Targeted drug delivery to magnetic implants for therapeutic applications

Yellen, Benjamin B.; Forbes, Z.G.; Halverson, Derek; Fridman, Greg; Barbee, Kenneth A.; Chorny, Michael; Levy, Robert J.; Friedman, Gary D.

doi:10.1016/j.jmmm.2005.01.083

Cited by 156 publications

(97 citation statements)

References 12 publications

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“…Thus, the average projection of m the moment in the direction of B total can be calculated from the Langevin function [6,8,22,23,24]…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Specifically it can be difficult using external magnets only to target areas deep within the body, without targeting the surface more strongly [6]. To overcome this problem several authors [7,8,9,10,11,12,13,14,15,16] have proposed implanting ferromagnetic materials such as wires, seeds and stents within the body. Of the various IA-MTD implants suggested by Ebner, Ritter and coworkers [9,10,11,12,13,14,15,16], we consider a magnetizable stent as the implant, with MDCPs containing magnetic single domain nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

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Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting

Cregg

Murphy

Mardinoğlu

et al. 2010

Journal of Magnetism and Magnetic Materials

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The implant assisted magnetic targeted drug delivery system of Avilés, Ebner and Ritter is considered both experimentally (in vitro) and theoretically. The results of a 2D mathematical model are compared with 3D experimental results for a magnetizable wire stent. In this experiment a ferromagnetic, coiled wire stent is implanted to aid collection of particles which consist of single domain magnetic nanoparticles (radius ≈ 10 nm). In order to model the agglomeration of particles known to occur in this system, the magnetic dipole-dipole and hy- A c c e p t e d m a n u s c r i p t PACS: 47.63.mh, 87.85.gf

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“…Thus, the average projection of m the moment in the direction of B total can be calculated from the Langevin function [6,8,22,23,24]…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting

Cregg

Murphy

Mardinoğlu

et al. 2010

Journal of Magnetism and Magnetic Materials

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“…These advanced materials are used in key applications such as drug/gene delivery, magnetic drug targeting, thermotherapies, stem cell targeting, and in diagnostic imaging (as contrast agents) [2][3][4][5][6]. The size and surface chemistry of MPs can be tailored for molecules with which they are 'functionalized', enabling the construction of multimodal particles that can mediate combinations of cellular applications, whilst retaining nanoscale dimensions [7].…”

Section: Introductionmentioning

confidence: 99%

Differences in Magnetic Particle Uptake by CNS Neuroglial Subclasses: Implications for Neural Tissue Engineering

et al. 2013

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Materials and Methods: MP uptake and processing were studied in rat OPCs and oligodendrocytes, using fluorescence and transmission electron microscopy, and results collated with previous data from microglia and astrocytes.Results: Significant intercellular differences were observed between glial subtypes, with microglia demonstrating the most rapid/extensive particle uptake, followed by astrocytes, with OPCs and oligodendrocytes showing significantly lower uptake. Ultrastructural analyses suggest that MPs are extensively degraded in microglia but are relatively stable in other cells. Conclusions:Our findings have implications for use of the MP platform in a range of neural tissue engineering applications such as transfection, cell labeling and direct CNS biomolecule delivery.

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“…Experimental results have demonstrated that capturing superparamagnetic beads of both micrometer and submicrometer diameter at reasonably high concentrations is possible in flow conditions consistent with the dimensions and flow velocity occurring in the coronary artery in the human body. The same experiments performed with non-magnetic mesh resulted in no significant capture, indicating that the implant is responsible for providing the necessary magnetic field gradients and forces to capture the injected beads (Yellen et al, 2005).…”

Section: Magnetic Targetingmentioning

confidence: 83%

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Bucak¹,

Yavuztürk²,

Sezer³

2012

Recent Advances in Novel Drug Carrier Systems

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Targeted drug delivery to magnetic implants for therapeutic applications

Cited by 156 publications

References 12 publications

Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting

Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting

Differences in Magnetic Particle Uptake by CNS Neuroglial Subclasses: Implications for Neural Tissue Engineering

Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

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