TAp63 is correlated with chronic inflammation in patients with newly diagnosed type 2 diabetes mellitus

Hu, Xuemei; Liu, Jie; Sun, Li; Liu, Linjie; Hu, Yimeng; Yuan, Yin; Wu, Guijun; Wang, Ye; Chen, Jing; Xu, Yancheng

doi:10.1016/j.jdiacomp.2017.12.013

Cited by 3 publications

(2 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Persistent inflammation can lead to the chronic phase [ 65 ]. Chronic inflammation contributes to immune diseases [ 66 ], arthritis, diabetes, cancer [ 67 ], cardiovascular and neurodegenerative diseases [ 8 , 68 ] and many other chronic diseases [ 69 , 70 , 71 ].…”

Section: Role Of Punicalagin In Inflammation-associated Diseasesmentioning

confidence: 99%

Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases

Cao

Liu

et al. 2021

Antioxidants

View full text Add to dashboard Cite

Inflammation is a complex biological defense system associated with a series of chronic diseases such as cancer, arthritis, diabetes, cardiovascular and neurodegenerative diseases. The extracts of pomegranate fruit and peel have been reported to possess health-beneficial properties in inflammation-associated chronic diseases. Punicalagin is considered to be the major active component of pomegranate extracts. In this review we have focused on recent studies into the therapeutic effects of punicalagin on inflammation-associated chronic diseases and the regulatory roles in NF-κB, MAPK, IL-6/JAK/STAT3 and PI3K/Akt/mTOR signaling pathways. We have concluded that punicalagin may be a promising therapeutic compound in preventing and treating inflammation-associated chronic diseases, although further clinical studies are required.

show abstract

Section: Role Of Punicalagin In Inflammation-associated Diseasesmentioning

confidence: 99%

Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases

Cao

Liu

et al. 2021

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Modern pharmacological investigations reveal that total glycosides of the leaves of Rehmannia (DHYZG) exhibits a spectrum of biological activities, including neuroprotective [1] immunomodulatory, [2] anti-inflammatory, [3] anti-tumor, [4] anti-thrombotic, [5] antioxidant, and liver-protective [6] effects. The terpenoids in Dihuang leaves emerge as key players in regulating blood sugar [7] and impeding malignant tumor [8] development. Furthermore, flavonoids in Dihuang leaves showcase diverse pharmacological activities, encompassing antioxidation, anti-inflammation, anti-apoptosis, [9] anti-atherosclerosis, [10] analgesic, anti-inflammatory, [11] immune enhancement, [12] as well as the regulation of blood sugar, [13] lipids, [14] blood pressure, and vascular dilation.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Acteoside and Total Glycosides of the Leaves of Rehmannia on Three Types of Glomerular Structural Cells Under High Glucose and Inflammatory Stimulation

Liu,

Gao,

Wang

et al. 2024

Integr Med Nephrol Androl

View full text Add to dashboard Cite

Background: The challenge of chronic glomerulonephritis necessitates innovative strategies for preventing renal function deterioration. Acteoside (ACT), the primary bioactive compound of total glycosides of the leaves of Rehmannia (DHYZG), has been demonstrated availability and safety in reducing proteinuria, showing promising prospects in the treatment of kidney disease. This study aimed to elucidate the impact of ACT and DHYZG on glomerular structural cells and key proteins of rat glomeruli under several injury states. Methods: Employing 3-(4,5)-dimethylthiazolyl(-Z-Y1)-3,5-diphenyltetrazolium bromide (MTT) and Western blot methodologies, the investigation assessed varying concentrations of ACT and clinical concentration of DHYZG on cell viability and intracellular biomarkers. Specifically, the study explored the influence of ACT on connective tissue growth factor (CTGF), transforming growth factor-β (TGF-β), matrix metalloproteinase-2 (MMP-2), and MPP in rat mesangial cells, endothelial cells, and podocytes stimulated by lipopolysaccharide (LPS), high glucose, and interleukin-1β (IL-1β). Additionally, the impact of high glucose on angiotensin II (Ang II) expression in endothelial cells was investigated. Results: ACT and DHYZG demonstrated a protective effect on all cell types, and ACT administration shows a significant dose-dependent response. These compounds attenuated the expression of CTGF and TGF-β in LPS-stimulated mesangial cells and reduced the expression of MMP-2 and MMP-9 in all three cell types following IL-1β stimulation. Moreover, the high glucose-induced expression of Ang II in endothelial cells was mitigated. Conclusion: ACT and DHYZG exhibit a pronounced protective effect on glomerular cells, with ACT being the primary contributor to the therapeutic efficacy of DHYZG. Notably, ACT demonstrates a significant superiority over DHYZG in terms of both proliferation and cytokine expression in glomerular endothelial cells.

show abstract

Puerarin suppresses the hepatic gluconeogenesis via activation of PI3K/Akt signaling pathway in diabetic rats and HepG2 cells

Qing

Qiu

Chen

et al. 2021

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

TAp63 is correlated with chronic inflammation in patients with newly diagnosed type 2 diabetes mellitus

Cited by 3 publications

References 35 publications

Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases

Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases

The Protective Effects of Acteoside and Total Glycosides of the Leaves of Rehmannia on Three Types of Glomerular Structural Cells Under High Glucose and Inflammatory Stimulation

Puerarin suppresses the hepatic gluconeogenesis via activation of PI3K/Akt signaling pathway in diabetic rats and HepG2 cells

Contact Info

Product

Resources

About