Targeting antimicrobial drug resistance with marine natural products

Barbosa, Filipa; Pinto, Eugénia; Kijjoa, Anake; Pinto, Madalena; Sousa, Emília

doi:10.1016/j.ijantimicag.2020.106005

Cited by 66 publications

(46 citation statements)

References 114 publications

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“…Since these species are associated with metabolites with different biological activities, the selection of F. equiseti and Alternaria spp. from a screening of 31 identified strains led to the extraction of two new anthraquinone derivatives 67 and 68, and two perylenequinones, stemphyperlenol (69) and alterpeylenol (70) (Figure 18). The compounds were tested for antifungal activity against a wide spectrum of six pathogenic fungi: Alternaria alternata, Alternaria brassicicola, Phytophthora parasitica var.…”

Section: Fungi-derived Compoundsmentioning

confidence: 99%

Marine-Derived Compounds and Prospects for Their Antifungal Application

et al. 2020

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The introduction of antifungals in clinical practice has an enormous impact on the provision of medical care, increasing the expectancy and quality of life mainly of immunocompromised patients. However, the emergence of pathogenic fungi that are resistant and multi-resistant to the existing antifungal therapy has culminated in fungal infections that are almost impossible to treat. Therefore, there is an urgent need to discover new strategies. The marine environment has proven to be a promising rich resource for the discovery and development of new antifungal compounds. Thus, this review summarizes more than one hundred marine natural products, or their derivatives, which are categorized according to their sources—sponges, bacteria, fungi, and sea cucumbers—as potential candidates as antifungal agents. In addition, this review focus on recent developments using marine antifungal compounds as new and effective approaches for the treatment of infections caused by resistant and multi-resistant pathogenic fungi and/or biofilm formation; other perspectives on antifungal marine products highlight new mechanisms of action, the combination of antifungal and non-antifungal agents, and the use of nanoparticles and anti-virulence therapy.

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Section: Fungi-derived Compoundsmentioning

confidence: 99%

Marine-Derived Compounds and Prospects for Their Antifungal Application

et al. 2020

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“…Approximately 70% of the Earth’s surface is covered by marine waterand thus, the marine world is home to a huge diversity of species. Several organisms have been proposed as sources of known beneficial compounds and other new molecules with biological potential [ 1 , 2 ]. Nowadays, there are more than 200,000 eukaryotic marine species validated, among which, algae contribute nearly 44,000 described species [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…In Figure 1 , a schematic summary of the main resistance acquisition pathways (fundamentally by mutation or by acquiring mobile genetic elements with resistance genes) [ 22 ] and the main mechanisms of resistance to antibiotics is shown. In this context, marine macroalgae have shown antimicrobial potential and in some cases, a synergistic effect with conventional antimicrobial agents against drug-resistant pathogens [ 1 ]. Thus, this association can be applied to the pharmaceutical sector and also to the food industry, where consumer resistance is also a reality and food-spoilage-microorganisms control is a must in the food chain supply [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Once the target compounds are efficiently well extracted, the resultant extracts can be incorporated into different products. In general, the most common application would be the incorporation into food matrixes as preservatives [ 25 ], to cosmetic products [ 31 ] or as antibiotics with a synergistic effect on the pharmaceutical industry [ 1 ]. Moreover, other applications have been investigated such as antibiofilm [ 32 ], antifouling [ 33 ], coating in active packaging [ 34 ] or as prebiotics [ 11 ], among others.…”

Section: Introductionmentioning

confidence: 99%

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Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications

et al. 2020

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In the last few decades, attention on new natural antimicrobial compounds has arisen due to a change in consumer preferences and the increase in the number of resistant microorganisms. Macroalgae play a special role in the pursuit of new active molecules as they have been traditionally consumed and are known for their chemical and nutritional composition and their biological properties, including antimicrobial activity. Among the bioactive molecules of algae, proteins and peptides, polysaccharides, polyphenols, polyunsaturated fatty acids and pigments can be highlighted. However, for the complete obtaining and incorporation of these molecules, it is essential to achieve easy, profitable and sustainable recovery of these compounds. For this purpose, novel liquid–liquid and solid–liquid extraction techniques have been studied, such as supercritical, ultrasound, microwave, enzymatic, high pressure, accelerated solvent and intensity pulsed electric fields extraction techniques. Moreover, different applications have been proposed for these compounds, such as preservatives in the food or cosmetic industries, as antibiotics in the pharmaceutical industry, as antibiofilm, antifouling, coating in active packaging, prebiotics or in nanoparticles. This review presents the main antimicrobial potential of macroalgae, their specific bioactive compounds and novel green extraction technologies to efficiently extract them, with emphasis on the antibacterial and antifungal data and their applications.

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“…Nature is undoubtedly the richest source of molecules with the most varied biological features. Due to its biodiversity not only between animal and plant kingdoms, but also among the various species, nature represents the largest library of compounds that has ever existed [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections

et al. 2020

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Antibiotic resistance is now considered a worldwide problem that puts public health at risk. The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new drugs have prompted scientific research to re-evaluate natural products as molecules with high biological and chemical potential. A class of natural compounds of significant importance is represented by alkaloids derived from higher plants. In this review, we have collected data obtained from various research groups on the antimicrobial activities of these alkaloids against conventional antibiotic-resistant strains. In addition, the structure–function relationship was described and commented on, highlighting the high potential of alkaloids as antimicrobials.

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Targeting antimicrobial drug resistance with marine natural products

Cited by 66 publications

References 114 publications

Marine-Derived Compounds and Prospects for Their Antifungal Application

Marine-Derived Compounds and Prospects for Their Antifungal Application

Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications

Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections

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