Targeting Brain Tumors with Mesenchymal Stem Cells in the Experimental Model of the Orthotopic Glioblastoma in Rats

Yudintceva, Natalia; Lomert, Ekaterina; Mikhailova, Natalia; Tolkunova, Elena; Agadzhanian, Nikol; Samochernych, Konstantin; Multhoff, Gabriele; Timin, G.; Ryzhov, V. A.; Deriglazov, V. V.; Mazur, Anton S.; Shevtsov, Maxim

doi:10.3390/biomedicines9111592

Cited by 8 publications

(9 citation statements)

References 51 publications

(66 reference statements)

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“…When SPION-labeled MSCs were administered intravenously in living organisms, the tagged cells accumulated inside the tumor site. This dramatically improved the tumor’s contrast on high-field magnetic resonance imaging [ 137 ].…”

Section: Metallic Nanoparticles For Tissue Engineeringmentioning

confidence: 99%

Scaffold Using Chitosan, Agarose, Cellulose, Dextran and Protein for Tissue Engineering—A Review

et al. 2023

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Biological macromolecules like polysaccharides/proteins/glycoproteins have been widely used in the field of tissue engineering due to their ability to mimic the extracellular matrix of tissue. In addition to this, these macromolecules are found to have higher biocompatibility and no/lesser toxicity when compared to synthetic polymers. In recent years, scaffolds made up of proteins, polysaccharides, or glycoproteins have been highly used due to their tensile strength, biodegradability, and flexibility. This review is about the fabrication methods and applications of scaffolds made using various biological macromolecules, including polysaccharides like chitosan, agarose, cellulose, and dextran and proteins like soy proteins, zein proteins, etc. Biopolymer-based nanocomposite production and its application and limitations are also discussed in this review. This review also emphasizes the importance of using natural polymers rather than synthetic ones for developing scaffolds, as natural polymers have unique properties, like high biocompatibility, biodegradability, accessibility, stability, absence of toxicity, and low cost.

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Section: Metallic Nanoparticles For Tissue Engineeringmentioning

confidence: 99%

Scaffold Using Chitosan, Agarose, Cellulose, Dextran and Protein for Tissue Engineering—A Review

et al. 2023

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“…Using MSCs as a delivery system for NPs is controversial for their unpredictable effects [ 131 ]. However, there is still some successful evidence of the application of MSC-based NP delivery in vivo models [ 132 , 133 , 134 ].…”

Section: Chemical Modification Of the Btb Permeabilitymentioning

confidence: 99%

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

et al. 2023

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Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic (i.e., theranostic) potencies in translational oncology, and some agents have been further translated into clinical trials. However, the practical application of nanoparticle-based medicine in living organisms is limited by physiological barriers (blood–tissue barriers), which significantly hampers the transport of nanoparticles from the blood into the tumor tissue. This review focuses on several approaches that facilitate the translocation of nanoparticles across blood–tissue barriers (BTBs) to efficiently accumulate in the tumor. To overcome the challenge of BTBs, several methods have been proposed, including the functionalization of particle surfaces with cell-penetrating peptides (e.g., TAT, SynB1, penetratin, R8, RGD, angiopep-2), which increases the passing of particles across tissue barriers. Another promising strategy could be based either on the application of various chemical agents (e.g., efflux pump inhibitors, disruptors of tight junctions, etc.) or physical methods (e.g., magnetic field, electroporation, photoacoustic cavitation, etc.), which have been shown to further increase the permeability of barriers.

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“…Due to their therapeutic potential and unique properties, MSCs are appealing for various fields of regenerative medicine [ 51 , 52 ], cancer therapy [ 53 , 54 , 55 ], and infectious diseases [ 20 , 56 , 57 , 58 , 59 ]. MSCs synthesize factors that can restore damaged tissues.…”

Section: Mscs and Msc-derived Extracellular Vesicles (Msc-evs)mentioning

confidence: 99%

Mesenchymal Stem Cells and MSCs-Derived Extracellular Vesicles in Infectious Diseases: From Basic Research to Clinical Practice

et al. 2022

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Mesenchymal stem cells (MSCs) are attractive in various fields of regenerative medicine due to their therapeutic potential and complex unique properties. Basic stem cell research and the global COVID-19 pandemic have given impetus to the development of cell therapy for infectious diseases. The aim of this review was to systematize scientific data on the applications of mesenchymal stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) in the combined treatment of infectious diseases. Application of MSCs and MSC-EVs in the treatment of infectious diseases has immunomodulatory, anti-inflammatory, and antibacterial effects, and also promotes the restoration of the epithelium and stimulates tissue regeneration. The use of MSC-EVs is a promising cell-free treatment strategy that allows solving the problems associated with the safety of cell therapy and increasing its effectiveness. In this review, experimental data and clinical trials based on MSCs and MSC-EVs for the treatment of infectious diseases are presented. MSCs and MSC-EVs can be a promising tool for the treatment of various infectious diseases, particularly in combination with antiviral drugs. Employment of MSC-derived EVs represents a more promising strategy for cell-free treatment, demonstrating a high therapeutic potential in preclinical studies.

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Targeting Brain Tumors with Mesenchymal Stem Cells in the Experimental Model of the Orthotopic Glioblastoma in Rats

Cited by 8 publications

References 51 publications

Scaffold Using Chitosan, Agarose, Cellulose, Dextran and Protein for Tissue Engineering—A Review

Scaffold Using Chitosan, Agarose, Cellulose, Dextran and Protein for Tissue Engineering—A Review

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

Mesenchymal Stem Cells and MSCs-Derived Extracellular Vesicles in Infectious Diseases: From Basic Research to Clinical Practice

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