Targeting BMI1 and MCL1 for Lung Adenocarcinoma Treatment

Lin, E. K.; Hsu, Chuan-Yu; Y, Jan; Lin, Tao; Chang, Hsiu-Ju; Cheng, Chunming; Hsu, Hui‐Chen; Chen, W; Chen, B; Tsai, Henry J.; Li, Jian; Huang, Chi-Ying F.; Chuang, Shuang‐En; Chang, Jia‐Ming; Hsiao, Michael; Wu, Chunfu

doi:10.1101/344275

Cited by 3 publications

(3 citation statements)

References 46 publications

(72 reference statements)

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“…Sin embargo, para muchos otros ese grado de inmersión y de focalización les acerca al estado de flujo (Csikszentmihalyi, 1997) en el que llegan a perder la noción del mismo, un estado muy deseable en los procesos formativos. Hay evidencia científica de que la capacidad de abstracción del alumnado tiene una relación directa con el desarrollo del pensamiento creativo (Lin et al, 2013), lo que también se vincula con el disfrute o diversión, pues cuando los estudiantes se sienten cómodos, con sentimientos positivos, se desarrolla este tipo de pensamiento (Agnoli et al, 2018).…”

Section: Discussionunclassified

El escape room como estrategia didáctica en el Máster de Profesorado (Escape room as a didactical strategy in the Master’s degree in Teacher Learning)

Mateos

Pérez-López

2021

Retos

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Ante la falta de motivación del alumnado universitario, se hacen necesarias metodologías activas que les brinden un rol protagonista dentro del proceso de enseñanza-aprendizaje. Dentro de ellas encontramos el aprendizaje basado en juegos, destacando el enorme auge en los últimos años de los escape rooms en los procesos formativos. En este artículo se pretende analizar lo que este tipo de planteamientos puede generar en el contexto universitario, a través de las percepciones y valoraciones del alumnado del máster de profesorado, tras participar en un escape room digital basado en la película Matrix. La metodología utilizada fue mixta, utilizando la escala GAMEX para obtener datos cuantitativos sobre cada una de las dimensiones que esta mide, relacionadas con la participación en experiencias gamificadas. Esta información se complementó con un cuestionario con una única pregunta abierta para que pudieran compartir sus opiniones y experiencias, haciendo un procesamiento cualitativo de dicha información. Los resultados muestran valores muy positivos en el disfrute/diversión, el grado de absorción, el pensamiento creativo y dominio y la activación del alumnado. Además, el planteamiento potenció la gestión emocional, fundamental en los futuros docentes, pues también aparecen sentimientos como la frustración o la molestia. El hecho de vivir estas experiencias en primera persona permite a los estudiantes conocer su potencial y dificultades de cara a poder aplicarlas en un futuro en las aulas. Abstract. When facing the lack of motivation of university students, it is necessary to use active methodologies which will provide the students with an active role. Among them, we find game-based learning, we highlight the huge peak in the last few years of escape rooms among the formative processes. In this article, we analyse what can be generated in the university context with this type of approach, through the perceptions and reviews of the student body from the MA in Teaching after they take part in a digital escape room based on the movie Matrix. The employed methodology is a mixed one, using the GAMEX scale to obtain quantitative data about every single one of the dimensions measured by the scale that are relates to the participation in gamified experiences. This information was complemented with an open-question based questionnaire so the students could share their opinions and experiences, making use of qualitative way of processing this information. The results show very positive values in the enjoyment/fun, grade of absorption, creative thinking and dominion and the student body’s activation. Furthermore, this approach boosted emotional management, something fundamental in future teachers since they also feel frustration or annoyance. The fact they lived this experience directly allows the students to know their potential and their difficulties so they can apply them in the future.

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Section: Discussionunclassified

El escape room como estrategia didáctica en el Máster de Profesorado (Escape room as a didactical strategy in the Master’s degree in Teacher Learning)

Mateos

Pérez-López

2021

Retos

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“…13 Recently, Chen and co-workers put forward an exosome proteome profiling method by detecting the protein extracts using MALDI-TOF MS, showing the potentials of this MS technique in exosome analysis. 14 Here, instead of protein extracts, the exosome entities are detected directly. The detection rationale is the combination of organic compound penetration and laser irradiation of the vesicles during the MALDI process.…”

Section: The Bigger Picturementioning

confidence: 99%

MALDI Detection of Exosomes: A Potential Tool for Cancer Studies

Zhu

Pick

Gasilova

et al. 2019

Chem

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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry is used to detect intact whole exosomes, yielding exosomal fingerprints within minutes. This rapid exosome detection approach is proposed as a potential tool for cancer studies. Melanoma, a dangerous form of skin cancer, is investigated as a cancer model. The approach allows classification of melanoma cell lines from the stage level through mathematical analysis of the fingerprints and enables the tracking of protein transfer from parental cells to the secreted exosomes by following up certain fingerprint peaks. Protein identities of exosomal fingerprint peaks were clarified by correlation with top-down and bottom-up proteomics. The protein-assigned fingerprints provide a qualitative and semiquantitative detection of melanoma biomarkers and help to explore melanoma progression via exosome-mediated intercellular communication. Targeting bloodstream-circulating exosomes, the proposed exosome fingerprinting approach also promises fast detection of melanoma diseases and dynamic monitoring of the disease state with proof of concept in mouse and human.

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“…Несмотря на то, что такие состояния, как метаболический синдром [67], дислипидемия [68], ожирение, высокий уровень глюкозы в крови натощак [67] и синдром поликистозных яичников [69] [84]. Длительное сочетанное воздействие O 3 и SO 2 связано с более высоким риском развития сахарного диабета II типа у взрослых [85].…”

Section: влияние загрязнения атмосферного воздуха на здоровье человекаunclassified

Effects of atmospheric air pollutants on human health (overview)

Raikova,

Gusev,

Mazilov

et al. 2023

TaAE

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One of modern humanity’s global scourges is air pollution on account not only of its influence on climate change but also its significant impact on public health. A review of current data on the effects of priority atmospheric air pollutants on human health was carried out. The search was performed using eLIBRARY.RU, Web of Science, Scopus and PubMed, in a time span of 2017–2022. Particulate matter (with a diameter of 2.5 μm (PM2.5) or less and 10 μm (PM10) or less) and nitrogen dioxide (NO2) were the most widely investigated pollutants in the context of health effects. Recently, however, there has been growing interest in the health effects of ozone. Despite the fact that most of the works were devoted to the study of the influence of pollutants on the respiratory and cardiovascular systems, recently the vector of scientific interests shifted to determine the possible role of pollutants in the formation of mental disorders, pathologies of central nervous and endocrine systems, reproductive function. Data on the association of prolonged exposure to nitrogen dioxide, PM2.5, carbon monoxide and ozone with increased morbidity and mortality from SARS-CoV-2 were provided. Prolonged exposure to concentrations well below current standards has been found to have a significant negative impact on the health of both adults and children. Further research in this area is needed to address the possible correction of modern air quality standards.

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Targeting BMI1 and MCL1 for Lung Adenocarcinoma Treatment

Cited by 3 publications

References 46 publications

El escape room como estrategia didáctica en el Máster de Profesorado (Escape room as a didactical strategy in the Master’s degree in Teacher Learning)

El escape room como estrategia didáctica en el Máster de Profesorado (Escape room as a didactical strategy in the Master’s degree in Teacher Learning)

MALDI Detection of Exosomes: A Potential Tool for Cancer Studies

Effects of atmospheric air pollutants on human health (overview)

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