Taraxacum officinale extract shows antitumor effects on pediatric cancer cells and enhance mistletoe therapy

Dandelion Root Extract Affects the Proliferation, Survival and Migration of Cervical Cancer Cell Lines

“…Analysis of wound healing showed the ability of R-EtOH to inhibit cell migration, showing greater effect in cancer cells. This effect has also been reported by other authors in different cancer cell lines treated with dandelion extracts [20,22,31]. HaCaT cells treated with R-EtOH were able to migrate more freely to the wound area than cancer cell lines, showing selectivity of R-EtOH to cancer cells.…”

“…Our ndings provide other authors' reports with additional information concerning the antitumor properties of T. o cinale, which turns this plant species into an important target in the search for new compounds that can be useful in cancer treatment [16,[20][21][22].…”

“…However, we did not nd signi cant differences between HeLa and HaCaT cells in this assay. R-EtOH showed a great cytotoxic effect, since [IC 50 ] values found were lower than reported in other studies [20][21][22]. This may be due to the nature of different cancer cell lines or to the fact that R-EtOH might contain a higher concentration of bioactive compounds, since the other reports refer to aqueous extracts.…”

“…Besides cell proliferation, migration is an important characteristic of tumor cells [20]. Thus, we performed wound healing assays to assess the impact of R-EtOH on cancer cell migration.…”

“…In addition, this extract would be cancer cell selective, as the same treatment is not detrimental to non-cancer cells [16][17][18][19]. Moreover, new studies have reported antitumor activity of T. o cinale in cell lines of pediatric cancer, colon cancer and gastric cancer [20][21][22].…”