2018
DOI: 10.1002/mc.22827
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Targeting HSP60 by subcutaneous injections of jetPEI/HSP60‐shRNA destabilizes cytoplasmic survivin and inhibits hepatocellular carcinoma growth

Abstract: Heat shock protein 60 (HSP60) overexpresses in various types of cancer, but its expression levels and functions in hepatocellular carcinoma (HCC) are still in dispute. We aim to clarify this issue and examine whether HSP60 could be a therapeutic target for HCC. We found drastically enhanced cell apoptosis and suppressed cell proliferation in two HCC cell lines with HSP60-silencing, and also indicated survivin was involved in this regulatory process in vitro and in vivo. However, HSP60-silencing in normal human… Show more

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Cited by 20 publications
(32 citation statements)
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References 46 publications
(99 reference statements)
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“…In tumor cells, HSP60 and survivin are capable of forming complexes to reside in either the mitochondria or the cytosol for survivin stabilization [9,12]. Consistent with the finding on stabilization of survivin by HSP60, silencing of HSP60 results in a decline of survivin expression [8,9,12].…”
Section: Introductionsupporting
confidence: 74%
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“…In tumor cells, HSP60 and survivin are capable of forming complexes to reside in either the mitochondria or the cytosol for survivin stabilization [9,12]. Consistent with the finding on stabilization of survivin by HSP60, silencing of HSP60 results in a decline of survivin expression [8,9,12].…”
Section: Introductionsupporting
confidence: 74%
“…The role of HSP60 in apoptosis is quite conflicting. To support its anti-apoptotic function, knockdown of HSP60 has been found to promote apoptosis in cardiac myocytes, hepatocellular carcinoma (HCC), and breast cancer cells [11,12,32]. In an inducible cardiac-specific HSP60 knockout mouse model, it has been demonstrated that HSP60 deletion in adult hearts leads to an increased number of apoptotic cardiac myocytes, accompanied by altering mitochondrial complex activity, mitochondrial membrane potential (∆Ψm), and reactive oxidative species production.…”
Section: Hsp60 Functions In Normal and Cancer Cellsmentioning
confidence: 99%
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