Targeted exome sequencing for the identification of a protective variant against Internet gaming disorder at rs2229910 of neurotrophic tyrosine kinase receptor, type 3 (NTRK3): A pilot study

Kim, Jeong-Yu; Jeong, Jo-Eun; Rhee, Je-Keun; Cho, Hyun; Chun, Ji Won; Kim, Tae-Min; Choi, Sam‐Wook; Choi, Jung Seok; Kim, Daijin

doi:10.1556/2006.5.2016.077

Cited by 18 publications

(12 citation statements)

References 43 publications

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“…However, studies determining the genetic factors of GD for a designed intervention are scarce. Until now, only two studies have demonstrated associations of the C allele of rs1044396 in the nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) [ 2 ] and rs2229910 of NTRK3 [ 3 ] with IGD. Further research to evaluate the associations between polymorphisms and their associated factors is necessary for intervention design.…”

Section: Introductionmentioning

confidence: 99%

Roles of Hostility and Depression in the Association between the MAOA Gene Polymorphism and Internet Gaming Disorder

Yen

Chou

Lin

et al. 2021

IJERPH

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The metabolism of bioamine in the central nervous system contributes to the development of addiction. We examined the roles of hostility and depression in the association between internet gaming disorder (IGD) and monoamine oxidase-A (MAOA) EcoRV polymorphism (rs1137070). A total of 69 adults with IGD and 138 without IGD were recruited through diagnostic interviewing. We evaluated participants for rs1137070, depression, and hostility. The participants with the TT genotype of rs1137070 had a higher odds ratio of 2.52 (1.37–4.64) for IGD compared with the C carriers. Expressive hostility behavior and hostility cognition mediated the association between rs1137070 and IGD. Indicating lower MAOA activity, the TT genotype predicted IGD and higher expressive hostility behavior and hostility cognition. Expressive hostility behavior and hostility cognition may underline the association between rs1137070 and IGD. Assessment of and intervention for hostility behavior and cognition should be provided to attenuate the risk of IGD, particularly in those with the TT genotype. Further brain imaging or neurobiological studies are required to elucidate the possible mechanism underlying the association between MAOA activity and IGD.

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Section: Introductionmentioning

confidence: 99%

Roles of Hostility and Depression in the Association between the MAOA Gene Polymorphism and Internet Gaming Disorder

Yen

Chou

Lin

et al. 2021

IJERPH

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“…In terms of genetic features, IGD associations with personality traits, such as sensation-seeking [ 12 ], impulsivity [ 13 ], and self-control [ 14 ], have been identified. In addition, several association studies showed that the Taq1A1 allele of the dopamine receptor gene ( DRD2 ) [ 15 ], the methionine variant of dopamine degradation enzyme gene ( COMT ) [ 15 ], short allelic variants of the serotonin transporter gene ( 5-HTTLPR ) [ 16 ], and polymorphisms of the nicotinic acetylcholine receptor gene ( CHRNA4 ) [ 17 ] and neurotrophic tyrosine kinase type 3 receptor gene ( NTRK3 ) [ 18 ] were associated with PIU. These personality traits and polymorphisms have also been shown to influence diverse substance addictions [ 19 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

The association between the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults

et al. 2017

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The primary aim of this study was to investigate the genetic predisposition of Internet gaming disorder (IGD), and the secondary aim was to compare the results to those of alcohol dependence (AD). Two independent case-control studies were conducted. A total of 30 male participants with IGD, diagnosed according to the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, and 30 sex-matched controls participated in study 1. We designed targeted exome sequencing (TES) to test for 72 candidate genes that have been implicated in the pathogenesis of addiction. The genes included seven neurotransmitter (dopamine, serotonin, glutamate, r-aminobutyric acid (GABA), norepinephrine, acetylcholine, and opioid) system genes. A total of 31 male in-patients with AD and 29 normal male controls (NC) were enrolled in study 2. The same 72 genes included in study 1 and ten additional genes related to alcohol-metabolic enzyme were selected as the target genes, and we identified the genetic variants using the same method (TES). The IGD group had a lower frequency of the allele of rs1044396 in the nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4), and this variant represents a protective allele against IGD. However, we did not find a significant difference in the polymorphisms of the 72 genes that encode neurotransmitter systems between the AD and NC groups. This study demonstrated that rs1044396 of CHRNA4 was significantly associated with IGD.

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“…Tras el análisis de los estudios se identifican seis factores que pueden influir en el IGD, como son los factores ambientales (Hong et al, 2019), sociodemográficos (Männikkö et al, 2018), variantes genéticas (Kim et al, 2016), psicosociales, las relaciones familiares y el perfil de los menores diagnosticados con IGD.…”

Section: Factores Asociados Al Igdunclassified

Videojuegos, salud, convivencia y adicción. ¿Qué dice la evidencia científica?

Gómez

Rial-Boubeta

Suelves

et al. 2022

psye

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El uso de videojuegos provoca discursos encontrados respecto a sus beneficios o perjuicios sobre la salud mental, la adicción y la convivencia. Actualmente, el Trastorno por Uso de Videojuegos aparece en las clasificaciones diagnósticas de la OMS (CIE-11) y de la APA (Sección III del DSM-5), lo que muestra el alcance de esta cuestión. Este trabajo tiene como objetivo analizar la literatura científica de 2016 a 2020 desde una doble vertiente, para poner de relieve la tendencia de los estudios y arrojar luz sobre los efectos del uso de videojuegos en menores. Se realizó un estudio bibliométrico y de contenido utilizando la base de datos Scopus, identificando 1,519 referencias, de las cuales 151 se emplearon para el estudio bibliométrico y las 98 disponibles en acceso abierto para el análisis de contenido. Los resultados muestran que, en general, no se puede afirmar que tengan efectos negativos per se, aunque los estudios coinciden en que pueden dar lugar a un uso problemático, por lo que ha de supervisarse de manera oportuna por los adultos significativos. Igualmente, existen trabajos que muestran los beneficios de la introducción de los videojuegos como herramienta para el aprendizaje y el desarrollo. Se concluye la polarización de estudios, señalando tanto efectos positivos como negativos de los videojuegos.

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Targeted exome sequencing for the identification of a protective variant against Internet gaming disorder at rs2229910 of neurotrophic tyrosine kinase receptor, type 3 (NTRK3): A pilot study

Cited by 18 publications

References 43 publications

Roles of Hostility and Depression in the Association between the MAOA Gene Polymorphism and Internet Gaming Disorder

Roles of Hostility and Depression in the Association between the MAOA Gene Polymorphism and Internet Gaming Disorder

The association between the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults

Videojuegos, salud, convivencia y adicción. ¿Qué dice la evidencia científica?

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