Tao brush endometrial cytology is a sensitive diagnostic tool for cancer and hyperplasia among women presenting to clinic with abnormal uterine bleeding

Abstract

This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Accuracy of cytological examination of Tao brush endometrial sampling in diagnosing endometrial premalignancy and malignancy

“…111 articles were evaluated for eligibility after abstracts screening. Lastly, five studies with 774 patients were included in the systematic review and meta‐analysis 18 , 19 , 24 , 25 , 26 (Figure S1 ).…”

“…In the “Patient selection” domain, two studies were judged at high risk of bias because they did not consecutively include all eligible patients in the study period, 18 , 24 while the remaining studies were considered at low risk. 19 , 25 , 26 …”

“…In the “Index test” domain, one study was considered at unclear risk of bias because the Tao brush technique was not described, 18 while the remaining studies were considered at low risk of bias. 19 , 24 , 25 , 26 …”

“…111 articles were evaluated for eligibility after abstracts screening. Lastly, five studies with 774 patients were included in the systematic review and meta-analysis 18,19,[24][25][26] (Figure S1). Among included studies, four studies were designed as observational prospective cohort studies and one study was designed as observational retrospective cohort study (Table S1).…”

“…19,25,26 In the "Index test" domain, one study was considered at unclear risk of bias because the Tao brush technique was not described, 18 while the remaining studies were considered at low risk of bias. 19,[24][25][26] In the "Reference standard" domain, one study was considered at high risk of bias because the reference standard was D&C and not hysterectomy, 25 three studies were considered at unclear risk of bias because the reference standard was either D&C or hysterectomy, 18,19,26 while the remaining study was considered at low risk of bias. 24 In the "flow and timing" domain, all the studies were considered at low risk of bias.…”