Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy

Mannelli, Lorenzo Di Cesare; Piccolo, Marialuisa; Μaione, Francesco; Ferraro, Maria Grazia; Irace, Carlo; Feo, Vincenzo De; Ghelardini, Carla; Mascolo, Nicola

doi:10.1016/j.biopha.2018.06.047

Cited by 51 publications

(18 citation statements)

References 52 publications

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“…TIIA was one of the effective compounds derived from the root of Danshen. Di Cesare Mannelli et al 21 noticed that Danshen, TIIA and cryptotanshinone could separately attenuate chemotherapy-induced neuropathic pain in animal model, and TIIA could also reveal anti-proliferation /cytotoxicity activity in glioblastoma LN-229 and U-87 MG cells. It had been reported that TIIA exerted its anticancer activity in glioma through modulating growth, differentiation, migration, apoptosis, and autophagy via signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

<p>Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis</p>

You¹,

He²,

Wang³

et al. 2020

CMAR

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Background: Tanshinone IIA (TIIA) is one of the active constituents derived from the rhizome of Danshen, a traditional Chinese herbal. Recently, microRNAs (miRNAs) have been suggested to be associated with the anticancer role of TIIA. However, it remains vague of the interaction between miRNAs and TIIA in glioma, a common aggressive brain tumor in humans. Methods: Expression of miRNA (miR)-16-5p and talin-1 (TLN1) was detected using reverse transcription-quantitative polymerase chain reaction and Western blotting. Cell proliferation, migration and invasion were assessed with cell viability assay, transwell assay, Western blotting, and xenograft tumor experiment. The target binding between miR-16-5p and TLN1 was confirmed by dual-luciferase reporter assay and RNA pull-down assay. Results: TIIA treatment inhibited cell viability, migration and invasion, and decreased Cyclin D1, matrix metalloproteinase (MMP)-9 and Vimentin expression in glioma T98G and A172 cells both in vitro and in vivo. Thus, TIIA induced anti-glioma role, wherein miR-16-5p was upregulated and TLN1 was downregulated. Moreover, silencing miR-16-5p could abate TIIA-mediated suppression on glioma cell proliferation, migration and invasion in vitro and in vivo. TLN1 overexpression also exerted tumor-promoting effect in TIIA-treated T98G and A172 cells. Mechanically, miR-16-5p could regulate TLN1 expression via target binding, and depleting TLN1 could counteract the inhibitory effect of miR-16-5p knockdown on the curative effect of TIIA in T98G and A172 cells. Conclusion: TIIA exerted the anti-proliferation, anti-migration and anti-invasion role in glioma cells both in vitro and in vivo partially through regulating miR-16-5p/TLN1 axis.

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Section: Discussionmentioning

confidence: 99%

<p>Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis</p>

You¹,

He²,

Wang³

et al. 2020

CMAR

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“…The active components of S. miltiorrhiza are divided into two groups, one of which is water-soluble phenolics including salvianolic acid A (Sal A), salvianolic acid B (Sal B), lithospermic acid, rosmarinic acid, and R-(+)-β-(3,4-dihydroxyphenyl)lactic acid, named danshensu [ 3 ] and the other is lipophilic tanshinones including tanshinone I, tanshinone IIA, tanshinone IIB, cryptotanshinone, and dihydrotanshinone I [ 4 ]. Salvianolic acids (including Sal A and Sal B), the most abundant compounds from S. miltiorrhiza , are known to exhibit diverse biological activities such as antioxidant [ 5 ], anti-inflammatory [ 6 ], antithrombotic [ 7 ], and cardioprotective activities [ 8 , 9 ], while tanshinones show antitumor [ 10 ], cardioprotective [ 11 ], neuroprotective and analgesic activities [ 12 ], and so forth.…”

