Tardive Dyskinesia Predicts Prolactin Response to Buspirone Challenge in People With Schizophrenia

Abstract

Prolactin response to buspirone was evaluated in patients with schizophrenia, with and without tardive dyskinesia (TD). Prolactin response in patients with schizophrenia without TD was significantly decreased, compared to healthy comparison subjects (F = 6.36, df = 5, p < 0.0001). Furthermore, prolactin levels after administration of buspirone were not significantly increased from baseline. In contrast, there was no prolactin response difference between patients with schizophrenia and TD and healthy subjects. This finding suggests that decreased dopamine (D(2)) receptor sensitivity may result in lower risk of developing TD and may lead to a fuller understanding of the variable expression of D(2)-receptor mediated side effects.

Tardive Dyskinesia in Schizophrenia is Associated with Prolactin-Related Sexual Disturbances

“…Similarly, a recent report found high prolactin levels in a paranoid subgroup of never-medicated psychotic patients, suggestive of the existence of subtypes of psychotic illness associated with differences in dopaminergic tone (Segal et al, 2004). Another possible explanation may reside in differential D2 sensitivity in groups with and without TD (Shim et al, 2005). However, none of the above research findings provides a direct explanation for the association between PRSD and TD.…”

Tardive Dyskinesia Revisited-A Clinical Management Priority Perspective: A Voyage into High Dose Buspirone Part B

“…Therefore, respectfully, it should be the drug of choice in TD management at this stage, despite the lack of large amounts of data at this point. And that treatment has a consistent basis for its management based on dopamine partial agonism and not specifically hitting Dopamine 2/3 receptors as far as is known [285].…”

An epidemiological approach to elucidate dopaminergic mechanisms in tardive dyskinesia in schizophrenia

“…Similarly, a recent report found high prolactin levels in a paranoid subgroup of never-medicated psychotic patients, suggestive of the existence of subtypes of psychotic illness associated with differences in dopaminergic tone (Segal, Avital et al 2004). Another possible explanation may reside in differential D2 sensitivity in groups with and without TD (Shim, Kim et al 2005). However, none of the above research findings provides a direct explanation for the association between PRSD and TD.…”