Target modality determines eye-head coordination in nonhuman primates: implications for gaze control

Populin, Luis C.; Rajala, Abigail Z.

doi:10.1152/jn.00331.2011

Cited by 8 publications

(11 citation statements)

References 97 publications

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“…Shifts in eye position were larger for SC than LB; however, gaze-dependent reaching errors tend to saturate beyond 10°gaze relative to target (Bock, 1986;Henriques et al, 1998). The sighted individuals continued to maintain their eyes eccentrically with respect to the head; this likely reflects the natural contribution of the eyes and head seen for volitional large gaze shifts (Goossens and Van Opstal, 1997;Phillips et al, 1999;Populin and Rajala, 2011 Figure 2. A, Head traces (dashed lines) for all participants (n ϭ 12) of the three groups and eye traces (full lines) for the congenitally blind group (left, n ϭ 8), the late blind group with real eyes (middle, n ϭ 7), and the sighted control group (right, n ϭ 12) during the main experiment.…”

Section: Head and Eye Movementsmentioning

confidence: 92%

Spatial Updating Depends on Gaze Direction Even after Loss of Vision

Reuschel¹,

Rösler²,

Henriques³

et al. 2012

J. Neurosci.

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Direction of gaze (eye angle ϩ head angle) has been shown to be important for representing space for action, implying a crucial role of vision for spatial updating. However, blind people have no access to vision yet are able to perform goal-directed actions successfully. Here, we investigated the role of visual experience for localizing and updating targets as a function of intervening gaze shifts in humans. People who differed in visual experience (late blind, congenitally blind, or sighted) were briefly presented with a proprioceptive reach target while facing it. Before they reached to the target's remembered location, they turned their head toward an eccentric direction that also induced corresponding eye movements in sighted and late blind individuals. We found that reaching errors varied systematically as a function of shift in gaze direction only in participants with early visual experience (sighted and late blind). In the late blind, this effect was solely present in people with moveable eyes but not in people with at least one glass eye. Our results suggest that the effect of gaze shifts on spatial updating develops on the basis of visual experience early in life and remains even after loss of vision as long as feedback from the eyes and head is available.

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Section: Head and Eye Movementsmentioning

confidence: 92%

Spatial Updating Depends on Gaze Direction Even after Loss of Vision

Reuschel¹,

Rösler²,

Henriques³

et al. 2012

J. Neurosci.

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“…The most important parameters in investigating the neuronal basis of a specific behavior are, (1) establishing behavioral readouts with reproducibility over hundreds of trials, (2) recording the behavioral readouts with the temporal resolution of neural events. To facilitate the recording of neural events from an actively behaving animal on a single cell basis or population basis (reviewed in [16]), the best strategy is to keep the animals head-restrained [10], [17], [18]. But whether behavioral readouts from a head-restrained animal can be compared with that of a freely moving animal still remains unanswered.…”

Section: Introductionmentioning

confidence: 99%

Similar Odor Discrimination Behavior in Head-Restrained and Freely Moving Mice

et al. 2012

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A major challenge in neuroscience is relating neuronal activity to animal behavior. In olfaction limited techniques are available for these correlation studies in freely moving animals. To solve this problem, we developed an olfactory behavioral assay in head-restrained mice where we can monitor behavioral responses with high temporal precision. Mice were trained on a go/no-go operant conditioning paradigm to discriminate simple monomolecular odorants, as well as complex odorants such as binary mixtures of monomolecular odorants or natural odorants. Mice learned to discriminate both simple and complex odors in a few hundred trials with high accuracy. We then compared the discrimination performance of head-restrained mice to the performance observed in freely moving mice. Discrimination accuracies were comparable in both behavioral paradigms. In addition, discrimination times were measured while the animals performed well. In both tasks, mice discriminated simple odors in a few hundred milliseconds and took additional time to discriminate the complex mixtures. In conclusion, mice showed similar and efficient discrimination behavior while head-restrained compared with freely moving mice. Therefore, the head-restrained paradigm offers a relevant approach to monitor neuronal activity while animals are actively engaged in olfactory discrimination behaviors.

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“…This difference arises largely from the absence of a pre-saccadic attempted head movement during touch-evoked gaze shifts. This differential pairing of head and eye movements is reminiscent of reports in primates and cats that the relative contributions of head and eye movements vary for gaze shifts evoked by different sensory modalities (Goldring et al, 1996; Populin, 2006; Populin and Rajala, 2011; Populin et al, 2004a; Ruhland et al, 2013; Tollin et al, 2005). However, in those species, vision typically elicits gaze shifts dominated by saccades while hearing typically evokes gaze shifts entailing larger contributions from head movements.…”

Section: Discussionmentioning

confidence: 64%

“…Natural environments are complex and dynamic, and animals frequently redirect their gaze to scrutinize salient sensory stimuli. Gaze shifts employ head and eye movement coupling strategies that depend on context and can vary between species (Goldring et al, 1996; Land, 2019; Land and Nilsson, 2012; Populin, 2006; Populin and Rajala, 2011; Populin et al, 2004a; Ruhland et al, 2013; Tollin et al, 2005). Mice are an increasingly important model organism in vision research, yet the strategies they use to shift their gaze remain incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

A new type of mouse gaze shift is led by directed saccades

Zahler¹,

Taylor²,

Wong³

et al. 2021

Preprint

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Humans read text, recognize faces, and process emotions using targeted saccadic eye movements. In the textbook model, this innate ability to make targeted saccades evolved in species with foveae or similar high-acuity retinal specializations that enable scrutiny of salient stimuli. According to the model, saccades made by species without retinal specializations (such as mice) are never targeted and serve only to reset the eyes after gaze-stabilizing movements. Here we show that mice innately make touch-evoked targeted saccades. Optogenetic manipulations revealed the neural circuit mechanisms underlying targeted saccades are conserved. Saccade probability is a U-shaped function of current eye position relative to the target, mirroring the simulated relationship between an object's location within the visual field and the probability its next movement carries it out of view. Thus, a cardinal sophistication of our visual system may have had an unexpectedly early origin as an innate behavior that keeps stimuli in view.

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Target modality determines eye-head coordination in nonhuman primates: implications for gaze control

Abstract: Populin LC, Rajala AZ. Target modality determines eye-head coordination in nonhuman primates: implications for gaze control.

Cited by 8 publications

References 97 publications

Spatial Updating Depends on Gaze Direction Even after Loss of Vision

Spatial Updating Depends on Gaze Direction Even after Loss of Vision

Similar Odor Discrimination Behavior in Head-Restrained and Freely Moving Mice

A new type of mouse gaze shift is led by directed saccades

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