2019
DOI: 10.1038/s41568-019-0135-7
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Targeting cancer vulnerabilities with high-dose vitamin C

Abstract: Over the past century, the notion that vitamin C can be used to treat cancer has generated much controversy. However, new knowledge regarding the pharmacokinetic properties of vitamin C and recent high-profile preclinical studies have revived interest in the utilization of high-dose vitamin C for cancer treatment. Studies have shown that pharmacological vitamin C targets many of the mechanisms that cancer cells utilize for their survival and growth. In this Opinion article, we discuss how vitamin C can target … Show more

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Cited by 296 publications
(337 citation statements)
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References 139 publications
(126 reference statements)
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“…In some cases, there have been no benefits. However, new knowledge regarding the pharmacokinetic properties of Vit-C, and recent preclinical studies, have revived interest in the utilization of high-dose Vit-C for cancer treatment [132][133][134][135][136][137][138][139][140][141][142][143][144][145]. Similar is the case of using IV Vit-C as antiviral, especially for the recent Covid19 [146][147][148][149][150].…”
Section: Discussionmentioning
confidence: 99%
“…In some cases, there have been no benefits. However, new knowledge regarding the pharmacokinetic properties of Vit-C, and recent preclinical studies, have revived interest in the utilization of high-dose Vit-C for cancer treatment [132][133][134][135][136][137][138][139][140][141][142][143][144][145]. Similar is the case of using IV Vit-C as antiviral, especially for the recent Covid19 [146][147][148][149][150].…”
Section: Discussionmentioning
confidence: 99%
“…Potential survival benefits of IVC were reported in combination with chemotherapy or radio-chemotherapy in the treatment of pancreatic cancer, glioblastoma multiforme and advanced-stage non-small cell lung cancer (25,28). Several randomized Phase II trials evaluating the efficacy of IVC are underway (48).…”
Section: Discussionmentioning
confidence: 99%
“…We also assume that the ascorbate could serve as a "buffer" of excess-reducing equivalents in the intracellular aqueous phase of cancer cells due to their oxidative environment, because ascorbate is one of the most abundant cytosolic redox-active compounds. Steady-state levels of ascorbate are maintained by Cyb5R3 [6][7][8], and they are significantly higher in cancer cells compared to normal cells [1,36]. Figures 1 and 2 represent two modes of action of vitamin C on mitochondrial homeostasis via generation of AFR and its elimination by the OMM Cyb5R3/VDAC1: (i) "protective mode" at low/normal (steady-state) doses and (ii) "destructive mode" at high doses of vitamin C.…”
Section: Afr In Mitochondrial Homeostasis At Low and High Doses Of VImentioning
confidence: 99%
“…In the April 2019 issue of Nature Reviews Cancer, Ngo et al have described cancer vulnerabilities for high-dose vitamin C therapy [1]. The authors note that vitamin C as a cancer therapy has a controversial history, and much of the controversy arises from the lack of predictive biomarkers for stratification of patients, as well as a clear understanding of the mechanism of action and its multiple targets underlying the anticancer effect [2].…”
Section: Introductionmentioning
confidence: 99%
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