Targeted Delivery of Exosomes Armed with Anti-Cancer Therapeutics

Choi, Hojun; Yim, Hwayoung; Park, Cheolhyoung; Ahn, So-Hee; Ahn, Yura; Lee, Areum; Yang, Heekyoung; Choi, Chulhee

doi:10.3390/membranes12010085

Cited by 25 publications

(18 citation statements)

References 119 publications

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“…This scientific evidence suggests that exosomes overcome nanoparticles based on multiple membrane cross-constraint. This attribute of the exosome makes it a more efficient drug delivery tool . From this we can conclude that exosomes can not only transport the drugs but also increase their half-life, reduce toxicity, and even overcome various barriers.…”

Section: Passive Loading Approachmentioning

confidence: 76%

Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

Kar

Dhar

Mukherjee

et al. 2023

ACS Biomater. Sci. Eng.

104

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Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. The main activity of exosomes is cellular communication. In cancer, exosomes play an important rolefrom two distinct perspectives, one related to carcinogenesis and the other as theragnostic and drug delivery tools. The outer phospholipid membrane of Exosome improves drug targeting efficiency. . Some of the vital features of exosomes such as biocompatibility, low toxicity, and low immunogenicity make it a more exciting drug delivery system. Exosome-based drug delivery is a new innovative approach to cancer treatment. Exosome-associated biomarker analysis heralded a new era of cancer diagnostics in a more specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with cancer and exosome-related cancer biomarkers, drug loading methods, exosome-based biomolecule delivery, advances and limitations of exosome-based drug delivery, and exosome-based drug delivery in clinical settings studies. The exosome-based understanding of cancer will change the diagnostic and therapeutic approach in the future.

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Section: Passive Loading Approachmentioning

confidence: 76%

Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

Kar

Dhar

Mukherjee

et al. 2023

ACS Biomater. Sci. Eng.

104

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show abstract

“…For example, Castillo et al carried out the surfaceome profiling of pancreatic ductal adenocarcinoma (PDAC) exosomes by proteomic approach [ 112 ]. On the other side, the study of EVs surfaceome might provide powerful tools for diagnostic and therapeutic actions, such as antibody mediated therapy, as well as for drug delivery strategies by engineering EVs with specific target-cell recognition protein on their surface [ 113 , 114 ]. Summary data are reported in Table A1 .…”

Section: Extracellular Vesicle As Resourceful Biological Systemsmentioning

confidence: 99%

Multi-Omics Integrative Approach of Extracellular Vesicles: A Future Challenging Milestone

et al. 2022

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In the era of multi-omic sciences, dogma on singular cause-effect in physio-pathological processes is overcome and system biology approaches have been providing new perspectives to see through. In this context, extracellular vesicles (EVs) are offering a new level of complexity, given their role in cellular communication and their activity as mediators of specific signals to target cells or tissues. Indeed, their heterogeneity in terms of content, function, origin and potentiality contribute to the cross-interaction of almost every molecular process occurring in a complex system. Such features make EVs proper biological systems being, therefore, optimal targets of omic sciences. Currently, most studies focus on dissecting EVs content in order to either characterize it or to explore its role in various pathogenic processes at transcriptomic, proteomic, metabolomic, lipidomic and genomic levels. Despite valuable results being provided by individual omic studies, the categorization of EVs biological data might represent a limit to be overcome. For this reason, a multi-omic integrative approach might contribute to explore EVs function, their tissue-specific origin and their potentiality. This review summarizes the state-of-the-art of EVs omic studies, addressing recent research on the integration of EVs multi-level biological data and challenging developments in EVs origin.

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“…For example, Castillo et al carried out the surfaceome profiling of pancreatic ductal adenocarcinoma (PDAC) exosomes by proteomic approach [103]. On the other side, the study of EVs surfaceome might provide powerful tools for diagnostic and therapeutic actions, such as antibody mediated therapy, as well as for drug delivery strategies by engineering EVs with specific target-cell recognition protein on their surface [104,105]. Summary data are reported in table 1.…”

Section: Surfaceomicsmentioning

confidence: 99%

Multi-Omics Integrative Approach of Extracellular Vesicles: A Future Challenging Milestone

Shaba¹,

Vantaggiato²,

Governini³

et al. 2022

Preprint

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In the era of multi-omic sciences, dogma on singular cause-effect in physio-pathological processes is overcome and system biology approaches have been providing new perspectives to see through. In this context, extracellular vesicles (EVs) are offering a new level of complexity, given their role in cellular communication and their activity as mediators of specific signals to target cells or tissues. Indeed, their heterogeneity in terms of content, function, origin and potentiality contribute to the cross-interaction of almost every molecular process occurring in a complex system. Such features make EVs proper biological systems being, therefore, optimal targets of omic sciences. Currently, most studies focus on dissecting EVs content in order to either characterize it or to explore its role in various pathogenic processes at transcriptomic, proteomic, metabolomic, lipidomic and genomic levels. Despite valuable results are being provided by individual omic studies, the categorization of EVs biological data might represent a limit to be overcome. For this reason, a multi-omic integrative approach might contribute to explore EVs function, their tissue-specific origin and their potentiality. This review summarizes the state-of-the-art of EVs omic studies, addressing recent research on the integration of EVs multi-level biological data and challenging developments in EVs origin.

show abstract

Targeted Delivery of Exosomes Armed with Anti-Cancer Therapeutics

Cited by 25 publications

References 119 publications

Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

Multi-Omics Integrative Approach of Extracellular Vesicles: A Future Challenging Milestone

Multi-Omics Integrative Approach of Extracellular Vesicles: A Future Challenging Milestone

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