Targeted broadband ultraviolet B phototherapy improves disorders characterized by increased dermal matrix

Abstract

is that the association signal we detected was due to the presence of regulatory rather than coding SNPs, as indeed is the case for many autoimmune diseases. 7 The data generated by the HapMap Consortium are consistent with this hypothesis, as they show that variants identified in our previous association study are in strong linkage disequilibrium with several SNPs mapping to the DSG3 promoter. The notion that alleles affecting DSG3 regulation may be pathogenic is also in agreement with results obtained in animal models, demonstrating that altered DSG3 expression can affect epidermal differentiation 8 and keratinocyte cohesion. 9 In this context, a functional and genetic characterization of DSG3 regulatory elements is now required and holds the promise to identify novel sequence variants affecting gene expression and disease susceptibility. AcknowledgmentsWe thank the PV network as well as all the patients who participated in this study.

NB-UVB phototherapy for generalized granuloma annulare

“…Although UVB phototherapy is widely used in dermatology, we found only two case reports and one case series examining its efficacy in GA .…”

Granuloma Annulare

“…Improvement in 5 patients treated with 16 weeks of thrice-weekly therapy with broadband UV-B was demonstrated by Do and colleagues. 102 The use of various forms of UV-A has also been efficacious. Small studies using UV-A1 have shown improvement in lesions; however, relapses were common after discontinuation of therapy.…”

“…Immunosuppression with methotrexate, cyclosporine, and TNF-a inhibitors can be considered in patients with severe disease that has been recalcitrant to other therapies. 28,[87][88][89][90][91][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][114][115][116][117][118][119][120][121][122][123][124]126,127,129,130,[132][133][134][140][141][142][144][145][146][147][148]150,…”

“…Reported skin-directed and systemic treatments of granuloma annulare BB-UVB102 3  Per wk  16 wk Good or excellent response C UV-A1[103][104][105] High dose and medium dose Improvement but with relapse…”

Improving acne keloidalis nuchae with targeted ultraviolet B treatment: a prospective, randomized, split‐scalp comparison study

“…Ultraviolet (UV) irradiation induces the production of several members of the matrix metalloproteinase (MMP) family, which degrade collagen fibrils and other components of the dermal extracellular matrix (ECM). The subfamily of collagenases including MMP‐1 (interstitial collagenase) degrades native fibrillar interstitial collagens, whereas gelatinases including MMP‐9 (gelatinase B) efficiently digest degraded collagen, thus complementing collagenases in the degradation of fibrillar collagen . In addition to turnover and degradation of the ECM, MMPs also regulate various inflammatory, repair and immune processes.…”