Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene

Zhang, Lingling; Wen, Xiang; Li, Mengmeng; Li, Shiming; Zhao, Hui

doi:10.1002/biof.1398

Cited by 46 publications

(26 citation statements)

References 46 publications

(43 reference statements)

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“…Resveratrol promotes sensitivity to radiation and can downregulate androgen receptor (AR). Several in vivo studies in mice have suggested that resveratrol inhibits generation and proliferation of spontaneous PCs and xenograft malignancies [20]. In our study, we discovered that resveratrol suppressed cell survival and enhanced cell death in TRAMP cells characterized by elevated ROS level.…”

Section: Discussionsupporting

confidence: 54%

Resveratrol Induces Apoptosis in Murine Prostate Cancer Cells via Hypoxia-Inducible Factor 1-alpha (HIF-1α)/Reactive Oxygen Species (ROS)/P53 Signaling

2018

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BackgroundResveratrol, a polyphenol found on the surface of red fruits, is able to suppress many kinds of malignancies. Nevertheless, its mechanism of action is not yet clear. Consequently, this study aimed to elucidate its influence and explore the etiology of PCCs (prostate cancer cells).Material/MethodsThe proliferation of prostate cancer cells was determined by CCK-8 assay. Cell apoptosis was determined by Hoechst staining FC assay. Cell migration was detected by scratch test. The levels of apoptosis-related protein were detected by Western blot analysis.ResultsIt was discovered that resveratrol suppresses cellular survival and migration and enhances cell death. In addition, it was revealed that resveratrol elevated ROS concentration and expression of biomarker of cell death Bax, while inhibiting Bcl2, an anti-apoptotic protein, and reinforcing expression of p53. Moreover, resveratrol remarkably increased the expressions of HIF-1α and p53 in PC cells. Resveratrol suppressed cell survival and promoted cell death, but its effects were reversed after HIF-1α knockdown, suggesting that the effects of resveratrol in PC are mediated via HIF-1α.ConclusionsOur findings indicate that resveratrol induces apoptosis via HIF-1α/ROS/p53 signaling in prostate cancer cells and may be a useful therapeutic agent against prostate cancer.

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Section: Discussionsupporting

confidence: 54%

Resveratrol Induces Apoptosis in Murine Prostate Cancer Cells via Hypoxia-Inducible Factor 1-alpha (HIF-1α)/Reactive Oxygen Species (ROS)/P53 Signaling

2018

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“…Several clinical trials are currently underway [NCT00721877, NCT00920803, NCT00433576, and NCT00578396]. Pterostilbene, a dimethylated derivative of resveratrol with a higher bioavailability and is more lipophilic, exerts more potent suppressive activity against CSCs and cancer metastasis [ 211 , 212 ].…”

Section: Targeting Lipid Metabolism As Novel Therapeutic Strategies Amentioning

confidence: 99%

Emerging role of lipid metabolism alterations in Cancer stem cells

Man

Chen

et al. 2018

J Exp Clin Cancer Res

181

149

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BackgroundCancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsible for relapse or disease recurrence in cancer patients. Stem cells have distinct metabolic properties compared to differentiated cells, and metabolic rewiring contributes to self-renewal and stemness maintenance in CSCs.Main bodyRecent advances in metabolomic detection, particularly in hyperspectral-stimulated raman scattering microscopy, have expanded our knowledge of the contribution of lipid metabolism to the generation and maintenance of CSCs. Alterations in lipid uptake, de novo lipogenesis, lipid droplets, lipid desaturation, and fatty acid oxidation are all clearly implicated in CSCs regulation. Alterations on lipid metabolism not only satisfies the energy demands and biomass production of CSCs, but also contributes to the activation of several important oncogenic signaling pathways, including Wnt/β-catenin and Hippo/YAP signaling. In this review, we summarize the current progress in this attractive field and describe some recent therapeutic agents specifically targeting CSCs based on their modulation of lipid metabolism.ConclusionIncreased reliance on lipid metabolism makes it a promising therapeutic strategy to eliminate CSCs. Targeting key players of fatty acids metabolism shows promising to anti-CSCs and tumor prevention effects.

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“…In vitro, pterostilbene inhibited the proliferation of a variety of tumor cells, including stomach, lung, liver, oral cavity, pancreas, lymph, colon, prostate, breast, melanoma, leukemia, and myeloma tumor cells. In vivo, pterostilbene inhibited tumor occurrence and metastasis and showed almost no toxicity [44,45]. Manlio et al found that pterostilbene had a stronger ability to induce the apoptosis of chronic myeloid leukemia cells than resveratrol.…”

Section: Anti-tumor Activitymentioning

confidence: 99%

Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol

et al. 2020

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Pterostilbene is a natural 3,5-dimethoxy analog of resveratrol. This stilbene compound has a strong bioactivity and exists widely in Dalbergia and Vaccinium spp. Besides natural extraction, pterostilbene can be obtained by biosynthesis. Pterostilbene has become popular because of its remarkable pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammation, and neuroprotection. Pterostilbene can be rapidly absorbed and is widely distributed in tissues, but it does not seriously accumulate in the body. Pterostilbene can easily pass through the blood-brain barrier because of its low molecular weight and good liposolubility. In this review, the studies performed in the last three years on resources, synthesis, bioactivity, and pharmacokinetics of pterostilbene are summarized. This review focuses on the effects of pterostilbene on certain diseases to explore its targets, explain the possible mechanism, and look for potential therapeutic applications.

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Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene

Cited by 46 publications

References 46 publications

Resveratrol Induces Apoptosis in Murine Prostate Cancer Cells via Hypoxia-Inducible Factor 1-alpha (HIF-1α)/Reactive Oxygen Species (ROS)/P53 Signaling

Resveratrol Induces Apoptosis in Murine Prostate Cancer Cells via Hypoxia-Inducible Factor 1-alpha (HIF-1α)/Reactive Oxygen Species (ROS)/P53 Signaling

Emerging role of lipid metabolism alterations in Cancer stem cells

Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol

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