Targeting Gut Microbiota and Host Metabolism with Dendrobium officinale Dietary Fiber to Prevent Obesity and Improve Glucose Homeostasis in Diet‐Induced Obese Mice

Abstract

Scope: Obesity is becoming a major public health problem due to excess dietary fat intake. Dendrobium officinale (D. officinale) is a medicine food homology plant and exerts multiple health-promoting effects. However, its antiobesity effects and the potential mechanisms remain unclear. Methods and results: High-fat diet (HFD)-fed mice are administered D. officinale dietary fiber (DODF) daily by gavage for 11 weeks. The results show that treatment with DODF alleviates obesity, liver steatosis, inflammation, and oxidant stress in HFD-induced obese mice. Improved glucose homeostasis in obese mice after DODF treatment is achieved by enhancing insulin pathway and hepatic glycogen synthesis. DODF restructures the gut microbiota in obese mice by decreasing the relative abundance of Bilophila and increasing the relative abundances of Akkermansia, Bifidobacterium, and Muribaculum. Also, DODF reshapes the metabolic phenotype of obese mice as indicated by up-regulating energy metabolism, increasing acetate and taurine, and reducing serum low density/very low density lipoproteins (LDL/VLDL). These beneficial effects are partly transferred by FMT, implying the gut microbiota as a target for the protective effect of DODF on obesity-related symptoms. Conclusion: The results suggest that DODF can be used as a novel prebiotics to maintain the gut microbial homeostasis and improve metabolic health, preventing obesity and related metabolic syndrome.

Glutamine Ameliorates Liver Steatosis via Regulation of Glycolipid Metabolism and Gut Microbiota in High-Fat Diet-Induced Obese Mice

“…Previous studies reported that the obese and NAFLD subjects always had a higher abundance of Firmicutes . Gln supplementation decreased the abundance of Firmicutes , Muribaculum , and Lachnospiraceae_NK4A136_group of obese mice as previously described, − while HFD increased the abundance of Lachnospiraceae_UCG-006 . These results demonstrated that Gln supplementation suppresses lipotoxicity induced by the HFD, restoring the healthy microbiota composition.…”

Black bean husk and black rice anthocyanin extracts modulated gut microbiota and serum metabolites for improvement in type 2 diabetic rats

“…is inversely associated with metabolic diseases such as obesity and diabete. 40 Akkermansia spp. supplementation by gavage in obese mice significantly reversed high-fat diet-induced insulin resistance, metabolic endotoxemia, and improved fat accumulation and fasting hyperglycemia.…”

Consumption of sugar sweetened beverages, artificially sweetened beverages and fruit juices and risk of type 2 diabetes, hypertension, cardiovascular disease, and mortality: A meta-analysis

“…Numbers of possible biological mechanisms might explain the positive associations between the consumption of SSBs and ASBs and risk of T2D and cardiometabolic disease. Consumption of SSBs and ASBs is associated with the risk of obesity, which is an independent risk factor for cardiometabolic disease (84,(89)(90)(91)(92). For SSBs, another independent factor may arise from the large amount of rapidly absorbable carbohydrates, such as fructose added to SSBs.…”