Section: Salvia Miltiorrhiza Bungementioning

confidence: 99%

Overview of Salvia miltiorrhiza as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action

et al. 2020

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Salvia miltiorrhiza Bunge (S. miltiorrhiza) is a medicinal herb that has been used for the treatment for various diseases such as cardiovascular and cerebrovascular diseases in East Asia including Korea. Considering its extensive usage as a therapeutic agent for multiple diseases, there is a need to review previous research regarding its therapeutic benefits and their mechanisms. Therefore, we searched PubMed and PubMed Central for articles reporting its therapeutic effects on certain disease groups including cancers, cardiovascular, liver, and nervous system diseases. This review provides an overview of therapeutic benefits and targets of S. miltiorrhiza, including inflammation, fibrosis, oxidative stress, and apoptosis. The findings on multi-functional properties of S. miltiorrhiza discussed in this article support the efficacy of S. miltiorrhiza extract on various diseases, but also call for further research on the multiple mechanisms that mediate its therapeutic effects.

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“…Salvia miltiorrhiza Bunge (SMB, Danshen in Chinese), belonging to Labiate family (Kai et al 2011;Shi et al 2014), is an important traditional Chinese herbal plant with long history for medicine as well as healthy food (Shi et al 2018). It has been used clinically to treat cardiovascular diseases (Wang et al 2017a(Wang et al , b, 2018Chen and Chen 2017;Fang et al 2018) and displays anti-inflammation (Gao et al 2018;Wu et al 2018), neuro-protection (Di et al 2018;Saroya and Singh 2018), cardio-protection (Hu et al 2012;Weng et al 2013) and anticancer activities (Wang et al 2017a, b;Uto et al 2018;Qiu et al 2018;Hsieh et al 2018). There are two major types of pharmacologically active compounds present in SMB, one is water-soluble phenolic acids (Ma et al 2013), and the other is fat-soluble ketones (Kim et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Application of 1H-NMR combined with qRT-PCR technology in the exploration of rosmarinic acid biosynthesis in hair roots of Salvia miltiorrhiza Bunge and Salvia castanea f. tomentosa Stib

Hou

Feng

et al. 2020

Planta

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Main conclusion Methyl jasmonate promotes the synthesis of rosmarinic acid in Salvia miltiorrhiza Bunge and Salvia castanea f. tomentosa Stib, and it promotes the latter more strongly. Abstract Salvia miltiorrhiza Bunge (SMB) is a traditional Chinese medicinal material, its water-soluble phenolic acid component rosmarinic acid has very important medicinal value. Salvia castanea f. tomentosa Stib (SCT) mainly distributed in Nyingchi, Tibet. Its pharmacological effects are similar to SMB, but its rosmarinic acid is significantly higher than the former. Methyl jasmonate (MJ) as an inducer can induce the synthesis of phenolic acids in SMB and SCT. However, the role of MJ on rosmarinic acid in SMB is controversial. Therefore, this study used SMB and SCT hair root as an experimental material and MJ as a variable. On one hand, exploring the controversial reports in SMB; on the other hand, comparing the differences in the mechanism of action of MJ on the phenolic acids in SMB and SCT. The content of related metabolites and the expression of key genes in the synthesis pathway of rosmarinic acid was analyzed by 1H-NMR combined with qRT-PCR technology. Our research has reached the following conclusions: first of all, MJ promotes the accumulation of rosmarinic acid and related phenolic acids in the metabolic pathways of SMB and SCT. After MJ treatment, the content of related components and gene expression are increased. Second, compared to SMB, SCT has a stronger response to MJ. It is speculated that the different responses of secondary metabolism-related genes to MJ may lead to different metabolic responses of salvianolic acid between the two.

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Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy

Cited by 51 publications

References 52 publications

<p>Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis</p>

<p>Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis</p>

Overview of Salvia miltiorrhiza as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action

Application of 1H-NMR combined with qRT-PCR technology in the exploration of rosmarinic acid biosynthesis in hair roots of Salvia miltiorrhiza Bunge and Salvia castanea f. tomentosa Stib

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