2009
DOI: 10.1089/ars.2009.2637
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Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases

Abstract: Nox family NADPH oxidases serve a variety of functions requiring reactive oxygen species (ROS) generation, including antimicrobial defense, biosynthetic processes, oxygen sensing and redox-based cellular signaling. We explored targeting, assembly, and activation of several Nox family oxidases, since ROS production appears to be regulated both spatially and temporally. Nox1 and Nox3 are similar to the phagocytic (Nox2-based) oxidase, functioning as superoxide-generating multi-component enzymes. Factors regulati… Show more

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Cited by 306 publications
(300 citation statements)
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“…To elucidate the mechanism responsible for apoptosis induction by midazolam, we investigated the effect of midazolam on intracellular ROS production. ROS generation in cancer cells is observed also through non-mitochondrial sources such as membrane bound NADPH oxidases (Bae et al, 2011;Leto et al, 2009). Nox2 and Nox4 are the membrane bound nonmitochondrial sources of intracellular ROS generation that has been also been associated with the growth promotion in cancer cells (Jeon et al, 2010;Leto et al, 2009;Rao Malla et al, 2010).…”
Section: Midazolam Suppressed the Intracellular Ros Generation In K56mentioning
confidence: 99%
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“…To elucidate the mechanism responsible for apoptosis induction by midazolam, we investigated the effect of midazolam on intracellular ROS production. ROS generation in cancer cells is observed also through non-mitochondrial sources such as membrane bound NADPH oxidases (Bae et al, 2011;Leto et al, 2009). Nox2 and Nox4 are the membrane bound nonmitochondrial sources of intracellular ROS generation that has been also been associated with the growth promotion in cancer cells (Jeon et al, 2010;Leto et al, 2009;Rao Malla et al, 2010).…”
Section: Midazolam Suppressed the Intracellular Ros Generation In K56mentioning
confidence: 99%
“…Thus oxidative stress has emerged as an important pathogenic factor in the development of cancer. Mitochondria are the main source of ROS generation; however, non-mitochondrial production of superoxide anion via the NADPH oxidase pathway has also been reported in cancer cells (Leto et al, 2009). ROS generation in cancer cells is observed also through non-mitochondrial sources involving membrane bound NADPH oxidases (Bae et al, 2011;Leto et al, 2009).…”
Section: +mentioning
confidence: 99%
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“…However, the source of ROS and the mechanisms involved in the effects have not yet been elucidated. It is known that the NADPH oxidase complex is the most important intracellular source of ROS apart from mitochondria (Babior, 1999(Babior, , 2004Seshiah et al, 2002;Cai et al, 2003) and that it generates and releases ROS in short oxidative bursts for signaling functions (Bokoch and Knaus, 2003;Ritsick et al, 2004;Leto et al, 2009). In addition, several studies support a critical role for mitochondrial ATP-sensitive potassium channels (mitoKATP) in modulating intracellular ROS (Mattson and Liu, 2003;Costa and Garlid, 2008) by means of regulation of the formation/ release of ROS from the mitochondria, and integration of signals from diverse sources Facundo et al, 2007;Fornazari et al, 2008).…”
Section: Introductionmentioning
confidence: 99%