism of action of tan-IIA is of great significance for the effective use of Chinese herbal medicine and the promotion of its status and influence on the world.

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“…e imbalance of adipose cytokines such as leptin and adiponectin secreted by adipose tissue in obese patients also aggravates the IR associated with PCOS [50]. S. miltiorrhiza Evidence-Based Complementary and Alternative Medicine extract increases the sensitivity to insulin by inducing the production and secretion of anti-inflammatory adipokines (such as APN), and it reduces inflammation and the production of proinflammatory cytokines [51,52]. Tanshinone I may also decrease fasting blood glucose concentrations by decreasing levels of interleukin-6 and tumor necrosis factoralpha and by reducing the nuclear translocation of NF-κB and the phosphorylation of Ser307 on insulin receptor substrate 1 (IRS-1) [42].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Salvia miltiorrhiza on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Shen

¹

,

Jin

²

,

Yaguang

³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. As a traditional medicine, Salvia miltiorrhiza (S. miltiorrhiza) has been widely used in the treatment of many gynecological diseases, but the efficacy of S. miltiorrhiza in women with PCOS has not been assessed. The purpose of this systematic review and meta-analysis was to evaluate the effectiveness and safety of S. miltiorrhiza in women with PCOS. Methods. We conducted searches in PubMed, Embase, the Cochrane Library, the China National Knowledge Infrastructure, the Wanfang Database, the Chinese Scientific Journal Database, and the Chinese BioMedical database from inception to December 23, 2020, to identify studies that met the inclusion criteria. The quality of the evidence was estimated using the Cochrane Reviewer Handbook 5.0.0, and the meta-analysis was performed using RevMan 5.3.5 software. Results. Six randomized controlled trials (RCTs) involving 390 patients with PCOS were included. The studies suggested that S. miltiorrhiza extract combined with letrozole (LET) was more effective in improving pregnancy rate (RR: 2.60, 95% CI: 1.06 to 6.39, P = 0.04 ) compared to LET alone. S. miltiorrhiza extract was associated with decreased fasting blood glucose (MD: –0.25, 95% CI: –0.37 to –0.13, P < 0.0001 ), fasting insulin (MD: –1.16, 95% CI: –1.74 to –0.58, P < 0.0001 ), total cholesterol (TC) (MD: –0.58, 95% CI: –0.72 to –0.43, P < 0.00001 ), and triglycerides (TG) (MD: –0.31, 95% CI: –0.35 to –0.26, P < 0.00001 ) compared with placebo, but not with improvements in body mass index or waist-to-hip ratio (MD: –1.41, 95% CI: –4.81 to 2.00, P = 0.42 ; MD: –0.02, 95% CI: –0.05 to 0.01, P = 0.16 , respectively). There was a significant difference between S. miltiorrhiza extract combined with cyproterone acetate (CPA) and CPA alone in terms of decreasing TC (MD: –0.77, 95% CI: –0.89 to –0.65, P < 0.00001 ), TG (MD: –0.43, 95% CI: –0.65 to –0.20, P < 0.0001 ), and low-density lipoprotein cholesterol (MD: –0.49, 95% CI: –0.66 to –0.33, P < 0.00001 ) and increasing high-density lipoprotein cholesterol (MD: 0.30, 95% CI: 0.20, 0.40, P < 0.00001 ). In addition, S. miltiorrhiza extract also decreased testosterone, follicle-stimulating hormone, and luteinizing hormone. The studies did not mention any adverse events with S. miltiorrhiza extract. Conclusion. The current studies indicate that S. miltiorrhiza has beneficial effects on reproduction and glucose and lipid metabolism in patients with PCOS, and it is generally safe for clinical application. However, more prospective RCTs with large samples, multiple centers, and longer intervention duration are needed in the future to obtain more reliable conclusions.

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“…In addition, it markedly reduced the tubuloid interstitial accumulation of fibronectin and collagen I ( Jiang et al, 2016 ) and reversed the HG-induced increase in α-SMA and decrease in E-cadherin, thereby reducing renal proximal tubular fibrosis ( Cao et al, 2017 ). Tan IIA treatment increased immune cell precipitation in renal cells and improved the lipid and glucose metabolism, insulin resistance, and body weight in type 2 DM Rats ( Yuan et al, 2018 ), attenuates renal injury by reducing excessive oxidative stress and inflammation, and the mechanisms include activating Nrf2, and upregulating heme oxygenase-1 (HO-1) expression ( Liang et al, 2018 ), and enhancement of glutathione mediated detoxification pathways ( Li W. et al, 2019 ). Summarily, the affected targets by Tan IIA against urinary system diseases were shown in Figure 2 .…”

Section: Urinary Systemmentioning

confidence: 99%

Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA

Zhong

¹

,

Lin

²

,

Ke

³

et al. 2021

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Tanshinone IIA (Tan IIA) is an important characteristic component and active ingredient in Salvia miltiorrhiza, and its various aspects of research are constantly being updated to explore its potential application. In this paper, we review the recent progress on pharmacological activities and the therapeutic mechanisms of Tan IIA according to literature during the years 2015–2021. Tan IIA shows multiple pharmacological effects, including anticarcinogenic, cardiovascular, nervous, respiratory, urinary, digestive, and motor systems activities. Tan IIA modulates multi-targets referring to Nrf2, AMPK, GSK-3β, EGFR, CD36, HO-1, NOX4, Beclin-1, TLR4, TNF-α, STAT3, Caspase-3, and bcl-2 proteins and multi-pathways including NF-κB, SIRT1/PGC1α, MAPK, SREBP-2/Pcsk9, Wnt, PI3K/Akt/mTOR pathways, TGF-β/Smad and Hippo/YAP pathways, etc., which directly or indirectly influence disease course. Further, with the reported targets, the potential effects and possible mechanisms of Tan IIA against diseases were predicted by bioinformatic analysis. This paper provides new insights into the therapeutic effects and mechanisms of Tan IIA against diseases.

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Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway

Cited by 10 publications

References 29 publications

<p>Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases</p>

<p>Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases</p>

The Effects of Salvia miltiorrhiza on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA

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