Taquicardia ventricular y QT largo asociados a la administración de claritromicina en un paciente afectado de infección por el VIH

Camazón, Nuria Vallejo; Pardo, Dolors; Hidalgo, Antonio Sánchez; Mas, M.; Ribera, Esteban; Soler, Jordi Soler

doi:10.1016/s0300-8932(02)76720-1

Cited by 20 publications

(1 citation statement)

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“… 53 Vallejo reported the case of an HIV-positive patient treated with intravenous cotrimoxazole and clarithromycin for HIV-associated opportunistic infections developing QT prolongation and ventricular arrhythmia. 54 Antipsychotic drugs are also commonly used to combat the mental conditions in HIV-infected and AIDS patients. Certain psychiatric medications such as haloperidol, clothiapine, phenothiazines, citalopram, and escitalopram have been shown to induce QT prolongation in adult psychiatric patients with HIV infection or viral hepatic infection.…”

Section: Resultsmentioning

confidence: 99%

QT prolongation in HIV-positive patients: Review article

Liu

Shah

Basu‐Ray³

et al. 2019

Indian Heart Journal

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Introduction Antiretrovirals have immensely increased the average life expectancy of HIV-positive patients. However, the incidence of QT interval prolongation and other arrhythmias has also increased. Methods Pubmed and Google Scholar were searched for relevant literature published between 1990 and 2019. Results and discussion HIV-positive patients with high viral load, low CD4 count, chronic inflammation, and autonomic neuropathy can develop QT interval prolongation. Another factor prolonging QT interval includes exposure to the HIV transactivator protein, which inhibits hERG K (+) channels controlling IKr K (+) currents in cardiomyocytes. Protease inhibitors inhibiting the CYP3A4 enzyme can also lead to QT interval prolongation. QT interval prolongation can potentially be exacerbated by opioids, antipsychotics, antibiotics, and antifungals, the adjunct medications often used in HIV-positive patients. Hepatic insufficiency in seropositive patients on antiretrovirals may also increase the risk of QT interval prolongation. Conclusion Baseline and follow-up EKG in the susceptible population is suggested.

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Section: Resultsmentioning

confidence: 99%