Targeted polymerase chain reaction-based expression of putative halitogenic bacteria and volatile sulphur compound analysis among halitosis patients at a tertiary hospital in Nigeria

Adedapo, Adeyinka Happy; Kolude, Bamidele; Dada-Adegbola, Hannah; Lawoyin, J O; Adeola, Henry Ademola

doi:10.1007/s10266-019-00467-x

Cited by 11 publications

(5 citation statements)

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“…In addition, the sensory value, VSC concentration and Prevotella intermedia, F. nucleatum and Campylobacter rectus concentrations of patients with bad breath who clean their tongue were significantly lower than those of patients without this habit (Amou et al, 2014). Adedapo et al (2020) showed that F. nucleatum, P. gingivalis and Prevotella intermedius located on the back of the tongue are the main causes for the increased production of VSCs in patients with halitosis. Bernardi et al (2019) revealed that the dorsal tongue biofilm of patients with halitosis had a significantly higher proportion of F. nucleatum and Streptococcus.…”

Section: Association Between F Nucleatum and Halitosismentioning

confidence: 96%

More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Chen

Huang

Tang

et al. 2022

Front. Cell. Infect. Microbiol.

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Fusobacterium nucleatum is a common oral opportunistic bacterium that can cause different infections. In recent years, studies have shown that F. nucleatum is enriched in lesions in periodontal diseases, halitosis, dental pulp infection, oral cancer, and systemic diseases. Hence, it can promote the development and/or progression of these conditions. The current study aimed to assess research progress in the epidemiological evidence, possible pathogenic mechanisms, and treatment methods of F. nucleatum in oral and systemic diseases. Novel viewpoints obtained in recent studies can provide knowledge about the role of F. nucleatum in hosts and a basis for identifying new methods for the diagnosis and treatment of F. nucleatum-related diseases.

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Section: Association Between F Nucleatum and Halitosismentioning

confidence: 96%

More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Chen

Huang

Tang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…People who have a bad oral odor problem tend not to be aware of their bad breath, while those who do not have a bad breath problem worry excessively about having a bad odor problem. Young and middle-aged people tend to be more alert and anxious about their health, obtaining significantly higher scores in the OLT (organoleptic test, the gold standard to detect bad oral smell) and showing significant symptoms of anxiety and depression, with the anxiety itself increasing oral levels of volatile sulfur compounds (VSCs) [20][21][22][23][24][25][26][27]. A gender difference in the perception of halitosis was highlighted in one study [23]: 21.7% were male and 35.3% were female.…”

Section: Introductionmentioning

confidence: 99%

Adolescence, Adulthood and Self-Perceived Halitosis: A Role of Psychological Factors

et al. 2021

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(1) Background: Halitosis is a frequent condition that affects a large part of the population. It is considered a “social stigma”, as it can determine a number of psychological and relationship consequences that affect people’s lives. The purpose of this review is to examine the role of psychological factors in the condition of self-perceived halitosis in adolescent subjects and adulthood. (2) Type of studies reviewed: We conducted, by the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) guidelines, systematic research of the literature on PubMed and Scholar. The key terms used were halitosis, halitosis self-perception, psychological factors, breath odor and two terms related to socio-relational consequences (“Halitosis and Social Relationship” OR “Social Issue of Halitosis”). Initial research identified 3008 articles. As a result of the inclusion and exclusion criteria, the number of publications was reduced to 38. (3) Results: According to the literature examined, halitosis is a condition that is rarely self-perceived. In general, women have a greater ability to recognize it than men. Several factors can affect the perception of the dental condition, such as socioeconomic status, emotional state and body image. (4) Conclusion and practical implication: Self-perceived halitosis could have a significant impact on the patient’s quality of life. Among the most frequent consequences are found anxiety, reduced levels of self-esteem, misinterpretation of other people’s attitudes and embarrassment and relational discomfort that often result in social isolation.

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“…In the recent past, the most studied bacteria in patients with halitosis were the Gram-negative Fusobacterium nucleatum, Porphryomonas gingivalis, Treponema denticola, and Tannerella forsythia [ 32 – 38 ]. For this reason, one of our objectives was to quantify these bacteria on the dorsum of the tongue.…”

Section: Discussionmentioning

confidence: 99%

Short term effect of antimicrobial photodynamic therapy and probiotic L. salivarius WB21 on halitosis: A controlled and randomized clinical trial

Motta,

Gonçalves,

Gallo

et al. 2024

PLoS ONE

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Objective This study aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) and the use of probiotics on the treatment of halitosis. Methods Fifty-two participants, aged from 18 to 25 years, exhaling sulfhydride (H2S) ≥ 112 ppb were selected. They were allocated into 4 groups (n = 13): Group 1: tongue scraper; Group 2: treated once with aPDT; Group 3: probiotic capsule containing Lactobacillus salivarius WB21 (6.7 x 108 CFU) and xylitol (280mg), 3 times a day after meals, for 14 days; Group 4: treated once with aPDT and with the probiotic capsule for 14 days. Halimetry with gas chromatography (clinical evaluation) and microbiological samples were collected from the dorsum of the tongue before and after aPDT, as well as after 7, 14, and 30 days. The clinical data failed to follow a normal distribution; therefore, comparisons were made using the Kruskal-Wallis test (independent measures) and Friedman ANOVA (dependent measures) followed by appropriate posthoc tests, when necessary. For the microbiological data, seeing as the data failed to follow a normal distribution, the Kruskal-Wallis rank sum test was performed with Dunn’s post-test. The significance level was α = 0.05. Results Clinical results (halimetry) showed an immediate significant reduction in halitosis with aPDT (p = 0.0008) and/or tongue scraper (p = 0.0006). Probiotics showed no difference in relation to the initial levels (p = 0.7530). No significant differences were found in the control appointments. The amount of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were not altered throughout the analysis (p = 0.1616, p = 0.2829 and p = 0.2882, respectively). Conclusion There was an immediate clinical reduction of halitosis with aPDT and tongue scraping, but there was no reduction in the number of bacteria throughout the study, or differences in the control times, both in the clinical and microbiological results. New clinical trials are necessary to better assess the tested therapies. Trial registration Clinical Trials NCT03996044.

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Targeted polymerase chain reaction-based expression of putative halitogenic bacteria and volatile sulphur compound analysis among halitosis patients at a tertiary hospital in Nigeria

Cited by 11 publications

References 50 publications

More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Adolescence, Adulthood and Self-Perceived Halitosis: A Role of Psychological Factors

Short term effect of antimicrobial photodynamic therapy and probiotic L. salivarius WB21 on halitosis: A controlled and randomized clinical trial

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