Targeting Cancer Via Resveratrol-Loaded Nanoparticles Administration: Focusing on In Vivo Evidence

Santos, Ana Cláudia; Pereira, Irina; Magalhães, Mariana; Pereira-Silva, Miguel; Caldas, Mariana; Ferreira, Laura Fernandes; Figueiras, Ana; Ribeiro, Antônio J.; Veiga, Francisco

doi:10.1208/s12248-019-0325-y

Cited by 31 publications

(19 citation statements)

References 118 publications

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“…Nanoparticle formulations even enhanced the therapeutic potential and efficacy of RE, especially its in vivo anti-cancer activities in several cancer types. RE was able to increase RE bio-distribution and decrease the tumor size of gliomas, as well as ovarian and colorectal cancers [211,212]. Further advancements in RE carrier delivery should help alleviate the harmful effects of high doses of RE, not only in cancer treatment but also in other diseases where RE showed therapeutic effects.…”

Section: Enhancement Of Pharmacokinetics Using Bio-enhancers and Nanomentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

442

293

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Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects.In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

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Section: Enhancement Of Pharmacokinetics Using Bio-enhancers and Nanomentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

442

293

View full text Add to dashboard Cite

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“…Interestingly, it was found that resveratrol-loaded HSA combined with folic acid slowed down the drug release at the injection site, whereas HSA encapsulated resveratrol without folic acid led to a considerably higher accumulation of resveratrol in tumor. In addition, resveratrol-loaded HSA nanoparticles merged with folic acid was 6-fold more bioavailable than the application of free polyphenol (Ackova et al, 2019 ; Chaudhary et al, 2019 ; Lian et al, 2019 ; Santos et al, 2019 ). In another study, it was observed that folic acid-conjugated resveratrol in combination with docetaxel nanoparticle significantly enhanced the level of apoptotic PC cells by 30.9% and 65.9%, respectively.…”

Section: Resveratrol As a Nanodrugmentioning

confidence: 99%

Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

Sharifi‐Rad

Quispe

Mukazhanova

et al. 2021

Front. Mol. Biosci.

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Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.

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“…Unfortunately, the future use of RSV is limited due to its low bioavailability and fast metabolism [32,90]. Thus, further studies should focus on developing RSV transport systems to the destination [91][92][93].…”

Section: Therapeutic Potential Of Resveratrol In Bcmentioning

confidence: 99%

“…Moreover, according to clinical studies, some of these compounds, such as RSV, quercetin, are characterized by poor bioavailability and poor stability [32,100,102]. However, this issue may be conquered by new transport strategies based on nanoparticles or encapsulation, which provide more stability and better bioavailability of these compounds in anticancer therapies [91][92][93]103]. Another significant problem is the size of the dose that should be used in the treatment of patients with BC.…”

Section: Galusan 3epigallokatechiny (Egcg)mentioning

confidence: 99%

The Green Anti-Cancer Weapon. The Role of Natural Compounds in Bladder Cancer Treatment

Wigner

Bijak

Saluk‐Bijak

2021

IJMS

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Bladder cancer (BC) is the second most common genitourinary cancer. In 2018, 550,000 people in the world were diagnosed with BC, and the number of new cases continues to rise. BC is also characterized by high recurrence risk, despite therapies. Although in the last few years, the range of BC therapy has considerably widened, it is associated with severe side effects and the development of drug resistance, which is hampering treatment success. Thus, patients are increasingly choosing products of natural origin as an alternative or complementary therapeutic options. Therefore, in this article, we aim to elucidate, using the available literature, the role of natural substances such as curcumin, sulforaphane, resveratrol, quercetin, 6-gingerol, delphinidin, epigallocatechin-3-gallate and gossypol in the BC treatment. Numerous clinical and preclinical studies point to their role in the modulation of the signaling pathways, such as cell proliferation, cell survival, apoptosis and cell death.

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Targeting Cancer Via Resveratrol-Loaded Nanoparticles Administration: Focusing on In Vivo Evidence

Cited by 31 publications

References 118 publications

Potential Adverse Effects of Resveratrol: A Literature Review

Potential Adverse Effects of Resveratrol: A Literature Review

Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

The Green Anti-Cancer Weapon. The Role of Natural Compounds in Bladder Cancer Treatment

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