Targeting CDK4/6 in glioblastoma <i>via in situ</i> injection of a cellulose-based hydrogel

Zhang, Xia; Ning, Like; Wu, Hongshuai; Wang, Wenhong; Yang, Suisui; Hu, Ziyi; Cao, Yukun; Xin, Hongliang; You, Chaoqun; Lin, Fan

doi:10.1039/d3nr00378g

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…[6][7][8] With persistent efforts made in the past few years, several viable strategies, including tumor resection, radiotherapy, chemotherapy with temozolomide (TMZ), and immunotherapy, have been developed. [9][10][11] Despite some success, therapy efficacy is still challenging, and the associated adverse effects seriously impact the quality of patients' life. 12,13 Fortunately, TTFields provide a noninvasive method to cure GBMs through affixing transducer arrays on the scalp, which deliver a local low-intensity alternating current electric field (100-400 kHz) locoregionally around the anatomic region of the tumor and selectively disrupt cell division.…”

Section: Introductionmentioning

confidence: 99%

“…6–8 With persistent efforts made in the past few years, several viable strategies, including tumor resection, radiotherapy, chemotherapy with temozolomide (TMZ), and immunotherapy, have been developed. 9–11 Despite some success, therapy efficacy is still challenging, and the associated adverse effects seriously impact the quality of patients' life. 12,13…”

Section: Introductionmentioning

confidence: 99%

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Investigation of sponge medium for efficient concurrent tumor treating fields and radiotherapy for glioblastomas

Zheng,

Zhu,

Guo

et al. 2023

Nanoscale

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation of sponge medium for efficient concurrent tumor treating fields and radiotherapy for glioblastomas

Zheng,

Zhu,

Guo

et al. 2023

Nanoscale

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Biodegradable Cascade‐Amplified Nanotheranostics for Photoacoustic‐Guided Synergistic PTT/CDT/Starvation Antitumor in the NIR‐II Window

Kang,

Wang,

Xin

et al. 2024

Adv Healthcare Materials

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The development of nanoassemblies, activated by the tumor microenvironment, capable of generating photothermal therapy (PTT) and amplifying the “ROS (·OH) storm,” is essential for precise and effective synergistic tumor treatment. Herein, an innovative cascade‐amplified nanotheranostics based on biodegradable Pd‐BSA‐GOx nanocomposite for NIR‐II photoacoustic imaging (PAI) guides self‐enhanced NIR‐II PTT/chemodynamic therapy (CDT)/starvation synergistic therapy. The Pd‐BSA‐GOx demonstrates the ability to selectively convert overexpressed H2O2 into strongly toxic ·OH by a Pd/Pd2+‐mediated Fenton‐like reaction at a lower pH level. Simultaneously, the GOx generates H2O2 and gluconic acid, effectively disrupting nutrient supply and instigating tumor starvation therapy. More importantly, the heightened levels of H2O2 and increased acidity greatly enhance the Fenton‐like reactivity, generating a significant “·OH storm,” thereby achieving Pd2+‐mediated cascade‐amplifying CDT. The specific PTT facilitated by undegraded Pd accelerates the Fenton‐like reaction, establishing a positive feedback process for self‐enhancing synergetic PTT/CDT/starvation therapy via the NIR‐II guided‐PAI. Therefore, the multifunctional nanotheranostics presents a simple and versatile strategy for the precision diagnosis and treatment of tumors.

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Postoperative Injection of a Triptolide‐Preloaded Hydrogel Prevents the Recurrence of Glioblastoma by Dual‐Pathway Activation of Ferroptosis

Wu,

Cao,

Wang

et al. 2024

Small

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Glioblastoma (GBM) recurrence leads to high mortality, which remains a major concern in clinical therapy. Herein, an injectable triptolide (TP)‐preloaded hydrogel (TP@DNH) accompanied by a postoperative injection strategy is developed to prevent the recurrence of GBM. With a potential inhibitor of the NRF2/SLC7A11/GPX4 axis, it is demonstrated that TP can deactivate glutathione peroxidase 4 (GPX4) from the source of glutathione (GSH) biosynthesis, thereby activating ferroptosis in GBM cells by blocking the neutralization of intracellular lipid peroxide (LPO). Based on acid‐sensitive Fe3+/tannic acid (TA) metal‐phenolic networks (MPNs), the TP@DNH hydrogel can induce the effective generation of reactive oxygen species (ROS) through Fe3+/TA‐mediated Fenton reaction and achieve controllable release of TP in resected GBM cavity. Due to ROS generation and GPX4 deactivation, postoperative injection of TP@DNH can achieve high‐level ferroptosis through dual‐pathway LPO accumulation, remarkably suppressing the growth of recurrent GBM and prolonging the overall survival in orthotopic GBM relapse mouse model. This work provides an alternative paradigm for regulating ferroptosis in the postoperative treatment of GBM.

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Targeting CDK4/6 in glioblastoma via in situ injection of a cellulose-based hydrogel

Abstract: Despite aggressive treatments, including surgery, chemo- and radio-therapy, the prognosis of glioblastoma (GBM) remains poor and tumor recurrence is inevitable. The FDA-approved CDK4/6 inhibitor palbociclib (PB) showed interesting anti-GBM effects,...

Cited by 6 publications

References 28 publications

Investigation of sponge medium for efficient concurrent tumor treating fields and radiotherapy for glioblastomas

Investigation of sponge medium for efficient concurrent tumor treating fields and radiotherapy for glioblastomas

Biodegradable Cascade‐Amplified Nanotheranostics for Photoacoustic‐Guided Synergistic PTT/CDT/Starvation Antitumor in the NIR‐II Window

Postoperative Injection of a Triptolide‐Preloaded Hydrogel Prevents the Recurrence of Glioblastoma by Dual‐Pathway Activation of Ferroptosis

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