Targeted Delivery of Cabazitaxel Using Cyclic Cell-Penetrating Peptide and Biomarkers of Extracellular Matrix for Prostate and Breast Cancer Therapy

Park, Shang Eun; El-Sayed, Naglaa Salem; Shamloo, Kiumars; Lohan, Sandeep; Kumar, Sumit; Sajid, Muhammad Imran; Tiwari, Rakesh

doi:10.1021/acs.bioconjchem.1c00319

Cited by 18 publications

(13 citation statements)

References 55 publications

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“…Active targeting of small molecule drugs is essential to improving the efficacy of antitumor therapy. Park et al ( 2021 ) synthesized cyclic CPP conjugated CBT (cCPP-CBT) via an ester bond that can be hydrolyzed by esterase. They also conjugated targeting peptides with cCPP-CBT (TP-cCPP-CBT) via a disulfide bond that can be labile under a reductive environment.…”

Section: Application Of the Cpp-based Delivery Systemmentioning

confidence: 99%

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

2023

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Biological cell membranes are a natural barrier for living cells. In the last few decades, the cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic agents. To increase the drug efficacy of these agents, additional mediators have been considered. Cell-penetrating peptides (CPPs), a series of oligopeptides composed of mostly hydrophobic and/or positively charged side chains, can increase the interaction with the cell membrane. CPP-based delivery platforms have shown great potential for the efficient and direct cytosol delivery of various cargos, including genes, proteins, and small molecule drugs. Bypassing endocytosis allows the CPP-based delivery systems greater defense against the degradation of protein-based drugs than other drug delivery systems. However, the delivery of CPPs exhibits intrinsically non-specific targeting, which limits their medical applications. To endow CPPs with specific targeting ability, the conjugation of pH-sensitive, enzyme-specific cleavable, and multiple targeting ligands has been reported. Optimization of the length and sequence of CPPs is still needed for various drugs of different sizes and surface charges. Toxicity issues in CPP-based delivery systems should be addressed carefully before clinical use.

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Section: Application Of the Cpp-based Delivery Systemmentioning

confidence: 99%

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

2023

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“…SP90-C revealed well targeted delivery function for anticancer drugs. Park et al (2021) synthesized anticancer drugs targeting the weak acidic condition of the breast tumor by conjugating cyclic CPP (cCPP, CWRWRKWRWR) with a targeting peptide (TP1 or TP2) and anticancer drug cabazitaxel (CBT). TP1-cCPP-CBT revealed antiproliferative activity on MDA-MB-231 and MCF-7 cells.…”

Section: Peptides For Anticancer Drug Vectorsmentioning

confidence: 99%

Recent advances in peptide-based therapeutic strategies for breast cancer treatment

Duns

Dessie

et al. 2023

Front. Pharmacol.

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Breast cancer is the leading cause of cancer-related fatalities in female worldwide. Effective therapies with low side effects for breast cancer treatment and prevention are, accordingly, urgently required. Targeting anticancer materials, breast cancer vaccines and anticancer drugs have been studied for many years to decrease side effects, prevent breast cancer and suppress tumors, respectively. There are abundant evidences to demonstrate that peptide-based therapeutic strategies, coupling of good safety and adaptive functionalities are promising for breast cancer therapy. In recent years, peptide-based vectors have been paid attention in targeting breast cancer due to their specific binding to corresponding receptors overexpressed in cell. To overcome the low internalization, cell penetrating peptides (CPPs) could be selected to increase the penetration due to the electrostatic and hydrophobic interactions between CPPs and cell membranes. Peptide-based vaccines are at the forefront of medical development and presently, 13 types of main peptide vaccines for breast cancer are being studied on phase III, phase II, phase I/II and phase I clinical trials. In addition, peptide-based vaccines including delivery vectors and adjuvants have been implemented. Many peptides have recently been used in clinical treatments for breast cancer. These peptides show different anticancer mechanisms and some novel peptides could reverse the resistance of breast cancer to susceptibility. In this review, we will focus on current studies of peptide-based targeting vectors, CPPs, peptide-based vaccines and anticancer peptides for breast cancer therapy and prevention.

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“…The conjugates showed less toxicity to normal human embryonic kidney (HEK-293) cells compared to free CBT while displaying approximately three- to four-fold higher antiproliferative activity on cancer cell lines, compared to the free CBT analog. Although the increased drug delivery can be attributed to the presence of CPPs, the widespread use of these types of PDCs is still limited due to their low cellular specificity [ 91 ].…”

Section: Categories Of Drug Conjugatesmentioning

confidence: 99%

Research Progress of Conjugated Nanomedicine for Cancer Treatment

Zhao

Chen

Hong³

et al. 2022

Pharmaceutics

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The conventional cancer therapeutic modalities include surgery, chemotherapy and radiotherapy. Although immunotherapy and targeted therapy are also widely used in cancer treatment, chemotherapy remains the cornerstone of tumor treatment. With the rapid development of nanotechnology, nanomedicine is believed to be an emerging field to further improve the efficacy of chemotherapy. Until now, there are more than 17 kinds of nanomedicine for cancer therapy approved globally. Thereinto, conjugated nanomedicine, as an important type of nanomedicine, can not only possess the targeted delivery of chemotherapeutics with great precision but also achieve controlled drug release to avoid adverse effects. Meanwhile, conjugated nanomedicine provides the platform for combining several different therapeutic approaches (chemotherapy, photothermal therapy, photodynamic therapy, thermodynamic therapy, immunotherapy, etc.) with the purpose of achieving synergistic effects during cancer treatment. Therefore, this review focuses on conjugated nanomedicine and its various applications in synergistic chemotherapy. Additionally, the further perspectives and challenges of the conjugated nanomedicine are also addressed, which clarifies the design direction of a new generation of conjugated nanomedicine and facilitates the translation of them from the bench to the bedside.

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Targeted Delivery of Cabazitaxel Using Cyclic Cell-Penetrating Peptide and Biomarkers of Extracellular Matrix for Prostate and Breast Cancer Therapy

Cited by 18 publications

References 55 publications

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

Recent advances in peptide-based therapeutic strategies for breast cancer treatment

Research Progress of Conjugated Nanomedicine for Cancer Treatment

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