Targeted regulation of tumor microenvironment through the inhibition of MDSCs by curcumin loaded self-assembled nano-filaments

Nanomedicine Targeting Myeloid‐Derived Suppressor Cells Enhances Anti‐Tumor Immunity

“…Moreover, strategies for the preparation and storage of nanomedicines require refinement to facilitate industrial production and ensure quality assurance. [70] Copyright 2022, Elsevier. B) Schematic illustration depicting how Tel@PGE reprograms the immunosuppressive TME, fostering a systemic antitumor immune response to thwart postoperative tumor recurrence and metastasis.…”

Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

“…Wang et al. 165 proposed a self-assembled nano-filament system through the conjugation of MDSCs repressor curcumin and a self-assembled peptide FFE-ss-EE (denoted as Nano-Cur) for lung cancer. Given that Cur was verified to have potential inhibitory capacities on MDSCs but was restricted by its poor bioavailability and tumor accumulation, researchers exploited self-assembled peptide-based nano-filaments to improve the loading capacity and retention effect of curcumin 166 .…”

LncRNAs has been identified as regulators of Myeloid-derived suppressor cells in lung cancer

“…Although some of these treatments are used as first-line therapy, the clinical studies mentioned above have shown that MDSCs can not only exert be immunosuppressive in the TME but could directly promote tumour advancement but also interfere with the prognosis of conventional treatments, thus making it more critical to treat lung cancer by targeting MDSCs. MDSCs were proposed as potential targets for the advance of anti-cancer lung treatment based on the following five aspects ( 1 ): promotion of myeloid differentiation ( 2 ); blockage of MDSC propagation ( 3 ); removal of MDSCs ( 4 ); functional decay of MDSCs, and ( 5 ) blockade of immune checkpoints ( 63 ).Further research on MDSCs showed that miRNAs/lncRNAs could regulate the specialization, propagation, and immunosuppressive roles of MDSCs in TME ( 64 ). Therefore, targeting miRNAs and lncRNAs to stop the development and expansion of MDSCs suppressor cells in the tumour environment appears more promising.…”

“…As early as 1970, studies have pointed out the MDSCs relation to tumour development ( 4 ). Its role in the tumour microenvironment has been pivotal and turned into a new target for cancer therapy ( 5 ). In a study by Gabrilovich and Nagaraj, the authors confirmed that MDSCs are heterogeneous cell populations derivative from the bone marrow precursor and immature cells (IMC).…”