Targeted cell imaging properties of a deep red luminescent iridium(<scp>iii</scp>) complex conjugated with a c-Myc signal peptide

Day, Adam H.; Ubler, Martin H.; Best, Hannah; Lloyd-Evans, Emyr; Mart, Robert J.; Fallis, Ian A.; Allemann, Rudolf Konrad; Al-Wattar, Eman A. H.; Keymer, Nathaniel I.; Buurma, Niklaas J.; Pope, Simon J. A.

doi:10.1039/c9sc05568a

Cited by 43 publications

(33 citation statements)

References 65 publications

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“…(i) Preparation of the chloro-bridge dimer [Ir(ppy)2Cl]2 (ppy = cyclometalated 2-phenylpyridine) from IrCl3.3H2O [65]; (ii) Bridge splitting reaction with the deprotonated curcumin or tetrahydrocurcumin [53].…”

Section: Resultsmentioning

confidence: 99%

Cyclometalated Ir(III) Complexes with Curcuminoid Ligands as Active Second-Order NLO Chromophores and Building Blocks for SHG Polymeric Films

et al. 2020

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The second-order nonlinear optical (NLO) properties of iridium(III) complexes having two cyclometalated 2-phenylpyridines and curcumin or tetrahydrocurcumin as ancillary ligand have been investigated both in solution and as guest in a polymeric organic matrix. In solution, these complexes are characterized by a significant second-order NLO response, as determined by the Electric Field Induced Second Harmonic (EFISH) technique, like the related complex with acetylacetonate. Whereas the low second-harmonic generation response of a composite film of [Ir(2-phenylpyridine)2(acetylacetonate)] in polymethyl methacrylate was not stable and fell down to zero upon turning off the electric field. A good and stable response was obtained with a film based on the iridium(III) complex bearing two cyclometalated 2-phenylpyridines and curcumin.

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Section: Resultsmentioning

confidence: 99%

Cyclometalated Ir(III) Complexes with Curcuminoid Ligands as Active Second-Order NLO Chromophores and Building Blocks for SHG Polymeric Films

et al. 2020

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“…The phosphorescent emission at 405 nm for the four benzimidazole-containing iridium(III) complex compounds ( Figure 5 ) [ 49 , 50 , 51 ] may be due to an electron transition between 1 MLCT (singlet ligand-to-ligand charge transfer) and 3 MLCT in the ligands. The relationship between the number of aromatic rings with nitrogen atoms and a greater shift in emission was demonstrated.…”

Section: Structure and Physicochemical Characteristics Of Coordination Complexes As Photosensitizers For Photodynamic Anticancer Therapymentioning

confidence: 99%

Coordination Complexes as a New Generation Photosensitizer for Photodynamic Anticancer Therapy

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et al. 2021

IJMS

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Photodynamic therapy (PDT) has become an alternative to standard cancer treatment methods such as surgery, chemotherapy and radiotherapy. The uniqueness of this method relies on the possibility of using various photosensitizers (PS) that absorb and convert light emission in radical oxygen-derived species (ROS). They can be present alone or in the presence of other compounds such as metal organic frameworks (MOFs), non-tubules or polymers. The interaction between DNA and metal-based complexes plays a key role in the development of new anti-cancer drugs. The use of coordination compounds in PDT has a significant impact on the amount ROS generated, quantum emission efficiency (Φem) and phototoxic index (PI). In this review, we will attempt to systematically review the recent literature and analyze the coordination complexes used as PS in PDT. Finally, we compared the anticancer activities of individual coordination complexes and discuss future perspectives. So far, only a few articles link so many transition metal ion coordination complexes of varying degrees of oxidation, which is why this review is needed by the scientific community to further expand this field worldwide. Additionally, it serves as a convenient collection of important, up-to-date information.

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“…After being internalized by the cell, some luminescent labels accumulate in a specific organelle due to physical-chemical interactions [ 37 , 38 , 39 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ]. One of the techniques used to determine in which organelle the luminescent label accumulates is the fluorescence co-localization experiment.…”

Section: Luminescence Imagingmentioning

confidence: 99%

“…The reader is referred to the literature for more details about the fluorescence microscope components [14]. After being internalized by the cell, some luminescent labels accumulate in a specific organelle due to physical-chemical interactions [37][38][39][95][96][97][98][99][100][101][102][103][104][105][106][107]. One of the techniques used to determine in which organelle the luminescent label accumulates is the fluorescence co-localization experiment.…”

Section: Luminescence Imagingmentioning

confidence: 99%

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

et al. 2020

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The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application in luminescence imaging of biological systems; the afterglow emission grants background-free luminescence imaging, there is no need for continuous excitation to avoid tissue and cell damage due to the continuous light exposure, and they also circumvent the depth penetration issue caused by excitation in the UV-Vis. This review aims to provide a background in luminescence imaging of biological systems, persistent luminescence, and synthetic methods for obtaining persistent luminescent materials, and discuss selected examples of recent literature on the applications of persistent luminescent materials in luminescence imaging of biological systems and photodynamic therapy. Finally, the challenges and future directions, pointing to the development of compounds capable of executing multiple functions and light in regions where tissues and cells have low absorption, will be discussed.

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Targeted cell imaging properties of a deep red luminescent iridium(iii) complex conjugated with a c-Myc signal peptide

Abstract: Visualising a c-Myc nuclear localisation signal peptide using an organometallic complex.

Cited by 43 publications

References 65 publications

Cyclometalated Ir(III) Complexes with Curcuminoid Ligands as Active Second-Order NLO Chromophores and Building Blocks for SHG Polymeric Films

Cyclometalated Ir(III) Complexes with Curcuminoid Ligands as Active Second-Order NLO Chromophores and Building Blocks for SHG Polymeric Films

Coordination Complexes as a New Generation Photosensitizer for Photodynamic Anticancer Therapy

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

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