Targeting FAPα-expressing tumor-associated mesenchymal stromal cells inhibits triple-negative breast cancer pulmonary metastasis

Li, Xiaobo; Chen, Minfeng; Lu, Weijin; Tang, Jun; Deng, Lijuan; Wen, Qing; Huang, Maohua; Deng, Rong; Ye, Geni; Ye, Wen‐Cai; Zhang, Dongmei

doi:10.1016/j.canlet.2021.01.013

Cited by 17 publications

(15 citation statements)

References 43 publications

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“…Triple negative breast cancer (TNBC) is the most malignant subtype of breast cancer that seriously threatens women’s health and lives, and its associated morbidity and mortality have been increasing in recent years [ 1 , 2 ]. Metastasis is one of the main causes of failure in the treatment of TNBC [ 3 , 4 ]. Substantial studies evidenced that platelets support tumor metastatic progression by inducing epithelial-mesenchymal transition (EMT) of cancer cells and by shielding circulating tumor cells from immune-mediated elimination [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Copper-based metal–organic framework impedes triple-negative breast cancer metastasis via local estrogen deprivation and platelets blockade

Wang

Yin

et al. 2022

J Nanobiotechnol

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Metastasis is one of the main causes of failure in the treatment of triple-negative breast cancer (TNBC). Abnormally estrogen level and activated platelets are the key driving forces for TNBC metastasis. Herein, an “ion/gas” bioactive nanogenerator (termed as IGBN), comprising a copper-based MOF and loaded cisplatin-arginine (Pt-Arg) prodrug is developed for metastasis-promoting tumor microenvironment reprogramming and TNBC therapy. The copper-based MOF not only serves as a drug carrier, but also specifically produces Cu2+ in tumors, which catalytic oxidizing estrogen to reduce estrogen levels in situ. Meanwhile, the rationally designed Pt-Arg prodrug reduced into cisplatin to significantly promote the generation of H2O2 in the tumor, then permitting self-augmented cascade NO gas generation by oxidizing Arg through a H2O2 self-supplied way, thus blocking platelet activation in tumor. We clarified that IGBN inhibited TNBC metastasis through local estrogen deprivation and platelets blockade, affording 88.4% inhibition of pulmonary metastasis in a 4T1 mammary adenocarcinoma model. Notably, the locally copper ion interference, NO gas therapy and cisplatin chemotherapy together resulted in an enhanced therapeutic efficacy in primary tumor ablation without significant toxicity. This “ion/gas” bioactive nanogenerator offers a robust and safe strategy for TNBC therapy. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Copper-based metal–organic framework impedes triple-negative breast cancer metastasis via local estrogen deprivation and platelets blockade

Wang

Yin

et al. 2022

J Nanobiotechnol

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“…Direct cellular interaction between mesenchymal stem cells (MSCs) and triple-negative breast cancer (TNBC) cells have been shown to trigger the epithelial-mesenchymal transition (EMT) process in TNBC cells. This transition enhances their invasive and metastatic properties [ 12 , 13 , 14 ]. In addition, MSCs can transmit mitochondria to TNBC cells using either tunneling nanotubes or extracellular vesicles.…”

Section: Effect Of Mscs On Tnbc Cells and Their Tumor Microenvironmen...mentioning

confidence: 99%

“…Therefore, comprehending the mechanisms and ramifications underlying the interplay between MSCs and TNBC assumes paramount importance in devising innovative therapeutic modalities for TNBC [ 13 , 18 ]. By targeting pivotal molecules implicated in this interplay (including, but not limited to, interleukin-6 (IL-6), prostaglandin E2 (PGE2), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and fibroblast activation protein alpha (FAPα) [ 13 ]), novel prospects for surmounting the challenges posed by this formidable breast cancer subtype may emerge.…”

Section: Effect Of Mscs On Tnbc Cells and Their Tumor Microenvironmen...mentioning

confidence: 99%

From Interaction to Intervention: How Mesenchymal Stem Cells Affect and Target Triple-Negative Breast Cancer

Shum

et al. 2023

Biomedicines

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Triple-negative breast cancer (TNBC) lacks estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expressions, making targeted therapies ineffective. Mesenchymal stem cells (MSCs) have emerged as a promising approach for TNBC treatment by modulating the tumor microenvironment (TME) and interacting with cancer cells. This review aims to comprehensively overview the role of MSCs in TNBC treatment, including their mechanisms of action and application strategies. We analyze the interactions between MSC and TNBC cells, including the impact of MSCs on TNBC cell proliferation, migration, invasion, metastasis, angiogenesis, and drug resistance, along with the signaling pathways and molecular mechanisms involved. We also explore the impact of MSCs on other components of the TME, such as immune and stromal cells, and the underlying mechanisms. The review discusses the application strategies of MSCs in TNBC treatment, including their use as cell or drug carriers and the advantages and limitations of different types and sources of MSCs in terms of safety and efficacy. Finally, we discuss the challenges and prospects of MSCs in TNBC treatment and propose potential solutions or improvement methods. Overall, this review provides valuable insights into the potential of MSCs as a novel therapeutic approach for TNBC treatment.

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“…Different sources of CaMSCs all showed immunosuppressive effects, and the targets include macrophages, T-cells, and natural killer (NK) cells. Breast CaMSCs highly expressed FAPα and increased pulmonary metastasis by recruitment of M2 tumor-associated macrophages (TAM), which were identified by F4/80 and CCR2-positive population [ 58 ]. GC-MSC-primed M2 macrophages promoted the migration, invasion, and EMT of gastric cancer cells through secretion of IL-6 and IL-8, and the JAK2/STAT3 signaling pathway [ 59 ].…”

Section: T He Interaction Between Cancer-associated Mesench...mentioning

confidence: 99%

Role of cancer-associated mesenchymal stem cells in the tumor microenvironment: A review

Ding

Wang

2022

Tzu Chi Medical Journal

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A BSTRACT Mesenchymal stem cells (MSCs) were applied to the therapy for degenerative diseases, immune, and inflammation. In tumor microenvironments (TME), different sources of MSCs showed that tumor-promoting and -inhibiting effects were mediated by different signaling pathways. Cancer-associated MSCs (CaMSCs) could be recruited from bone marrow or local tissues and mainly showed tumor-promoting and immunosuppressive effects. The transformed CaMSCs preserve the characteristics of stem cells, but the properties of regulating TME are different. Hence, we specifically focus on CaMSCs and discuss the detailed mechanisms of regulating the development of cancer cells and immune cells. CaMSCs could be a potential therapeutic target in various types of cancer. However, the detailed mechanisms of CaMSCs in the TME are relatively less known and need further study.

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Targeting FAPα-expressing tumor-associated mesenchymal stromal cells inhibits triple-negative breast cancer pulmonary metastasis

Cited by 17 publications

References 43 publications

RETRACTED ARTICLE: Copper-based metal–organic framework impedes triple-negative breast cancer metastasis via local estrogen deprivation and platelets blockade

RETRACTED ARTICLE: Copper-based metal–organic framework impedes triple-negative breast cancer metastasis via local estrogen deprivation and platelets blockade

From Interaction to Intervention: How Mesenchymal Stem Cells Affect and Target Triple-Negative Breast Cancer

Role of cancer-associated mesenchymal stem cells in the tumor microenvironment: A review

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