2004
DOI: 10.1161/01.cir.0000138191.11580.e3
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Targeted Cell Delivery Into Infarcted Rat Hearts by Retrograde Intracoronary Infusion: Distribution, Dynamics, and Influence on Cardiac Function

Abstract: Background-Intracoronary infusion for cell transplantation has potential advantages in disseminating cells globally into the myocardium with less injury over direct intramuscular injection. Arterial route, however, has a risk of coronary embolism and a limitation in cell delivery into ischemic or infarcted areas. We assessed the efficiency of retrograde intracoronary cell implantation into infarcted hearts using a novel rat model. Methods and Results-After left coronary artery ligation in rat, a catheter was i… Show more

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Cited by 55 publications
(62 citation statements)
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“…9 The perfusion area by this infusion method has been shown to fully encompass the whole ischemic area after LCA ligation. 9 Through a 24-gauge catheter, which was inserted into the left cardiac vein, the appropriate antibody suspended in 0.5 mL phosphate-buffered saline was injected into the vein over a period of 5 seconds. Then, 25 seconds after the end of injection, occlusion of LCA was released for reperfusion.…”
Section: Retrograde Intracoronary Infusion Of Antibodiesmentioning
confidence: 93%
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“…9 The perfusion area by this infusion method has been shown to fully encompass the whole ischemic area after LCA ligation. 9 Through a 24-gauge catheter, which was inserted into the left cardiac vein, the appropriate antibody suspended in 0.5 mL phosphate-buffered saline was injected into the vein over a period of 5 seconds. Then, 25 seconds after the end of injection, occlusion of LCA was released for reperfusion.…”
Section: Retrograde Intracoronary Infusion Of Antibodiesmentioning
confidence: 93%
“…Male Lewis rats (300 to 350 grams; Charles River, UK) underwent left thoracotomy under anesthesia with sodium pentobarbital (40 mg/kg, intraperitoneal) and mechanical ventilation. 9 The left coronary artery (LCA) was occluded for 30 minutes and then released for reperfusion. 10 …”
Section: Induction Of Myocardial Ischemia-reperfusion Injurymentioning
confidence: 99%
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“…Em nosso estudo, utilizamos a técnica descrita por Rangappa et al 17 e Suzuki et al 18 e reproduzida por Yokoyama et al 19 , na qual o cateter transpassa o seio coronário até a veia interventricular anterior, sendo posicionado na mesma região em que foi realizada a infusão coronária arterial. Isso é possível pela disposição das veias, paralelas às artérias na superfície do coração.…”
Section: Vias De Infusão Para Entrega Celular Em Tecido Cardíacounclassified
“…Mesenchymal stem cells are being studied for their ability to deliver anti-cancer drugs to tumors due to their natural tumor-tropic properties 2,3 . Cardiac stem cells have been delivered to the heart as a possible treatment for myocardial infarction 4,5 . Vascular stents have been developed with CD34 antibodies to capture circulating progenitor cells 6 .…”
Section: Introductionmentioning
confidence: 99%