Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease

Xiong, Shiyun; Luo, Jingshan; Wang, Qun; Li, Zhongjun; Li, Juntong; Li, Qiao; Gao, Liqian; Fang, Shuhuan; Li, Yunyong; Pan, Huafeng; Wang, Hong; Zhang, Yongbin; Wang, Qi; Chen, Xiao‐Jia; Chen, Tongkai

doi:10.1039/d0bm01765e

Cited by 60 publications

(58 citation statements)

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“…Graphene is an important carbon nanomaterial with unique physical and chemical properties, such as a colossal surface area, robust thermal and electrical conductivity, and good mechanical strength, which make it a chosen material for nanoelectronics [ 1 ], biomedicine [ 2 ], mechanical engineering [ 3 ], and environmental governance [ 4 ]. It is estimated that at least 1.3 billion dollars will be injected to develop new applications for graphene from 2014 to 2024 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of graphene on morphology, microstructure and transcriptomic profiling of Pinus tabuliformis Carr. roots

et al. 2021

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Graphene has shown great potential for improving growth of many plants, but its effect on woody plants remains essentially unstudied. In this work, Pinus tabuliformis Carr. bare-rooted seedlings grown outdoors in pots were irrigated with a graphene solution over a concentration range of 0–50 mg/L for six months. Graphene was found to stimulate root growth, with a maximal effect at 25 mg/L. We then investigated root microstructure and carried out transcript profiling of root materials treated with 0 and 25 mg/L graphene. Graphene treatment resulted in plasma-wall separation and destruction of membrane integrity in root cells. More than 50 thousand of differentially expressed genes (DEGs) were obtained by RNA sequencing, among which 6477 could be annotated using other plant databases. The GO enrichment analysis and KEGG pathway analysis of the annotated DEGs indicated that abiotic stress responses, which resemble salt stress, were induced by graphene treatment in roots, while responses to biotic stimuli were inhibited. Numerous metabolic processes and hormone signal transduction pathways were altered by the treatment. The growth promotion effects of graphene may be mediated by encouraging proline synthesis, and suppression of the expression of the auxin response gene SMALL AUXIN UP-REGULATED RNA 41 (SAUR41), PYL genes which encode ABA receptors, and GSK3 homologs.

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Section: Introductionmentioning

confidence: 99%

Effects of graphene on morphology, microstructure and transcriptomic profiling of Pinus tabuliformis Carr. roots

et al. 2021

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Section: Nanocarriers Improve Cns Bioavailability Of Plant Compounds With Antioxidative and Neuroprotective Activitymentioning

confidence: 99%

“…Interestingly, nanosystems associated with ligands as transferrin and lactoferrin have been used to target specific receptors expressed in the BBB and to exploit the process of receptor-mediated endocytosis to reach the brain [195][196][197][198]. These nanosystems provide significantly higher brain bioavailability and neuroprotective effects of plant chemicals in ND brains [197][198][199] (Table 3, Sections 5.3 and 8.1). Alternatively, nanosystems made of pure plant polyphenols without other matrix materials and referred to as nanocrystals constitute more stable systems that provide enhanced cell and mitochondrial protection compared to free drugs in cellular and animal ND models (Table 3 and Section 5.4).…”

Section: Nanocarriers Improve Cns Bioavailability Of Plant Compounds With Antioxidative and Neuroprotective Activitymentioning

confidence: 99%

“…PUE has been loaded on GO nanosheets linked to lactoferrin to bind to the vascular endothelial receptor on the BBB and to promote brain access of the therapeutic agent. The Lactoferrin-GO-PUE nanosystem provides significantly higher brain bioavailibity of PUE, reduces oxidative stress and loss of dopamine neurons in the striatum, and restores motor dysfunction of PD mice to a significantly higher extent than free PUE or a non-targeted GO-PUE carrier [198].…”

Section: Nanosystems Containing Antioxidative and Neuroprotective Plant Chemicals To Repair Mitochondrial Function In Neurodegenerationmentioning

confidence: 99%

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Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases

2021

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Mitochondria are vital organelles in eukaryotic cells that control diverse physiological processes related to energy production, calcium homeostasis, the generation of reactive oxygen species, and cell death. Several studies have demonstrated that structural and functional mitochondrial disturbances are involved in the development of different neuroinflammatory (NI) and neurodegenerative (ND) diseases (NI&NDDs) such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Remarkably, counteracting mitochondrial impairment by genetic or pharmacologic treatment ameliorates neurodegeneration and clinical disability in animal models of these diseases. Therefore, the development of nanosystems enabling the sustained and selective delivery of mitochondria-targeted drugs is a novel and effective strategy to tackle NI&NDDs. In this review, we outline the impact of mitochondrial dysfunction associated with unbalanced mitochondrial dynamics, altered mitophagy, oxidative stress, energy deficit, and proteinopathies in NI&NDDs. In addition, we review different strategies for selective mitochondria-specific ligand targeting and discuss novel nanomaterials, nanozymes, and drug-loaded nanosystems developed to repair mitochondrial function and their therapeutic benefits protecting against oxidative stress, restoring cell energy production, preventing cell death, inhibiting protein aggregates, and improving motor and cognitive disability in cellular and animal models of different NI&NDDs.

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“…Inspired by abovementioned pioneering works and integrating our previous experience [ 8 , 43 , 44 ], we attempted to employ the hydroxylated biphenol derived from the ‘Houpo' herb (Magnolia officinalis) known as magnolol (MAG) as a model drug, as it is commonly studied to treat PD [ 45 , 46 ]. To improve the solubility, stability, and bioavailability characteristics of MAG, PVP-K30 was used to stabilize MAG-containing NCs (MAG-NCs).…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease

Tan

Liu

et al. 2021

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Mitochondrial dysfunction is commonly detected in individuals suffering from Parkinson’s disease (PD), presenting within the form of excessive reactive oxygen species (ROS) generation as well as energy metabolism. Overcoming this dysfunction within brain tissues is an effective approach to treat PD, while unluckily, the blood-brain barrier (BBB) substantially impedes intracerebral drug delivery. In an effort to improve the delivery of efficacious therapeutic drugs to the brain, a drug delivery platform hydrogel (MAG-NCs@Gel) was designed by complexing magnolol (MAG)-nanocrystals (MAG-NCs) into the noninvasive thermosensitive poly(N-isopropylacrylamide) (PNIPAM) with self-gelation. The as-prepared MAG-NCs@Gel exhibited obvious improvements in drug solubility, the duration of residence with the nasal cavity, and the efficiency of brain targeting, respectively. Above all, continuous intranasal MAG-NCs@Gel delivery enabled MAG to cross the BBB and enter dopaminergic neurons, thereby effectively alleviating the symptoms of MPTP-induced PD. Taking advantage of the lower critical solution temperature (LCST) behavior of this delivery platform increases its viscoelasticity in nasal cavity, thus improving the efficiency of MAG-NCs transit across the BBB. As such, MAG-NCs@Gel represented an effective delivery platform capable of normalizing ROS and adenosine triphosphate (ATP) in the mitochondria of dopaminergic neurons, consequently reversing the mitochondrial dysfunction and enhancing the behavioral skills of PD mice without adversely affecting normal tissues.

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Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease

Abstract: A brain-targeted drug delivery nanoplatform based on graphene oxide could overcome the blood–brain barrier for the treatment of Parkinson's disease.

Cited by 60 publications

References 50 publications

Effects of graphene on morphology, microstructure and transcriptomic profiling of Pinus tabuliformis Carr. roots

Effects of graphene on morphology, microstructure and transcriptomic profiling of Pinus tabuliformis Carr. roots

Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases

Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease

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