Targeting hippocampal phospholipid and tryptophan metabolism for antidepressant-like effects of albiflorin

Wang, Qiang-Song; Yan, Kuo; Li, Kuang-Dai; Gao, Lina; Xu, Wei; Zhang, Zuoguang; Li, Kefeng; Cui, Yuan‐Lu

doi:10.1016/j.phymed.2021.153735

Cited by 26 publications

(15 citation statements)

References 53 publications

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“…Of these, Paeoniflorin possibly plays a neuroprotective effect in improving chronic stress-induced depression and neuronal damage in rats through activation of the ERK-CREB pathway [ 26 , 27 ]. Studies have shown that albiflorin directs antidepressant role by the cytoplasmic phospholipase A2 (cPLA2) -protein kinase B (Akt1)-indoleamine 2,3-dioxidase 1(IDO1) regulatory loop [ 28 ]. Crocin-I has been found to relieve depression-like behaviors may by modulating “microbiota-gut-brain” axis in mice exposed to chronic restraint stress [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Quantitative proteomics reveals the therapeutic effects of RFAP against depression via pathway regulation of long-term depression and potentiation

Hao

Yang

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Quantitative proteomics reveals the therapeutic effects of RFAP against depression via pathway regulation of long-term depression and potentiation

Hao

Yang

et al. 2023

Heliyon

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“…Our results indicated that disturbance of these metabolites may refer to promoting depressive-like phenotypes and olfactory bulb disorder in CMS mice. The abnormal tryptophan metabolism has been reported to associate with MD and depression model (Wang et al, 2021 ; Tian et al, 2022 ). What's more, we first found that linoleic acid metabolism and taurine and hypotaurine metabolism mediated the onset of depression.…”

Section: Discussionmentioning

confidence: 99%

Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis

Chen

Zhou

Chen

et al. 2022

Front. Mol. Neurosci.

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Major depression (MD) is a severe mental illness that creates a heavy social burden, and the potential molecular mechanisms remain largely unknown. Lots of research demonstrate that the olfactory bulb is associated with MD. Recently, gas chromatography-mass spectrometry-based metabolomic studies on depressive rats indicated that metabolisms of purine and lipids were disordered in the olfactory bulb. With various physicochemical properties and extensive concentration ranges, a single analytical technique could not completely cover all metabolites, hence it is necessary to adopt another metabolomic technique to seek new biomarkers or molecular mechanisms for depression. Therefore, we adopted a liquid chromatography-mass spectrometry metabonomic technique in the chronic mild stress (CMS) model to investigate significant metabolic changes in the olfactory bulb of the mice. We discovered and identified 16 differential metabolites in the olfactory bulb of the CMS treatments. Metabolic pathway analysis by MetaboAnalyst 5.0 was generated according to the differential metabolites, which indicated that the tryptophan metabolism pathway was the core pathogenesis in the olfactory bulb of the CMS depression model. Further, the expressions of tryptophan hydroxylase (TpH) and aromatic amino acid decarboxylase (AAAD) were detected by western blotting and immunofluorescence staining. The expression of TpH was increased after CMS treatment, and the level of AAAD was unaltered. These results revealed that abnormal metabolism of the tryptophan pathway in the olfactory bulb mediated the occurrence of MD.

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“…Kynurenin is an important substance in tryptophan metabolism, and a reduction in its content will lead to abnormal tryptophan metabolism. More and more studies have found that tryptophan-kynurenin metabolism plays an important role in depression, which is manifested as the abnormal secretion of tryptophan-kynurenin (70,71). Tryptophan metabolism also closely associated with inflammation, TNF-α and other inflammatory factors, can activate 2,3-dioxygenase oxygen (IDO) and tryptophan enzyme (TDO) through inflammatory signaling pathways, increase tryptophan decomposition and reduce its peripheral content.…”

Section: Discussionmentioning

confidence: 99%

Study of Antidepressant-Like Effects of Albiflorin and Paeoniflorin Through Metabolomics From the Perspective of Cancer-Related Depression

et al. 2022

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Mental health has become a new challenge in cancer treatment, with a high prevalence of depression in patients with cancer. Albiflorin (AF) and paeoniflorinn (PF) are isomers extracted from the root of Paeoniae Radix Alba (Baishao in Chinese), belonging to the monoterpene glycosides, and multiple studies have been conducted on their antidepression and anti-cancer effects. However, the effects of AF and PF on cancer-related depression are unclear. Therefore, the current study aims to investigate whether the two isomers are able to exert antidepressant-like effects and understand the underlying mechanisms in a rat model, established by combining irradiation with chronic restraint stress and solitary confinement. Our results demonstrate a significant regulation of AF and PF in the pharmacodynamic index, including the peripheral blood, organ index, behavioral traits, and HPA axis, relative to control rats. In serum and cerebral cortex metabonomics analysis, AF and PF showed a significantly restorative trend in abnormal biomarkers and regulating ether lipid metabolism, alanine, aspartate, glutamate metabolism, tryptophan metabolism, carnitine metabolism, arachidonic acid metabolism, arginine and proline metabolism pathway. Eight potential biomarkers were further screened by means of receiver operating characteristic (ROC) analysis. The data indicate that AF and PF could effectively ameliorate a depression-like state in the model rats, and the mechanism may be associated with the regulation of the neuroendocrine immune system and disrupted metabolic pathways. Further experiments are warranted to comprehensively evaluate the antidepressant effects of AF and PF in cancer-related depression. This study provides a better insight into the action mechanisms of antidepression of TCM, and provides a new perspective for the therapy of cancer-related depression.

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Targeting hippocampal phospholipid and tryptophan metabolism for antidepressant-like effects of albiflorin

Cited by 26 publications

References 53 publications

Quantitative proteomics reveals the therapeutic effects of RFAP against depression via pathway regulation of long-term depression and potentiation

Quantitative proteomics reveals the therapeutic effects of RFAP against depression via pathway regulation of long-term depression and potentiation

Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis

Study of Antidepressant-Like Effects of Albiflorin and Paeoniflorin Through Metabolomics From the Perspective of Cancer-Related Depression

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