Targeted Phytochemical-Conjugated Gold Nanoparticles in Cancer Treatment

<p>New Approaches in Breast Cancer Therapy Through Green Nanotechnology and Nano-Ayurvedic Medicine – Pre-Clinical and Pilot Human Clinical Investigations</p>

“…In order to understand the extent of loading of mangiferin onto AuNPs, which we refer as drug loading, we have performed key experiments as elaborated in numerous publications on green nanotechnology from our laboratory. [19][20][21]23,26,27,35,61 We hypothesized that the corona around gold nanoparticles in MP-AuNPs comprises of mostly the encapsulation of mangiferin due to the large abundance of this phytochemical in the mango peel ( Figure 5). Validating this hypothesis is significant in understanding drug loading of mangiferin around gold nanoparticles.…”

“…As part of our continued quest to develop scientific rationale for Ayurvedic medicine, we have been researching, for over two decades, on the application of green nanotechnology to develop universally acceptable Ayurvedic formulations. [19][20][21][22][23][24][25][26] Green nanotechnology allows the production and efficient encapsulation of Ayurvedic-relevant phytochemicals on gold nanoparticles. Our long-standing scientific efforts, with a focus on gold nanoparticles, are based on the rationale that in Ayurvedic medicine, gold metal is ubiquitously used in combination with phytochemicals from various herbs including cinnamon, clove, gooseberry, grape, mango, turmeric and a host of herbs.…”

“…Our long-standing scientific efforts, with a focus on gold nanoparticles, are based on the rationale that in Ayurvedic medicine, gold metal is ubiquitously used in combination with phytochemicals from various herbs including cinnamon, clove, gooseberry, grape, mango, turmeric and a host of herbs. [19][20][21][22][23][24][25][26] Our efforts, serendipitously, led to a series of discoveries confirming that the phytochemicals used in Ayurvedic medicines are indeed electron-rich antioxidants and that the interaction of gold metallic precursors with phytochemically-harnessed electrons produced herb/ phytochemicals-encapsulated, well-defined, gold nanoparticles. The large surface area of gold nanoparticles embedded with atomically active nano surface motif allowed highly efficient encapsulation of phytochemical-(s)thus paving, for the first time, an innovative green nanotechnology route providing reproducible and scientifically verifiable Nano-Ayurvedic formulations.…”

“…The large surface area of gold nanoparticles embedded with atomically active nano surface motif allowed highly efficient encapsulation of phytochemical-(s)thus paving, for the first time, an innovative green nanotechnology route providing reproducible and scientifically verifiable Nano-Ayurvedic formulations. [19][20][21][22][23][24] Choice of gold nanoparticles is further necessitated by the fact that this metal embodies the iconic Ayurvedic medication "Swarna Bhasma" (SB) ("Swarna" meaning gold, "Bhasma" meaning ash) which contains gold particles along with various herbal mixtures. Swarna Bhasma is an ancient Indian medicine with established anticancer activity.…”

Bombesin Peptide Conjugated Water-Soluble Chitosan Gallate—A New Nanopharmaceutical Architecture for the Rapid One-Pot Synthesis of Prostate Tumor Targeted Gold Nanoparticles

“…In this context, we have been exploring the utility of green nanotechnology in the design and architecture of tumor-avid gold nanoparticles. 6,9,11,12,14,20,23,26,34 Tumor avidity and selective accumulation of optimum doses of therapeutic gold nanoparticles is of paramount importance in drug delivery. 35,36 Specifically, tumor selectivity and cytotoxicity of NPs depend on many factors, such as particle size, surface chemistry and biological target.…”